HitPredict

Interactor 1: WDR5 (P61964)
WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein)
Gene: WDR5

Interactor 2: WDR5B (Q86VZ2)
WD repeat-containing protein 5B
Gene: WDR5B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	33961781, 17041588
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	WD40~WD40
Common GO terms	GO:0042393 - histone binding GO:0048188 - Set1C/COMPASS complex
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 334 Hs			1 330
+	Hs
		903077 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		WDR5_HUMAN (2-286): 4.02e-95: 287: 29.21
+	Hs
		903418 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		FBXW7_HUMAN (1-319): 1.47e-88: 281: 28.40
+	Dm
		1358845 WDS_DROME (3-290): 7.53e-92: 279: 31.21		WDS_DROME (2-286): 9.88e-95: 286: 29.90
+	Hs
		196984 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		PRP4_HUMAN (125-330): 6.22e-50: 175: 22.43
+	Hs
		209416 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		PLRG1_HUMAN (158-328): 2.42e-40: 149: 28.66
+	Hs
		903551 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		NLE1_HUMAN (193-329): 6.37e-33: 128: 22.38
+	Hs
		792949 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		LIS1_HUMAN (1-113): 3.92e-31: 122: 20.30
+	Hs
		903428 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		SNR40_HUMAN (197-329): 1.9e-28: 114: 27.61
+	Mm
		925836 LIS1_MOUSE (2-289): 1.02e-94: 288: 29.49		LIS1_MOUSE (1-113): 3.47e-31: 123: 20.30
+	Hs
		792935 LIS1_HUMAN (2-289): 1.55e-94: 288: 29.49		LIS1_HUMAN (1-113): 3.92e-31: 122: 20.30
+	Hs
		1309163 TBL1R_HUMAN (82-333): 6.52e-60: 201: 26.28		TBL1Y_HUMAN (62-330): 1.59e-59: 200: 24.40
+	Hs
		245630 TBL1X_HUMAN (6-202): 8.72e-54: 187: 26.32		TBL1Y_HUMAN (62-330): 1.59e-59: 200: 24.40
+	Hs
		209467 PLRG1_HUMAN (2-333): 5.29e-85: 267: 26.05		SNR40_HUMAN (197-329): 1.9e-28: 114: 27.61
+	Dm
		1358859 WDS_DROME (3-290): 7.53e-92: 279: 31.21		FBXW7_DROME (37-210): 4.42e-22: 99: 33.33
+	Hs
		245633 TBL1R_HUMAN (82-333): 6.52e-60: 201: 26.28		TBL1X_HUMAN (120-330): 1.23e-48: 173: 27.56
+	Hs
		1288273 WDR83_HUMAN (25-333): 8.76e-84: 257: 31.83		SNR40_HUMAN (197-329): 1.9e-28: 114: 27.61
+	Hs
		245546 TBL1X_HUMAN (6-202): 8.72e-54: 187: 26.32		TBL1X_HUMAN (120-330): 1.23e-48: 173: 27.56
+	Hs
		1240442 POC1B_HUMAN (5-251): 5.05e-84: 263: 27.89		POC1A_HUMAN (2-71): 6.73e-17: 82.7: 22.86