HitPredict

Interactor 1: CLK3 (P49761)
Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3)
Gene: CLK3

Interactor 2: H90B4 (Q58FF6)
Putative heat shock protein HSP 90-beta 4
Gene: HSP90AB4P

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	32707033
Identification Methods	pull down
Interaction Type	association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 638 Hs			1 505
+	Hs
		437997 CLK3_HUMAN (1-638): 0: 542: 100.00		HS90B_HUMAN (1-504): 0: 671: 69.93
+	Hs
		431656 CLK3_HUMAN (1-638): 0: 542: 100.00		HS90A_HUMAN (1-504): 0: 655: 62.96
+	Hs
		437908 CDK2_HUMAN (301-631): 4.28e-138: 406: 24.26		HS90B_HUMAN (1-504): 0: 671: 69.93
+	Hs
		437996 CLK2_HUMAN (149-638): 5.31e-135: 406: 58.52		HS90B_HUMAN (1-504): 0: 671: 69.93
+	Hs
		431549 CDK2_HUMAN (301-631): 4.28e-138: 406: 24.26		HS90A_HUMAN (1-504): 0: 655: 62.96
+	Hs
		431655 CLK2_HUMAN (149-638): 5.31e-135: 406: 58.52		HS90A_HUMAN (1-504): 0: 655: 62.96
+	Hs
		438075 CDK3_HUMAN (301-632): 2.49e-129: 384: 23.89		HS90B_HUMAN (1-504): 0: 671: 69.93
+	Hs
		438155 DYR1A_HUMAN (181-637): 4.69e-123: 384: 26.20		HS90B_HUMAN (1-504): 0: 671: 69.93
+	Hs
		431741 CDK3_HUMAN (301-632): 2.49e-129: 384: 23.89		HS90A_HUMAN (1-504): 0: 655: 62.96
+	Hs
		431834 DYR1A_HUMAN (181-637): 4.69e-123: 384: 26.20		HS90A_HUMAN (1-504): 0: 655: 62.96
+	Hs
		438406 DYRK2_HUMAN (93-633): 2.19e-117: 364: 23.45		HS90B_HUMAN (1-504): 0: 671: 69.93
+	Hs
		438553 DYRK4_HUMAN (199-637): 3.87e-116: 358: 25.74		HS90B_HUMAN (1-504): 0: 671: 69.93
+	Hs
		960099 CDK3_HUMAN (301-632): 2.49e-129: 384: 23.89		H90B4_HUMAN (1-505): 0: 644: 100.00
+	Hs
		432121 DYRK2_HUMAN (93-633): 2.19e-117: 364: 23.45		HS90A_HUMAN (1-504): 0: 655: 62.96
+	Hs
		432288 DYRK4_HUMAN (199-637): 3.87e-116: 358: 25.74		HS90A_HUMAN (1-504): 0: 655: 62.96
+	Hs
		414683 CDK1_HUMAN (301-624): 5.68e-119: 357: 24.70		HS90A_HUMAN (1-504): 0: 655: 62.96
+	Hs
		538107 CDK2_HUMAN (301-631): 4.28e-138: 406: 24.26		ENPL_HUMAN (1-504): 0: 597: 35.70
+	Hs
		432392 DYR1B_HUMAN (210-633): 7.87e-110: 345: 26.85		HS90A_HUMAN (1-504): 0: 655: 62.96
+	Hs
		834058 CLK3_HUMAN (1-638): 0: 542: 100.00		H90B3_HUMAN (1-504): 3.09e-143: 426: 58.87
+	Sp
		383458 CDK1_SCHPO (301-624): 3.89e-118: 355: 23.05		HSP90_SCHPO (1-504): 0: 598: 48.51