HitPredict

Interactor 1: AFF1 (P51825)
AF4/FMR2 family member 1 (ALL1-fused gene from chromosome 4 protein) (Protein AF-4) (Protein FEL) (Proto-oncogene AF4)
Gene: AFF1

Interactor 2: ENL (Q03111)
Protein ENL (YEATS domain-containing protein 1)
Gene: MLLT1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.970

Property	Details
Experiments	25921070, 33961781, 19956800, 20431927, 20153263, 15856011, 21030982, 24367103
Identification Methods	affinity chromatography technology, two hybrid, pull down, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	AF4_int~AHD
Common GO terms	GO:0008023 - transcription elongation factor complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 559
+	Hs
		839869 AFF1_HUMAN (1-1210): 5.21e-124: 414: 100.00		AF9_HUMAN (1-559): 3.63e-75: 250: 52.36
+	Hs
		1040765 AFF4_HUMAN (10-1208): 4.37e-90: 318: 33.78		ENL_HUMAN (1-559): 1.83e-78: 259: 100.00
+	Hs
		839930 AFF4_HUMAN (10-1208): 4.37e-90: 318: 33.78		AF9_HUMAN (1-559): 3.63e-75: 250: 52.36
+	Hs
		908297 AFF3_HUMAN (6-1207): 3.25e-76: 278: 23.71		ENL_HUMAN (1-559): 1.83e-78: 259: 100.00
+	Hs
		839870 AFF3_HUMAN (6-1207): 3.25e-76: 278: 23.71		AF9_HUMAN (1-559): 3.63e-75: 250: 52.36
+	Hs
		839897 NIPBL_HUMAN (12-935): 7.66e-53: 206: 12.72		AF9_HUMAN (1-559): 3.63e-75: 250: 52.36
+	Hs
		1368512 AFF4_HUMAN (10-1208): 4.37e-90: 318: 33.78		CBP_HUMAN (36-507): 1.13e-27: 120: 11.67
+	Hs
		1235637 NIPBL_HUMAN (12-935): 7.66e-53: 206: 12.72		NIPBL_HUMAN (118-550): 3.3e-33: 137: 15.40
+	Hs
		590279 MUC1_HUMAN (48-1024): 2.81e-44: 177: 9.21		EP300_HUMAN (36-507): 8.6e-31: 130: 10.54
+	Hs
		1067841 BSN_HUMAN (4-1116): 8.02e-31: 134: 9.08		EP300_HUMAN (36-507): 8.6e-31: 130: 10.54
+	Mm
		74238 F8VPR5_MOUSE (72-770): 7.58e-29: 128: 12.22		EP300_MOUSE (36-507): 2.48e-26: 116: 10.00
+	Hs
		1454808 RERE_HUMAN (24-836): 6.92e-11: 69.3: 8.88		YETS2_HUMAN (3-502): 5.26e-36: 146: 12.96
+	Hs
		1067330 MDC1_HUMAN (84-869): 9.51e-12: 72: 15.09		EP300_HUMAN (36-507): 8.6e-31: 130: 10.54
+	Hs
		161457 KMT2D_HUMAN (23-1021): 4.87e-11: 69.7: 10.24		EP300_HUMAN (36-507): 8.6e-31: 130: 10.54
+	Hs
		1067788 RERE_HUMAN (24-836): 6.92e-11: 69.3: 8.88		EP300_HUMAN (36-507): 8.6e-31: 130: 10.54
+	Hs
		1067605 ZN469_HUMAN (26-1024): 3.71e-09: 63.5: 9.59		EP300_HUMAN (36-507): 8.6e-31: 130: 10.54
+	Hs
		1129671 MDC1_HUMAN (84-869): 9.51e-12: 72: 15.09		CBP_HUMAN (36-507): 1.13e-27: 120: 11.67
+	Hs
		161499 KMT2D_HUMAN (23-1021): 4.87e-11: 69.7: 10.24		CBP_HUMAN (36-507): 1.13e-27: 120: 11.67
+	Mm
		1455913 PCLO_MOUSE (6-936): 8.38e-20: 98.6: 10.27		PCLO_MOUSE (85-510): 7.31e-10: 64.4: 10.89
+	Dm
		119660 M9PB30_DROME (494-1136): 1.24e-11: 72: 8.99		M9PB30_DROME (160-482): 3.8e-12: 71.7: 10.35