HitPredict

Interactor 1: CRKL (P46109)
Crk-like protein
Gene: CRKL

Interactor 2: EPHA4 (P54764)
Ephrin type-A receptor 4 (EC 2.7.10.1) (EPH-like kinase 8) (EK8) (hEK8) (Tyrosine-protein kinase TYRO1) (Tyrosine-protein kinase receptor SEK)
Gene: EPHA4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34349018
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~fn3, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0008284 - positive regulation of cell population proliferation GO:0031594 - neuromuscular junction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 303 Hs			1 986
+	Hs
		913632 VAV2_HUMAN (14-180): 4.48e-40: 150: 19.80		EPHA4_HUMAN (1-986): 0: 1280: 100.00
+	Hs
		619015 PLCG1_HUMAN (5-253): 8.29e-28: 115: 16.60		EPHA4_HUMAN (1-986): 0: 1280: 100.00
+	Hs
		710607 CRK_HUMAN (3-302): 1.42e-51: 173: 54.89		EPHA3_HUMAN (26-986): 0: 1171: 63.01
+	Mm
		1225133 CRK_MOUSE (3-302): 9.88e-52: 174: 54.89		Q8BRB1_MOUSE (10-986): 0: 1164: 62.09
+	Hs
		710791 CRK_HUMAN (3-302): 1.42e-51: 173: 54.89		EPHB2_HUMAN (30-983): 0: 1160: 58.47
+	Hs
		710679 CRKL_HUMAN (1-303): 1.48e-70: 222: 100.00		EPHA8_HUMAN (30-981): 0: 1100: 57.11
+	Hs
		618987 PLCG1_HUMAN (5-253): 8.29e-28: 115: 16.60		EPHB2_HUMAN (30-983): 0: 1160: 58.47
+	Hs
		710114 CRKL_HUMAN (1-303): 1.48e-70: 222: 100.00		EPHA2_HUMAN (27-986): 0: 1053: 50.67
+	Hs
		855564 CRK_HUMAN (3-302): 1.42e-51: 173: 54.89		EPHB3_HUMAN (27-984): 0: 1097: 57.22
+	Hs
		439677 CRKL_HUMAN (1-303): 1.48e-70: 222: 100.00		INSR_HUMAN (281-902): 1.94e-144: 467: 24.65
+	Hs
		439676 CRK_HUMAN (3-302): 1.42e-51: 173: 54.89		INSR_HUMAN (281-902): 1.94e-144: 467: 24.65
+	Hs
		465448 CRK_HUMAN (3-302): 1.42e-51: 173: 54.89		IGF1R_HUMAN (394-884): 1.94e-137: 447: 29.47
+	Hs
		618992 PLCG1_HUMAN (5-253): 8.29e-28: 115: 16.60		UFO_HUMAN (268-937): 7.53e-151: 471: 23.50
+	Hs
		439636 PLCG1_HUMAN (5-253): 8.29e-28: 115: 16.60		INSR_HUMAN (281-902): 1.94e-144: 467: 24.65
+	Rn
		531971 PLCG1_RAT (5-253): 6.42e-29: 118: 15.85		INSR_RAT (284-952): 3.51e-142: 460: 23.78
+	Hs
		557166 CRK_HUMAN (3-302): 1.42e-51: 173: 54.89		SRC_HUMAN (601-871): 2.15e-64: 229: 45.42
+	Hs
		440455 VAV2_HUMAN (14-180): 4.48e-40: 150: 19.80		FYN_HUMAN (615-879): 2.52e-66: 234: 44.20
+	Hs
		440354 PLCG1_HUMAN (5-253): 8.29e-28: 115: 16.60		FYN_HUMAN (615-879): 2.52e-66: 234: 44.20
+	Mm
		813526 PLCG2_MOUSE (5-192): 1.89e-26: 111: 18.23		FYN_MOUSE (615-879): 3.07e-66: 234: 44.20
+	Hs
		557075 PLCG1_HUMAN (5-253): 8.29e-28: 115: 16.60		SRC_HUMAN (601-871): 2.15e-64: 229: 45.42