HitPredict

Interactor 1: CLK3 (P49761)
Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3)
Gene: CLK3

Interactor 2: PABP4 (Q13310)
Polyadenylate-binding protein 4 (PABP-4) (Poly(A)-binding protein 4) (Activated-platelet protein 1) (APP-1) (Inducible poly(A)-binding protein) (iPABP)
Gene: PABPC4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	23602568
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 638 Hs			1 644
+	Hs
		516417 CLK3_HUMAN (1-638): 0: 542: 100.00		PABP1_HUMAN (1-644): 0: 542: 74.54
+	Hs
		1031320 DYR1A_HUMAN (181-637): 4.69e-123: 384: 26.20		PABP4_HUMAN (1-644): 0: 585: 100.00
+	Hs
		516362 CDK2_HUMAN (301-631): 4.28e-138: 406: 24.26		PABP1_HUMAN (1-644): 0: 542: 74.54
+	Hs
		516416 CLK2_HUMAN (149-638): 5.31e-135: 406: 58.52		PABP1_HUMAN (1-644): 0: 542: 74.54
+	Hs
		516508 DYR1A_HUMAN (181-637): 4.69e-123: 384: 26.20		PABP1_HUMAN (1-644): 0: 542: 74.54
+	Hs
		834096 CLK3_HUMAN (1-638): 0: 542: 100.00		PABP5_HUMAN (4-93): 1.22e-15: 81: 23.33
+	Hs
		1043793 DYR1A_HUMAN (181-637): 4.69e-123: 384: 26.20		ELAV3_HUMAN (3-272): 2.13e-40: 153: 19.15
+	Hs
		582139 CLK1_HUMAN (149-625): 1.2e-137: 412: 48.67		NUCL_HUMAN (2-89): 1.4e-20: 98.4: 31.82
+	Hs
		833945 CLK2_HUMAN (149-638): 5.31e-135: 406: 58.52		PABP5_HUMAN (4-93): 1.22e-15: 81: 23.33
+	Hs
		582281 DYR1A_HUMAN (181-637): 4.69e-123: 384: 26.20		NUCL_HUMAN (2-89): 1.4e-20: 98.4: 31.82
+	Hs
		414728 CDK1_HUMAN (301-624): 5.68e-119: 357: 24.70		NUCL_HUMAN (2-89): 1.4e-20: 98.4: 31.82