HitPredict

Interactor 1: ATRX (P46100)
Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX)
Gene: ATRX

Interactor 2: H4 (P62805)
Histone H4
Gene: H4C1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.915

Property	Details
Experiments	28514442, 30804502, 33961781, 34349018, 23329831
Identification Methods	affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	CENP-T_C~SNF2-rel_dom
Common GO terms	GO:0000781 - chromosome, telomeric region GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006325 - chromatin organization GO:0006334 - nucleosome assembly
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 2492 Hs			1 103
+	Hs
		980403 HELLS_HUMAN (1364-2245): 3.95e-148: 486: 19.32		H4_HUMAN (1-103): 1.39e-48: 151: 100.00
+	Sc
		382175 IRC5_YEAST (1372-2300): 9.12e-147: 482: 20.11		H4_YEAST (18-103): 6.16e-41: 132: 90.70
+	Hs
		903303 SMCA4_HUMAN (1139-2410): 2.82e-133: 463: 12.96		H4_HUMAN (1-103): 1.39e-48: 151: 100.00
+	Hs
		979649 HLTF_HUMAN (1358-2210): 2.28e-130: 439: 15.89		H4_HUMAN (1-103): 1.39e-48: 151: 100.00
+	Sc
		381933 RAD16_YEAST (1396-2209): 8.75e-136: 448: 17.45		H4_YEAST (18-103): 6.16e-41: 132: 90.70
+	Sp
		206383 FFT3_SCHPO (1559-2203): 2.29e-130: 437: 21.24		H4_SCHPO (18-103): 4.89e-42: 135: 89.54
+	Sc
		381934 FUN30_YEAST (1011-2227): 2.83e-124: 425: 17.92		H4_YEAST (18-103): 6.16e-41: 132: 90.70
+	Hs
		980464 CHD7_HUMAN (1927-2476): 1.65e-71: 270: 15.52		H4_HUMAN (1-103): 1.39e-48: 151: 100.00
+	Hs
		979867 SRCAP_HUMAN (2007-2388): 1.27e-69: 264: 22.54		H4_HUMAN (1-103): 1.39e-48: 151: 100.00
+	Hs
		243587 SMCA5_HUMAN (2009-2294): 8.48e-71: 262: 28.28		H4_HUMAN (1-103): 1.39e-48: 151: 100.00
+	Hs
		979570 CHD3_HUMAN (1886-2376): 1.2e-68: 260: 20.60		H4_HUMAN (1-103): 1.39e-48: 151: 100.00
+	Sc
		381871 SNF2_YEAST (2008-2308): 2.84e-69: 262: 27.87		H4_YEAST (18-103): 6.16e-41: 132: 90.70
+	Hs
		980527 INO80_HUMAN (1917-2232): 9.63e-63: 240: 22.84		H4_HUMAN (1-103): 1.39e-48: 151: 100.00
+	Hs
		979665 CHD4_HUMAN (1888-2462): 8.42e-62: 237: 18.62		H4_HUMAN (1-103): 1.39e-48: 151: 100.00
+	Hs
		979535 ERCC6_HUMAN (1559-1852): 9.86e-18: 92.8: 27.45		H4_HUMAN (1-103): 1.39e-48: 151: 100.00
+	Dm
		1014774 ISWI_DROME (1587-1887): 4.54e-13: 77.4: 28.34		H4_DROME (1-103): 4.53e-48: 150: 99.03
+	Sc
		382398 ISW2_YEAST (1559-1890): 1.08e-13: 79.3: 28.31		H4_YEAST (18-103): 6.16e-41: 132: 90.70