HitPredict

Interactor 1: NEDD4 (P46934)
E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)
Gene: NEDD4

Interactor 2: LAP4A (Q15012)
Lysosomal-associated transmembrane protein 4A (Golgi 4-transmembrane-spanning transporter MTP)
Gene: LAPTM4A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	33836347, 34297722, 22096579
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005794 - Golgi apparatus
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 1319 Hs			1 233
+	Hs
		861669 NEDD4_HUMAN (1-1319): 0: 1940: 100.00		LAP4B_HUMAN (13-233): 3.59e-79: 241: 44.11
+	Hs
		861597 NEDD4_HUMAN (1-1319): 0: 1940: 100.00		LAPM5_HUMAN (18-230): 1.06e-59: 190: 24.81
+	Hs
		861645 NEDD4_HUMAN (1-1319): 0: 1940: 100.00		Q5TBB8_HUMAN (18-230): 1.06e-59: 190: 24.81
+	Hs
		132045 WWP2_HUMAN (461-799): 1.62e-40: 164: 18.79		LAP4A_HUMAN (1-221): 1.32e-96: 283: 100.00
+	Hs
		1110932 WWP1_HUMAN (385-707): 7.2e-57: 216: 17.48		LAPM5_HUMAN (18-230): 1.06e-59: 190: 24.81
+	Dm
		1377170 SUDX_DROME (435-799): 4.68e-29: 128: 13.38		Q95R82_DROME (19-229): 3.65e-82: 253: 28.86
+	Hs
		132018 WWP2_HUMAN (461-799): 1.62e-40: 164: 18.79		LAPM5_HUMAN (18-230): 1.06e-59: 190: 24.81
+	Hs
		1110929 NED4L_HUMAN (424-676): 1.65e-30: 133: 16.55		LAPM5_HUMAN (18-230): 1.06e-59: 190: 24.81
+	Hs
		1110928 ITCH_HUMAN (305-642): 6.68e-25: 114: 14.82		LAPM5_HUMAN (18-230): 1.06e-59: 190: 24.81
+	Hs
		1110935 SMUF2_HUMAN (485-719): 4.19e-24: 111: 18.55		LAPM5_HUMAN (18-230): 1.06e-59: 190: 24.81
+	Mm
		861877 NEDD4_MOUSE (433-678): 5.12e-22: 105: 15.51		LAPM5_MOUSE (18-230): 7.07e-58: 186: 23.37