HitPredict

Interactor 1: SOX2 (P48432)
Transcription factor SOX-2
Gene: SOX2

Interactor 2: CHD4 (Q6PDQ2)
Chromodomain-helicase-DNA-binding protein 4 (CHD-4) (EC 3.6.4.-)
Gene: CHD4

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.594

Property	Details
Experiments	31077711, 24048479
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0140297 - DNA-binding transcription factor binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 319 Mm			1 1915
+	Mm
		1222137 Q60I23_MOUSE (1-319): 5.92e-68: 216: 98.43		CHD4_MOUSE (1-1903): 0: 1664: 100.00
+	Hs
		872336 SOX2_HUMAN (1-319): 9.05e-67: 213: 94.67		CHD4_HUMAN (1-1915): 0: 1662: 97.76
+	Hs
		1132908 CIC_HUMAN (10-274): 2.9e-43: 160: 23.83		CHD4_HUMAN (1-1915): 0: 1662: 97.76
+	Hs
		872266 SOX2_HUMAN (1-319): 9.05e-67: 213: 94.67		CHD3_HUMAN (19-1908): 0: 1582: 67.77
+	Hs
		776061 SOX5_HUMAN (17-129): 1.87e-39: 149: 40.71		CHD3_HUMAN (19-1908): 0: 1582: 67.77
+	Hs
		239972 SOX15_HUMAN (13-177): 1.88e-39: 140: 48.50		CHD5_HUMAN (79-1912): 0: 1558: 70.43
+	Mm
		59403 Q60I23_MOUSE (1-319): 5.92e-68: 216: 98.43		CHD7_MOUSE (4-1734): 0: 804: 21.99
+	Hs
		872830 SOX2_HUMAN (1-319): 9.05e-67: 213: 94.67		CHD7_HUMAN (4-1734): 0: 795: 21.61
+	Hs
		872559 SOX2_HUMAN (1-319): 9.05e-67: 213: 94.67		CHD6_HUMAN (211-1722): 0: 793: 23.71
+	Mm
		1222147 Q60I23_MOUSE (1-319): 5.92e-68: 216: 98.43		SMCA5_MOUSE (596-1580): 0: 770: 27.16
+	Hs
		243573 SOX2_HUMAN (1-319): 9.05e-67: 213: 94.67		SMCA5_HUMAN (596-1580): 0: 766: 26.91
+	Hs
		872764 SOX2_HUMAN (1-319): 9.05e-67: 213: 94.67		CHD8_HUMAN (7-1734): 0: 753: 22.46
+	Hs
		1401422 CIC_HUMAN (10-274): 2.9e-43: 160: 23.83		CHD7_HUMAN (4-1734): 0: 795: 21.61
+	Hs
		776139 SOX5_HUMAN (17-129): 1.87e-39: 149: 40.71		CHD7_HUMAN (4-1734): 0: 795: 21.61
+	Hs
		776104 SOX5_HUMAN (17-129): 1.87e-39: 149: 40.71		CHD6_HUMAN (211-1722): 0: 793: 23.71
+	Hs
		872382 SOX2_HUMAN (1-319): 9.05e-67: 213: 94.67		CHD9_HUMAN (490-1697): 0: 729: 27.56
+	Hs
		873124 SOX9_HUMAN (27-262): 9.99e-39: 144: 27.24		CHD7_HUMAN (4-1734): 0: 795: 21.61
+	Hs
		243707 CIC_HUMAN (10-274): 2.9e-43: 160: 23.83		SMCA5_HUMAN (596-1580): 0: 766: 26.91
+	Hs
		703383 TF7L2_HUMAN (46-269): 1e-35: 137: 19.11		SMCA1_HUMAN (609-1605): 0: 780: 27.77
+	Hs
		1401401 CIC_HUMAN (10-274): 2.9e-43: 160: 23.83		CHD8_HUMAN (7-1734): 0: 753: 22.46