HitPredict

Interactor 1: PRP24 (P49960)
U4/U6 snRNA-associated-splicing factor PRP24 (U4/U6 snRNP protein)
Gene: PRP24

Interactor 2: LSM7 (P53905)
U6 snRNA-associated Sm-like protein LSm7
Gene: LSM7

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.925

Property	Details
Experiments	10900456, 11805826, 11720284, 18971323, 16429126
Identification Methods	two hybrid, tandem affinity purification, affinity chromatography technology
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	LSM~Lsm_interact, LSM~RRM_occluded
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005681 - spliceosomal complex GO:0005688 - U6 snRNP
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 444 Sc			1 115
+	Sc
		837114 PRP24_YEAST (1-444): 2.66e-80: 256: 100.00		LSM3_YEAST (25-110): 2.58e-21: 82.7: 31.03
+	Sc
		376834 PABP_YEAST (2-323): 3.4e-55: 194: 15.39		LSM1_YEAST (3-110): 2.93e-28: 102: 28.57
+	Sc
		376893 PABP_YEAST (2-323): 3.4e-55: 194: 15.39		LSM3_YEAST (25-110): 2.58e-21: 82.7: 31.03
+	Sc
		376799 PABP_YEAST (2-323): 3.4e-55: 194: 15.39		RSMB_YEAST (23-107): 9.03e-19: 78.9: 28.13
+	Hs
		927957 SF3B4_HUMAN (22-190): 1.88e-23: 103: 16.58		RSMN_HUMAN (23-103): 1.07e-28: 105: 28.40
+	Hs
		538970 SF3B4_HUMAN (22-190): 1.88e-23: 103: 16.58		RSMB_HUMAN (23-103): 1.03e-27: 103: 28.40
+	Hs
		912047 SF3B4_HUMAN (22-190): 1.88e-23: 103: 16.58		RUXG_HUMAN (24-107): 3.5e-23: 86.9: 33.33
+	Hs
		68422 SF3B4_HUMAN (22-190): 1.88e-23: 103: 16.58		RUXGL_HUMAN (24-107): 5.73e-21: 81.1: 32.14
+	Mm
		646096 TIA1_MOUSE (3-119): 5.5e-11: 65.9: 11.19		RSMB_MOUSE (23-103): 8.52e-28: 103: 28.40