HitPredict

Interactor 1: SOX10 (P56693)
Transcription factor SOX-10
Gene: SOX10

Interactor 2: LMO3 (Q8TAP4)
LIM domain only protein 3 (LMO-3) (Neuronal-specific transcription factor DAT1) (Rhombotin-3)
Gene: LMO3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	32814053
Identification Methods	two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0140297 - DNA-binding transcription factor binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 466 Hs			1 145
+	Hs
		1401453 CIC_HUMAN (34-358): 3.14e-43: 165: 19.10		LHX6_HUMAN (3-137): 8.87e-42: 143: 36.30
+	Hs
		872612 SOX2_HUMAN (72-239): 3.75e-38: 143: 38.04		ISL2_HUMAN (11-131): 2.08e-48: 160: 39.34
+	Hs
		681762 SOX5_HUMAN (96-180): 2.84e-37: 147: 47.06		RBTN2_HUMAN (13-133): 8.24e-46: 148: 60.33
+	Hs
		1229356 PB1_HUMAN (1-336): 3.87e-34: 138: 12.21		LHX8_HUMAN (12-132): 3.06e-46: 155: 39.67
+	Hs
		1288012 PB1_HUMAN (1-336): 3.87e-34: 138: 12.21		LHX6_HUMAN (3-137): 8.87e-42: 143: 36.30
+	Ce
		629529 EGL13_CAEEL (17-187): 1.19e-32: 131: 31.98		HM14_CAEEL (3-141): 2.23e-40: 139: 28.37
+	Hs
		682010 SOX5_HUMAN (96-180): 2.84e-37: 147: 47.06		RBTN1_HUMAN (1-133): 4.57e-36: 123: 95.49
+	Hs
		1287955 PB1_HUMAN (1-336): 3.87e-34: 138: 12.21		LMO3_HUMAN (1-145): 2.03e-36: 123: 100.00
+	Hs
		1393030 CIC_HUMAN (34-358): 3.14e-43: 165: 19.10		PDLI5_HUMAN (3-66): 1.23e-12: 65.8: 27.69
+	Hs
		1379935 CIC_HUMAN (34-358): 3.14e-43: 165: 19.10		LHX4_HUMAN (4-83): 1.38e-11: 62.7: 17.28
+	Hs
		253024 CIC_HUMAN (34-358): 3.14e-43: 165: 19.10		LMX1B_HUMAN (4-72): 3.9e-11: 61.2: 25.71
+	Hs
		1401424 CIC_HUMAN (34-358): 3.14e-43: 165: 19.10		LHX3_HUMAN (4-74): 9.36e-11: 60: 19.44
+	Hs
		895783 CIC_HUMAN (34-358): 3.14e-43: 165: 19.10		LHX2_HUMAN (5-78): 3.79e-10: 58.5: 22.67
+	Dm
		1174480 DICH_DROME (101-207): 1.68e-40: 151: 48.60		Q9V472_DROME (72-144): 2.07e-11: 62.3: 23.29
+	Hs
		776144 SOX5_HUMAN (96-180): 2.84e-37: 147: 47.06		LHX3_HUMAN (4-74): 9.36e-11: 60: 19.44
+	Hs
		872773 SOX2_HUMAN (72-239): 3.75e-38: 143: 38.04		LHX9_HUMAN (5-75): 5.03e-10: 58.1: 23.61
+	Hs
		1287971 PB1_HUMAN (1-336): 3.87e-34: 138: 12.21		LHX4_HUMAN (4-83): 1.38e-11: 62.7: 17.28
+	Hs
		1288006 PB1_HUMAN (1-336): 3.87e-34: 138: 12.21		LHX3_HUMAN (4-74): 9.36e-11: 60: 19.44
+	Hs
		877528 PB1_HUMAN (1-336): 3.87e-34: 138: 12.21		LHX1_HUMAN (4-78): 9.53e-11: 60: 25.00
+	Hs
		895745 PB1_HUMAN (1-336): 3.87e-34: 138: 12.21		LHX2_HUMAN (5-78): 3.79e-10: 58.5: 22.67