HitPredict

Interactor 1: NEK4 (P51957)
Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2)
Gene: NEK4

Interactor 2: NRG1 (Q02297)
Pro-neuregulin-1, membrane-bound isoform (Pro-NRG1) [Cleaved into: Neuregulin-1 (Acetylcholine receptor-inducing activity) (ARIA) (Breast cancer cell differentiation factor p45) (Glial growth factor) (Heregulin) (HRG) (Neu differentiation factor) (Sensory and motor neuron-derived factor)]
Gene: NRG1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.80	0.705

Property	Details
Experiments	26186194, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	I-set~Pkinase
Common GO terms	-
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1 841 Hs			1 640
+	Ce
		136783 O17566_CAEEL (2-840): 9.6e-145: 460: 17.92		UNC89_CAEEL (36-141): 8.69e-12: 71.1: 15.09
+	Hs
		1254357 NEK9_HUMAN (6-330): 1.51e-56: 212: 36.78		TITIN_HUMAN (19-217): 1.22e-10: 67.4: 11.33