HitPredict

Interactor 1: H3 (P02299)
Histone H3
Gene: H3, His3;

Interactor 2: SET1 (Q5LJZ2)
Histone-lysine N-methyltransferase SETD1 (EC 2.1.1.354)
Gene: SET1

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	21694722
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Histone~N-SET, Histone~SET
Common GO terms	GO:0005700 - polytene chromosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 136 Dm			1 1641
+	Hs
		998359 H31_HUMAN (1-136): 3.1e-62: 188: 99.27		EZH2_HUMAN (1099-1624): 5.08e-94: 324: 15.59
+	Hs
		1155419 H31T_HUMAN (1-136): 1.38e-61: 186: 96.32		EZH2_HUMAN (1099-1624): 5.08e-94: 324: 15.59
+	Hs
		998772 H31_HUMAN (1-136): 3.1e-62: 188: 99.27		SETD2_HUMAN (1097-1640): 3.82e-83: 306: 13.71
+	At
		947409 H33_ARATH (1-136): 7.79e-62: 187: 96.32		SUVH4_ARATH (1090-1640): 3.01e-87: 300: 15.01
+	Hs
		998234 H31_HUMAN (1-136): 3.1e-62: 188: 99.27		KMT2A_HUMAN (1127-1641): 2.53e-76: 284: 22.03
+	Hs
		1041540 H31T_HUMAN (1-136): 1.38e-61: 186: 96.32		KMT2A_HUMAN (1127-1641): 2.53e-76: 284: 22.03
+	Hs
		175872 H31_HUMAN (1-136): 3.1e-62: 188: 99.27		SET1A_HUMAN (1199-1641): 1.87e-74: 277: 40.22
+	Hs
		216410 H31_HUMAN (1-136): 3.1e-62: 188: 99.27		SUV91_HUMAN (1288-1640): 8.57e-81: 274: 15.80
+	Hs
		998846 H31_HUMAN (1-136): 3.1e-62: 188: 99.27		ASH1L_HUMAN (1009-1640): 8.03e-72: 269: 13.42
+	Hs
		998807 H31_HUMAN (1-136): 3.1e-62: 188: 99.27		SUV92_HUMAN (1297-1641): 6.25e-77: 263: 15.39
+	Hs
		998942 H31_HUMAN (1-136): 3.1e-62: 188: 99.27		KMT2B_HUMAN (1275-1641): 3.91e-69: 260: 28.65
+	Hs
		355489 H31_HUMAN (1-136): 3.1e-62: 188: 99.27		NSD2_HUMAN (1382-1640): 5.17e-67: 252: 22.43
+	Hs
		355534 H31T_HUMAN (1-136): 1.38e-61: 186: 96.32		NSD2_HUMAN (1382-1640): 5.17e-67: 252: 22.43
+	Hs
		998694 H31_HUMAN (1-136): 3.1e-62: 188: 99.27		NSD1_HUMAN (1398-1640): 6.68e-66: 250: 23.08
+	Hs
		998773 H31_HUMAN (1-136): 3.1e-62: 188: 99.27		NSD3_HUMAN (1398-1640): 9.06e-65: 245: 22.67
+	Hs
		998948 H31_HUMAN (1-136): 3.1e-62: 188: 99.27		SET1B_HUMAN (27-310): 4.57e-62: 237: 25.90
+	Hs
		998821 H31_HUMAN (1-136): 3.1e-62: 188: 99.27		EHMT1_HUMAN (1376-1637): 3.77e-62: 236: 18.49
+	Hs
		161446 H31_HUMAN (1-136): 3.1e-62: 188: 99.27		KMT2D_HUMAN (1405-1641): 5.97e-61: 234: 37.76
+	Hs
		998565 H31_HUMAN (1-136): 3.1e-62: 188: 99.27		KMT2C_HUMAN (1250-1641): 2.15e-57: 223: 27.41
+	Hs
		998840 H31_HUMAN (1-136): 3.1e-62: 188: 99.27		KMT5A_HUMAN (1277-1619): 8.19e-62: 219: 19.37