HitPredict

Interactor 1: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Interactor 2: KCD17 (Q8N5Z5)
BTB/POZ domain-containing protein KCTD17
Gene: KCTD17

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.55	0.60	0.576

Property	Details
Experiments	25814554, unassigned1126
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 304 Hs			1 314
+	Hs
		642696 CRK_HUMAN (1-304): 1.27e-69: 220: 100.00		KCNA3_HUMAN (7-281): 7.86e-75: 241: 15.30
+	Hs
		642697 CRKL_HUMAN (2-302): 4.59e-59: 193: 47.42		KCNA3_HUMAN (7-281): 7.86e-75: 241: 15.30
+	Hs
		599299 PLCG2_HUMAN (1-301): 3.43e-28: 116: 15.82		KCD17_HUMAN (1-314): 5.34e-102: 303: 100.00
+	Hs
		855705 CRK_HUMAN (1-304): 1.27e-69: 220: 100.00		BACD1_HUMAN (4-178): 1.64e-45: 158: 28.98
+	Hs
		222146 NCK2_HUMAN (2-86): 2.66e-11: 65.6: 19.77		KCD17_HUMAN (1-314): 5.34e-102: 303: 100.00
+	Hs
		987832 GRB2_HUMAN (135-297): 1.31e-26: 106: 17.05		KCNB2_HUMAN (3-260): 2.14e-75: 249: 17.91
+	Hs
		222018 NCK2_HUMAN (2-86): 2.66e-11: 65.6: 19.77		KCNA3_HUMAN (7-281): 7.86e-75: 241: 15.30
+	Hs
		593909 NCK1_HUMAN (2-86): 7.33e-11: 64.1: 19.77		KCNA3_HUMAN (7-281): 7.86e-75: 241: 15.30
+	Hs
		987622 GRB2_HUMAN (135-297): 1.31e-26: 106: 17.05		BACD2_HUMAN (6-203): 1.62e-46: 161: 26.13
+	Mm
		1221234 GRB2_MOUSE (135-297): 8.29e-27: 106: 17.51		BACD1_MOUSE (1-178): 2.1e-45: 158: 26.53
+	Hs
		987789 GRB2_HUMAN (135-297): 1.31e-26: 106: 17.05		SHKB1_HUMAN (14-122): 4.01e-38: 145: 44.95
+	Hs
		1432564 ITSN2_HUMAN (189-304): 5.28e-14: 74.5: 11.86		BACD3_HUMAN (3-203): 2.97e-48: 165: 27.23
+	Mm
		73928 B2RR82_MOUSE (202-299): 7.54e-14: 74.1: 12.00		BACD1_MOUSE (1-178): 2.1e-45: 158: 26.53
+	Mm
		1296473 ITSN1_MOUSE (9-229): 3.95e-13: 71.8: 13.97		BACD1_MOUSE (1-178): 2.1e-45: 158: 26.53
+	Hs
		1384264 SH3K1_HUMAN (114-193): 1.81e-10: 63.7: 21.95		BACD3_HUMAN (3-203): 2.97e-48: 165: 27.23
+	Mm
		237078 NCK2_MOUSE (59-195): 3.43e-11: 65.3: 20.55		BACD1_MOUSE (1-178): 2.1e-45: 158: 26.53
+	Mm
		1296146 SH3K1_MOUSE (114-193): 8.43e-11: 64.4: 20.73		BACD1_MOUSE (1-178): 2.1e-45: 158: 26.53
+	Hs
		222155 NCK2_HUMAN (2-86): 2.66e-11: 65.6: 19.77		SHKB1_HUMAN (14-122): 4.01e-38: 145: 44.95
+	Hs
		1348675 SH3K1_HUMAN (114-193): 1.81e-10: 63.7: 21.95		SHKB1_HUMAN (14-122): 4.01e-38: 145: 44.95
+	Hs
		1384317 SH3K1_HUMAN (114-193): 1.81e-10: 63.7: 21.95		KCTD3_HUMAN (13-131): 1.76e-36: 140: 46.22