HitPredict

Interactor 1: PRP24 (P49960)
U4/U6 snRNA-associated-splicing factor PRP24 (U4/U6 snRNP protein)
Gene: PRP24

Interactor 2: LSM3 (P57743)
U6 snRNA-associated Sm-like protein LSm3 (SmX4 protein)
Gene: LSM3

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	1.00	0.956

Property	Details
Experiments	10747033, 11720284, 18971323, 16554755, 19740761, 14759368, 16429126
Identification Methods	biochemical, affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	LSM~Lsm_interact, LSM~RRM_occluded
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005681 - spliceosomal complex GO:0005688 - U6 snRNP
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 444 Sc			1 89
+	Sc
		837113 PRP24_YEAST (1-444): 2.66e-80: 256: 100.00		LSM7_YEAST (2-83): 1.07e-20: 80.6: 30.23
+	Sc
		768234 PRP24_YEAST (1-444): 2.66e-80: 256: 100.00		LSM5_YEAST (4-83): 2.79e-19: 76.4: 24.69
+	Sc
		376893 PABP_YEAST (2-323): 3.4e-55: 194: 15.39		LSM3_YEAST (1-89): 1.27e-28: 99.9: 100.00
+	Sc
		376834 PABP_YEAST (2-323): 3.4e-55: 194: 15.39		LSM1_YEAST (8-84): 1.39e-21: 84.5: 29.87
+	Hs
		927957 SF3B4_HUMAN (22-190): 1.88e-23: 103: 16.58		RSMN_HUMAN (10-86): 1.36e-24: 93.7: 26.51
+	Hs
		538970 SF3B4_HUMAN (22-190): 1.88e-23: 103: 16.58		RSMB_HUMAN (10-86): 3.53e-24: 92.9: 26.51
+	Hs
		912465 SF3B4_HUMAN (22-190): 1.88e-23: 103: 16.58		SMD2_HUMAN (4-76): 1.47e-20: 80.2: 28.05
+	Hs
		912047 SF3B4_HUMAN (22-190): 1.88e-23: 103: 16.58		RUXG_HUMAN (8-81): 2.24e-20: 78.7: 27.03
+	Mm
		646096 TIA1_MOUSE (3-119): 5.5e-11: 65.9: 11.19		RSMB_MOUSE (10-86): 4.53e-24: 92.2: 26.51