HitPredict

Interactor 1: DYN2 (P50570)
Dynamin-2 (EC 3.6.5.5) (Dynamin 2) (Dynamin II)
Gene: DNM2

Interactor 2: SNX33 (Q8WV41)
Sorting nexin-33 (SH3 and PX domain-containing protein 3)
Gene: SNX33

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.887

Property	Details
Experiments	33961781, 32814053, unassigned3799, 18353773
Identification Methods	affinity chromatography technology, two hybrid array, two hybrid pooling approach, validated two hybrid, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PH~PX
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0006897 - endocytosis
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 870 Hs			1 574
+	Hs
		896948 DYN2_HUMAN (1-870): 0: 1057: 100.00		SNX9_HUMAN (1-571): 1.4e-140: 421: 34.18
+	Hs
		1050702 DYN1_HUMAN (1-846): 0: 1002: 79.04		SNX33_HUMAN (1-574): 1.53e-158: 467: 100.00
+	Hs
		1357703 DYN3_HUMAN (1-870): 0: 994: 78.41		SNX33_HUMAN (1-574): 1.53e-158: 467: 100.00
+	Hs
		896862 DYN2_HUMAN (1-870): 0: 1057: 100.00		SNX18_HUMAN (1-491): 6.4e-119: 367: 45.84
+	Hs
		1050728 DYN1_HUMAN (1-846): 0: 1002: 79.04		SNX9_HUMAN (1-571): 1.4e-140: 421: 34.18
+	Hs
		1462656 DYN3_HUMAN (1-870): 0: 994: 78.41		SNX9_HUMAN (1-571): 1.4e-140: 421: 34.18
+	Hs
		2961 A0A0D9SFE4_HUMAN (1-851): 0: 994: 78.11		SNX9_HUMAN (1-571): 1.4e-140: 421: 34.18
+	Hs
		255399 DYN2_HUMAN (1-870): 0: 1057: 100.00		SNX2_HUMAN (93-574): 5.4e-75: 249: 16.38
+	Ce
		810578 DYN1_CAEEL (3-823): 0: 899: 61.86		LST4_CAEEL (4-572): 3.25e-117: 360: 31.99
+	Hs
		1111995 DYN3_HUMAN (1-870): 0: 994: 78.41		SNX1_HUMAN (85-574): 1.61e-76: 253: 16.79
+	Hs
		255502 DYN3_HUMAN (1-870): 0: 994: 78.41		SNX2_HUMAN (93-574): 5.4e-75: 249: 16.38
+	Hs
		1462657 DYN3_HUMAN (1-870): 0: 994: 78.41		SNX5_HUMAN (210-573): 2.41e-62: 212: 14.01
+	Hs
		1462313 DYN3_HUMAN (1-870): 0: 994: 78.41		SNX6_HUMAN (203-572): 2.94e-57: 199: 13.32
+	Sc
		639027 VPS1_YEAST (7-739): 0: 693: 37.39		MVP1_YEAST (103-558): 5.23e-57: 201: 14.94