HitPredict

Interactor 1: IMA1 (P52292)
Importin subunit alpha-1 (Karyopherin subunit alpha-2) (RAG cohort protein 1) (SRP1-alpha)
Gene: KPNA2

Interactor 2: NUP50 (Q9UKX7)
Nuclear pore complex protein Nup50 (50 kDa nucleoporin) (Nuclear pore-associated protein 60 kDa-like) (Nucleoporin Nup50)
Gene: NUP50

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.974

Property	Details
Experiments	32296183, 12176322, 34079125, 33961781, 25416956, 28514442, 35271311, unassigned1304
Identification Methods	two hybrid, pull down, proximity labelling technology, affinity chromatography technology, two hybrid prey pooling approach, two hybrid array, validated two hybrid, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Arm~NUP50, Arm_3~NUP50
Common GO terms	GO:0005654 - nucleoplasm GO:0006606 - protein import into nucleus GO:0031965 - nuclear membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 529 Hs			1 468
+	Hs
		1192291 Q7Z726_HUMAN (1-529): 1.3e-163: 476: 99.81		NUP50_HUMAN (1-468): 1.01e-131: 390: 100.00
+	Hs
		134978 IMA3_HUMAN (4-529): 5.61e-152: 446: 50.38		NUP50_HUMAN (1-468): 1.01e-131: 390: 100.00
+	Hs
		131527 IMA4_HUMAN (4-529): 6.93e-148: 436: 49.06		NUP50_HUMAN (1-468): 1.01e-131: 390: 100.00
+	Hs
		238747 IMA7_HUMAN (1-528): 1.97e-141: 420: 45.37		NUP50_HUMAN (1-468): 1.01e-131: 390: 100.00
+	Hs
		152769 IMA1_HUMAN (1-529): 6.78e-164: 477: 100.00		RGPD8_HUMAN (196-468): 2.51e-39: 154: 14.34
+	Hs
		853440 IMA1_HUMAN (1-529): 6.78e-164: 477: 100.00		RGPD5_HUMAN (196-468): 4.34e-39: 153: 14.34
+	Hs
		834693 IMA1_HUMAN (1-529): 6.78e-164: 477: 100.00		RBP2_HUMAN (212-468): 1.6e-36: 146: 17.60
+	At
		1280910 IMPA1_ARATH (1-529): 3.69e-156: 457: 45.00		NU50A_ARATH (3-468): 5.16e-44: 161: 17.60
+	At
		138100 IMPA3_ARATH (1-529): 4.06e-156: 457: 43.95		NU50A_ARATH (3-468): 5.16e-44: 161: 17.60
+	At
		97810 IMPA2_ARATH (1-529): 1.12e-155: 456: 44.47		NU50A_ARATH (3-468): 5.16e-44: 161: 17.60
+	At
		285384 IMPA4_ARATH (1-529): 9.28e-155: 454: 43.57		NU50A_ARATH (3-468): 5.16e-44: 161: 17.60
+	At
		1320502 IMPA6_ARATH (1-529): 1.15e-152: 448: 42.46		NU50A_ARATH (3-468): 5.16e-44: 161: 17.60
+	Hs
		134921 IMA3_HUMAN (4-529): 5.61e-152: 446: 50.38		RGPD4_HUMAN (180-468): 1.25e-39: 154: 16.84
+	Hs
		63862 IMA3_HUMAN (4-529): 5.61e-152: 446: 50.38		RGPD3_HUMAN (196-468): 4.76e-39: 153: 14.69
+	Hs
		134843 IMA3_HUMAN (4-529): 5.61e-152: 446: 50.38		RANG_HUMAN (316-466): 8.74e-42: 149: 19.38
+	Hs
		134854 IMA3_HUMAN (4-529): 5.61e-152: 446: 50.38		RBP2_HUMAN (212-468): 1.6e-36: 146: 17.60
+	Hs
		131396 IMA4_HUMAN (4-529): 6.93e-148: 436: 49.06		RANG_HUMAN (316-466): 8.74e-42: 149: 19.38
+	Hs
		131404 IMA4_HUMAN (4-529): 6.93e-148: 436: 49.06		RBP2_HUMAN (212-468): 1.6e-36: 146: 17.60
+	Sc
		691660 IMA1_YEAST (2-529): 3.96e-141: 419: 43.83		NUP2_YEAST (46-466): 3.73e-38: 149: 15.51
+	Sp
		293264 IMA2_SCHPO (11-529): 2.95e-140: 417: 46.52		NUP61_SCHPO (97-468): 1.32e-31: 129: 16.80