HitPredict

Interactor 1: CLK2 (P49760)
Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2)
Gene: CLK2

Interactor 2: TR150 (Q9Y2W1)
Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150)
Gene: THRAP3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	28514442, 32707033, 23602568
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016607 - nuclear speck
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 499 Hs			1 955
+	Hs
		833842 CLK1_HUMAN (1-484): 3.66e-144: 424: 53.31		TR150_HUMAN (1-955): 9.81e-127: 408: 100.00
+	Hs
		834151 CLK3_HUMAN (1-499): 1.7e-136: 409: 59.32		TR150_HUMAN (1-955): 9.81e-127: 408: 100.00
+	Hs
		833980 CLK2_HUMAN (1-499): 1.97e-147: 432: 100.00		BCLF1_HUMAN (38-949): 3.55e-78: 276: 33.19
+	Hs
		833824 CLK1_HUMAN (1-484): 3.66e-144: 424: 53.31		BCLF1_HUMAN (38-949): 3.55e-78: 276: 33.19
+	Hs
		833911 CLK2_HUMAN (1-499): 1.97e-147: 432: 100.00		RBBP6_HUMAN (20-841): 1.66e-72: 264: 13.81
+	Hs
		833761 CLK1_HUMAN (1-484): 3.66e-144: 424: 53.31		RBBP6_HUMAN (20-841): 1.66e-72: 264: 13.81
+	Hs
		834136 CLK3_HUMAN (1-499): 1.7e-136: 409: 59.32		BCLF1_HUMAN (38-949): 3.55e-78: 276: 33.19
+	Hs
		834072 CLK3_HUMAN (1-499): 1.7e-136: 409: 59.32		RBBP6_HUMAN (20-841): 1.66e-72: 264: 13.81
+	Hs
		1191723 CLK4_HUMAN (1-484): 6.72e-136: 402: 55.05		RBBP6_HUMAN (20-841): 1.66e-72: 264: 13.81
+	Hs
		625615 CDK2_HUMAN (160-488): 4.25e-133: 389: 24.70		BCLF1_HUMAN (38-949): 3.55e-78: 276: 33.19
+	Hs
		1268600 DYRK2_HUMAN (9-499): 1.04e-115: 355: 22.20		BCLF1_HUMAN (38-949): 3.55e-78: 276: 33.19
+	Hs
		833993 CLK2_HUMAN (1-499): 1.97e-147: 432: 100.00		SRRM2_HUMAN (2-858): 2.43e-23: 109: 14.55
+	Hs
		833836 CLK1_HUMAN (1-484): 3.66e-144: 424: 53.31		SRRM2_HUMAN (2-858): 2.43e-23: 109: 14.55
+	Hs
		834148 CLK3_HUMAN (1-499): 1.7e-136: 409: 59.32		SRRM2_HUMAN (2-858): 2.43e-23: 109: 14.55
+	Hs
		1335031 CLK4_HUMAN (1-484): 6.72e-136: 402: 55.05		SRRM2_HUMAN (2-858): 2.43e-23: 109: 14.55
+	Hs
		69425 CDK2_HUMAN (160-488): 4.25e-133: 389: 24.70		B0AZU3_HUMAN (825-949): 2.88e-31: 121: 62.99
+	Hs
		625642 CDK2_HUMAN (160-488): 4.25e-133: 389: 24.70		SRRM2_HUMAN (2-858): 2.43e-23: 109: 14.55
+	Hs
		1268608 DYRK2_HUMAN (9-499): 1.04e-115: 355: 22.20		SRRM2_HUMAN (2-858): 2.43e-23: 109: 14.55
+	Hs
		625528 CDK2_HUMAN (160-488): 4.25e-133: 389: 24.70		TITIN_HUMAN (105-799): 3.29e-11: 70: 7.20
+	Hs
		1264773 DYRK2_HUMAN (9-499): 1.04e-115: 355: 22.20		TITIN_HUMAN (105-799): 3.29e-11: 70: 7.20