HitPredict

Interactor 1: WDR5 (P61964)
WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein)
Gene: WDR5

Interactor 2: WDR53 (Q7Z5U6)
WD repeat-containing protein 53
Gene: WDR53

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	17041588
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	ANAPC4_WD40~WD40
Common GO terms	-
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 334 Hs			1 358
+	Hs
		903418 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		FBXW7_HUMAN (36-356): 3.3e-72: 239: 14.29
+	Hs
		903551 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		NLE1_HUMAN (77-354): 3.73e-54: 186: 13.90
+	Hs
		863397 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		COPA_HUMAN (86-357): 1.08e-49: 180: 14.19
+	Hs
		903077 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		WDR5_HUMAN (130-357): 1.77e-47: 165: 17.39
+	Hs
		903349 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		WDR5B_HUMAN (130-357): 8.63e-45: 158: 16.96
+	Hs
		792949 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		LIS1_HUMAN (230-355): 2.84e-18: 87.1: 16.54
+	Hs
		725410 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		COPB2_HUMAN (2-77): 3.02e-13: 72.9: 22.08
+	Hs
		903471 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		GRWD1_HUMAN (79-273): 1.11e-12: 70.6: 19.81
+	Dm
		1358845 WDS_DROME (3-290): 7.53e-92: 279: 31.21		WDS_DROME (125-357): 4.13e-46: 162: 15.75
+	Hs
		209416 PLRG1_HUMAN (2-333): 5.29e-85: 267: 26.05		WDR5_HUMAN (130-357): 1.77e-47: 165: 17.39
+	Hs
		793026 LIS1_HUMAN (2-289): 1.55e-94: 288: 29.49		KTNB1_HUMAN (181-356): 4.56e-26: 111: 15.56
+	Hs
		1240442 POC1B_HUMAN (5-251): 5.05e-84: 263: 27.89		POC1A_HUMAN (2-121): 2.36e-31: 124: 17.36
+	Hs
		1103007 SMU1_HUMAN (30-331): 7.66e-39: 145: 28.71		FBXW7_HUMAN (36-356): 3.3e-72: 239: 14.29
+	Mm
		925836 LIS1_MOUSE (2-289): 1.02e-94: 288: 29.49		LIS1_MOUSE (230-355): 2.33e-18: 87.5: 16.54
+	Hs
		792935 LIS1_HUMAN (2-289): 1.55e-94: 288: 29.49		LIS1_HUMAN (230-355): 2.84e-18: 87.1: 16.54
+	Sc
		630844 NLE1_YEAST (167-333): 3.95e-41: 152: 23.70		NLE1_YEAST (195-356): 2.85e-31: 125: 16.95
+	Hs
		1202778 WDR5B_HUMAN (3-198): 4.87e-59: 194: 30.10		GRWD1_HUMAN (79-273): 1.11e-12: 70.6: 19.81