HitPredict

Interactor 1: BCAR1 (P56945)
Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (Cas scaffolding protein family member 1) (p130cas)
Gene: BCAR1

Interactor 2: SH23A (Q9BRG2)
SH2 domain-containing protein 3A (Novel SH2-containing protein 1)
Gene: SH2D3A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.80	0.757

Property	Details
Experiments	10187783, 33961781, 36652389
Identification Methods	affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SH2~SH3_1
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 870 Hs			1 576
+	Hs
		942744 BCAR1_HUMAN (1-870): 1.95e-107: 353: 100.00		SH2D3_HUMAN (9-574): 0: 603: 33.13
+	Hs
		294847 BCAR1_HUMAN (1-870): 1.95e-107: 353: 100.00		BCAR3_HUMAN (8-574): 0: 576: 35.42
+	Hs
		557192 BCAR1_HUMAN (1-870): 1.95e-107: 353: 100.00		SRC_HUMAN (3-256): 3.18e-61: 213: 12.36
+	Hs
		463036 BCAR1_HUMAN (1-870): 1.95e-107: 353: 100.00		YES_HUMAN (3-256): 1.1e-60: 211: 12.36
+	Hs
		440468 BCAR1_HUMAN (1-870): 1.95e-107: 353: 100.00		FYN_HUMAN (3-256): 6.45e-60: 209: 13.76
+	Hs
		463425 BCAR1_HUMAN (1-870): 1.95e-107: 353: 100.00		LYN_HUMAN (3-256): 4.98e-57: 201: 11.61
+	Rn
		1224621 BCAR1_RAT (2-870): 2.57e-102: 341: 89.12		SRC_RAT (3-256): 2.21e-60: 211: 12.73
+	Rn
		1224292 BCAR1_RAT (2-870): 2.57e-102: 341: 89.12		FYN_RAT (3-256): 6.45e-60: 209: 13.76
+	Mm
		813523 BCAR1_MOUSE (1-870): 1.21e-101: 337: 88.67		FYN_MOUSE (3-256): 1.66e-60: 211: 13.76
+	Mm
		431351 BCAR1_MOUSE (1-870): 1.21e-101: 337: 88.67		SRC_MOUSE (3-256): 3.01e-60: 210: 12.73
+	Hs
		473388 BCAR1_HUMAN (1-870): 1.95e-107: 353: 100.00		HCK_HUMAN (3-253): 2.69e-54: 194: 13.64
+	Hs
		440009 BCAR1_HUMAN (1-870): 1.95e-107: 353: 100.00		LCK_HUMAN (3-253): 1.89e-53: 191: 14.39
+	Mm
		683100 BCAR1_MOUSE (1-870): 1.21e-101: 337: 88.67		LYN_MOUSE (3-256): 3.51e-57: 201: 11.99
+	Hs
		362226 BCAR1_HUMAN (1-870): 1.95e-107: 353: 100.00		ABL1_HUMAN (3-223): 5.81e-48: 182: 18.34
+	Hs
		855567 BCAR1_HUMAN (1-870): 1.95e-107: 353: 100.00		CRK_HUMAN (3-246): 1.09e-50: 178: 21.17
+	Hs
		908191 BCAR1_HUMAN (1-870): 1.95e-107: 353: 100.00		BMX_HUMAN (9-255): 5.62e-47: 176: 15.18
+	Hs
		855840 BCAR1_HUMAN (1-870): 1.95e-107: 353: 100.00		CRKL_HUMAN (7-246): 2.17e-47: 169: 16.17
+	Rn
		1224619 BCAR1_RAT (2-870): 2.57e-102: 341: 89.12		CRK_RAT (3-246): 1.77e-50: 178: 21.17
+	Hs
		942540 BCAR1_HUMAN (1-870): 1.95e-107: 353: 100.00		GRB2_HUMAN (3-166): 1.35e-44: 159: 19.21
+	Mm
		868838 BCAR1_MOUSE (1-870): 1.21e-101: 337: 88.67		CRKL_MOUSE (7-246): 7.02e-47: 168: 15.41