HitPredict

Interactor 1: CDK9 (P50750)
Cyclin-dependent kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (C-2K) (Cell division cycle 2-like protein kinase 4) (Cell division protein kinase 9) (Serine/threonine-protein kinase PITALRE) (Tat-associated kinase complex catalytic subunit)
Gene: CDK9

Interactor 2: LRRK2 (Q5S007)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)
Gene: LRRK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	unassigned1853
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	Pkinase~Pkinase
Common GO terms	GO:0004672 - protein kinase activity GO:0004674 - protein serine/threonine kinase activity GO:0005524 - ATP binding GO:0006468 - protein phosphorylation GO:0016301 - kinase activity and 1 others more... GO:0106310 - protein serine kinase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 372 Hs			1 2527
+	Hs
		625486 CDK2_HUMAN (16-321): 4.46e-136: 391: 38.76		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		1130666 CDK12_HUMAN (16-371): 1.16e-123: 390: 42.54		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		1092737 Q1HBJ4_HUMAN (5-359): 1.35e-131: 382: 30.99		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		112059 L7RXH5_HUMAN (1-359): 1.92e-131: 382: 30.36		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		647605 MK03_HUMAN (1-359): 1.92e-131: 382: 30.36		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		658967 MK01_HUMAN (5-359): 1.35e-131: 382: 30.99		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		102450 G3V5T9_HUMAN (16-321): 6.88e-131: 380: 33.80		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		414802 CDK1_HUMAN (16-315): 5.07e-124: 361: 40.40		CSK_HUMAN (1722-2140): 2.25e-102: 339: 20.74
+	At
		97545 MPK4_ARATH (7-362): 1.97e-137: 397: 29.41		PBL23_ARATH (1879-2133): 1.46e-85: 288: 27.82
+	At
		97544 MPK3_ARATH (8-353): 3.04e-133: 387: 28.82		PBL23_ARATH (1879-2133): 1.46e-85: 288: 27.82
+	At
		97546 MPK6_ARATH (7-360): 8.07e-133: 386: 29.30		PBL23_ARATH (1879-2133): 1.46e-85: 288: 27.82
+	At
		1105955 MPK1_ARATH (3-368): 1.74e-131: 382: 31.42		PBL17_ARATH (1869-2199): 9.7e-86: 290: 27.08
+	At
		97543 MPK2_ARATH (3-363): 6.43e-132: 384: 31.03		PBL23_ARATH (1879-2133): 1.46e-85: 288: 27.82
+	At
		97548 MPK16_ARATH (17-370): 1.71e-129: 384: 30.06		PBL23_ARATH (1879-2133): 1.46e-85: 288: 27.82
+	At
		97547 MPK7_ARATH (3-363): 8.55e-132: 383: 29.64		PBL23_ARATH (1879-2133): 1.46e-85: 288: 27.82
+	At
		97542 MPK1_ARATH (3-368): 1.74e-131: 382: 31.42		PBL23_ARATH (1879-2133): 1.46e-85: 288: 27.82
+	Hs
		414943 CDK1_HUMAN (16-315): 5.07e-124: 361: 40.40		LRRK1_HUMAN (771-1194): 2.3e-35: 151: 16.38
+	Hs
		658898 MK01_HUMAN (5-359): 1.35e-131: 382: 30.99		M3K10_HUMAN (1864-2136): 2.39e-23: 110: 32.20
+	At
		96046 MPK7_ARATH (3-363): 8.55e-132: 383: 29.64		F4IAN2_ARATH (1885-2136): 5.76e-23: 109: 29.06
+	Os
		1168157 MPK3_ORYSJ (3-360): 1.51e-132: 385: 29.61		Q84PB0_ORYSJ (1857-2136): 4.21e-23: 105: 29.43