HitPredict

Interactor 1: UBE2N (P61088)
Ubiquitin-conjugating enzyme E2 N (EC 2.3.2.23) (Bendless-like ubiquitin-conjugating enzyme) (E2 ubiquitin-conjugating enzyme N) (Ubc13) (UbcH13) (Ubiquitin carrier protein N) (Ubiquitin-protein ligase N)
Gene: UBE2N

Interactor 2: RN152 (Q8N8N0)
E3 ubiquitin-protein ligase RNF152 (EC 2.3.2.27) (RING finger protein 152) (RING-type E3 ubiquitin transferase RNF152)
Gene: RNF152

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	1.00	0.800

Property	Details
Experiments	25936802, 19690564
Identification Methods	pull down, two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-RING_5
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0016567 - protein ubiquitination GO:0070534 - protein K63-linked ubiquitination GO:1904262 - negative regulation of TORC1 signaling
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 152 Hs			1 203
+	Hs
		849352 UB2D1_HUMAN (4-149): 3.22e-80: 235: 45.21		SH3R1_HUMAN (1-144): 8.77e-33: 126: 20.83
+	Hs
		1204911 UB2D4_HUMAN (4-149): 5.39e-81: 236: 45.89		TRI50_HUMAN (5-157): 1.41e-32: 123: 22.73
+	Hs
		849360 UB2D1_HUMAN (4-149): 3.22e-80: 235: 45.21		TRI50_HUMAN (5-157): 1.41e-32: 123: 22.73
+	Hs
		1318738 UB2D4_HUMAN (4-149): 5.39e-81: 236: 45.89		TRIM2_HUMAN (4-154): 2.03e-29: 116: 18.79
+	Hs
		262201 UB2D4_HUMAN (4-149): 5.39e-81: 236: 45.89		TRIM3_HUMAN (6-152): 5.72e-28: 112: 20.76
+	Hs
		262161 UB2D1_HUMAN (4-149): 3.22e-80: 235: 45.21		TRIM3_HUMAN (6-152): 5.72e-28: 112: 20.76
+	Hs
		537142 UB2D4_HUMAN (4-149): 5.39e-81: 236: 45.89		TRI27_HUMAN (6-156): 4.31e-27: 109: 19.08
+	Hs
		536760 UB2D1_HUMAN (4-149): 3.22e-80: 235: 45.21		TRI27_HUMAN (6-156): 4.31e-27: 109: 19.08
+	Hs
		849434 UB2D1_HUMAN (4-149): 3.22e-80: 235: 45.21		TRI55_HUMAN (1-177): 2.55e-26: 107: 19.39
+	Hs
		1318719 UB2D4_HUMAN (4-149): 5.39e-81: 236: 45.89		TRIM5_HUMAN (7-156): 2.39e-25: 104: 15.58
+	Hs
		849393 UB2D1_HUMAN (4-149): 3.22e-80: 235: 45.21		TRI63_HUMAN (1-157): 1.45e-26: 105: 17.71
+	Hs
		849439 UB2D1_HUMAN (4-149): 3.22e-80: 235: 45.21		TRIM5_HUMAN (7-156): 2.39e-25: 104: 15.58
+	Hs
		849316 UB2D1_HUMAN (4-149): 3.22e-80: 235: 45.21		TRI32_HUMAN (5-158): 6.04e-25: 103: 26.38
+	Hs
		1317493 UB2D4_HUMAN (4-149): 5.39e-81: 236: 45.89		TRI54_HUMAN (1-157): 1.05e-24: 100: 18.18
+	Hs
		584907 UB2D1_HUMAN (4-149): 3.22e-80: 235: 45.21		RO52_HUMAN (8-156): 1.76e-24: 101: 14.67
+	Hs
		849406 UB2D1_HUMAN (4-149): 3.22e-80: 235: 45.21		TRI11_HUMAN (6-156): 2.39e-24: 101: 16.45
+	Hs
		849433 UB2D1_HUMAN (4-149): 3.22e-80: 235: 45.21		TRI54_HUMAN (1-157): 1.05e-24: 100: 18.18
+	Hs
		734819 UB2D4_HUMAN (4-149): 5.39e-81: 236: 45.89		TRI23_HUMAN (9-86): 2.15e-21: 92.9: 30.00
+	Hs
		734563 UB2D1_HUMAN (4-149): 3.22e-80: 235: 45.21		TRI23_HUMAN (9-86): 2.15e-21: 92.9: 30.00
+	At
		715122 UBC8_ARATH (4-149): 2.42e-80: 235: 46.58		KEG_ARATH (12-82): 1.58e-19: 87.9: 33.78