HitPredict

Interactor 1: PRS8 (P62195)
26S proteasome regulatory subunit 8 (26S proteasome AAA-ATPase subunit RPT6) (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (Thyroid hormone receptor-interacting protein 1) (TRIP1) (p45/SUG)
Gene: PSMC5

Interactor 2: NR1H3 (Q13133)
Oxysterols receptor LXR-alpha (Liver X receptor alpha) (Nuclear receptor subfamily 1 group H member 3)
Gene: NR1H3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	15604093
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 406 Hs			1 447
+	Hs
		587150 PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00		RXRA_HUMAN (6-445): 5.73e-129: 382: 22.89
+	Hs
		369311 PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00		ESR1_HUMAN (6-446): 3.36e-116: 354: 20.04
+	Rn
		411261 PRS8_RAT (1-406): 1.42e-136: 398: 100.00		ESR1_RAT (6-446): 6.04e-114: 348: 20.46
+	Hs
		906980 PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00		ERR3_HUMAN (9-446): 1.89e-114: 345: 23.76
+	Hs
		500362 PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00		RARB_HUMAN (14-447): 3.03e-114: 344: 28.25
+	Hs
		369310 PRS4_HUMAN (4-396): 7.85e-130: 382: 46.31		ESR1_HUMAN (6-446): 3.36e-116: 354: 20.04
+	Hs
		487934 PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00		RARA_HUMAN (15-447): 1.17e-111: 338: 29.00
+	Hs
		509930 PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00		VDR_HUMAN (95-446): 9.2e-109: 329: 32.21
+	Hs
		530791 PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00		RARG_HUMAN (17-447): 8.95e-108: 328: 29.17
+	Hs
		907027 PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00		HNF4G_HUMAN (89-443): 2.22e-106: 322: 24.72
+	Hs
		611412 PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00		NR4A1_HUMAN (4-443): 9.26e-103: 319: 27.25
+	Hs
		740491 PRS4_HUMAN (4-396): 7.85e-130: 382: 46.31		PPARG_HUMAN (69-443): 3.18e-108: 330: 27.64
+	Hs
		907111 PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00		ESR2_HUMAN (2-446): 1.53e-101: 314: 19.69
+	Hs
		510012 PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00		ERR1_HUMAN (29-445): 3.13e-102: 312: 25.46
+	Hs
		611411 PRS4_HUMAN (4-396): 7.85e-130: 382: 46.31		NR4A1_HUMAN (4-443): 9.26e-103: 319: 27.25
+	Hs
		500475 PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00		THB_HUMAN (36-444): 7.14e-98: 302: 28.81
+	Hs
		906889 PRS4_HUMAN (4-396): 7.85e-130: 382: 46.31		ESR2_HUMAN (2-446): 1.53e-101: 314: 19.69
+	Hs
		907028 PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00		NR1I3_HUMAN (98-442): 2.14e-50: 176: 32.58
+	Hs
		265859 PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00		NR1I2_HUMAN (75-445): 8.74e-49: 174: 29.67
+	Hs
		906997 PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00		PPARD_HUMAN (95-443): 7.31e-38: 144: 29.95