HitPredict

Interactor 1: ATN1 (P54259)
Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein)
Gene: ATN1

Interactor 2: KMT2A (Q03164)
Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]
Gene: KMT2A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	24981860
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0009791 - post-embryonic development
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1190 Hs			1 3969
+	Hs
		1041559 KMT2C_HUMAN (183-999): 4.38e-17: 89.8: 12.62		KMT2A_HUMAN (1-3969): 0: 3227: 100.00
+	Hs
		903135 SMCA2_HUMAN (208-500): 1.57e-13: 78: 15.15		KMT2A_HUMAN (1-3969): 0: 3227: 100.00
+	Hs
		928364 ATN1_HUMAN (1-1190): 1.01e-149: 482: 100.00		KMT2B_HUMAN (3525-3969): 1.17e-87: 324: 54.51
+	Hs
		216477 Q86V38_HUMAN (1-1190): 1.98e-148: 479: 98.83		SUV91_HUMAN (3602-3968): 3.98e-87: 294: 18.39
+	Hs
		928365 ATN1_HUMAN (1-1190): 1.01e-149: 482: 100.00		SET1B_HUMAN (3529-3969): 8.08e-69: 261: 26.17
+	Hs
		175863 ATN1_HUMAN (1-1190): 1.01e-149: 482: 100.00		SET1A_HUMAN (3695-3969): 7.81e-56: 219: 34.58
+	Hs
		928302 ATN1_HUMAN (1-1190): 1.01e-149: 482: 100.00		KMT2C_HUMAN (1816-1977): 4.38e-11: 72.1: 24.10
+	Hs
		590286 MUC1_HUMAN (293-1133): 5.23e-41: 166: 14.00		EZH2_HUMAN (3450-3951): 2.55e-103: 353: 18.39
+	Hs
		1155689 MUC4_HUMAN (2-1021): 3.63e-17: 89.9: 10.66		EZH2_HUMAN (3450-3951): 2.55e-103: 353: 18.39
+	Hs
		1155553 KMT2C_HUMAN (183-999): 4.38e-17: 89.8: 12.62		EZH2_HUMAN (3450-3951): 2.55e-103: 353: 18.39
+	Hs
		903167 SMCA2_HUMAN (208-500): 1.57e-13: 78: 15.15		EZH2_HUMAN (3450-3951): 2.55e-103: 353: 18.39
+	Hs
		1155846 CHD7_HUMAN (232-913): 8.14e-13: 75.7: 11.81		EZH2_HUMAN (3450-3951): 2.55e-103: 353: 18.39
+	Hs
		1338285 KMT2C_HUMAN (183-999): 4.38e-17: 89.8: 12.62		KMT2B_HUMAN (3525-3969): 1.17e-87: 324: 54.51
+	Dm
		1208012 Q9VLS7_DROME (198-1147): 2.29e-14: 80.7: 12.03		SET1_DROME (3423-3969): 7.78e-82: 303: 22.11
+	Hs
		1129732 MDC1_HUMAN (99-1036): 6.17e-15: 82.6: 10.11		SETD2_HUMAN (3398-3968): 9.76e-78: 291: 15.76
+	Hs
		1338286 KMT2C_HUMAN (183-999): 4.38e-17: 89.8: 12.62		SET1B_HUMAN (3529-3969): 8.08e-69: 261: 26.17
+	Hs
		355522 MDC1_HUMAN (99-1036): 6.17e-15: 82.6: 10.11		NSD2_HUMAN (3752-3968): 6.99e-60: 231: 27.23
+	Hs
		175910 KMT2C_HUMAN (183-999): 4.38e-17: 89.8: 12.62		SET1A_HUMAN (3695-3969): 7.81e-56: 219: 34.58
+	Hs
		903248 SMCA2_HUMAN (208-500): 1.57e-13: 78: 15.15		NSD3_HUMAN (3750-3968): 4.91e-56: 219: 25.68
+	Hs
		161491 KMT2C_HUMAN (183-999): 4.38e-17: 89.8: 12.62		KMT2D_HUMAN (15-1365): 1.92e-09: 66.8: 9.31