HitPredict

Interactor 1: CRKL (P47941)
Crk-like protein
Gene: CRKL

Interactor 2: BCAR1 (Q61140)
Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas)
Gene: BCAR1

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	8978305
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~SH3_1, SH3_1~SH3_1, SH3_1~SH3_2
Common GO terms	GO:0005829 - cytosol GO:0060326 - cell chemotaxis GO:0086100 - endothelin receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 303 Mm			1 874
+	Hs
		855840 CRKL_HUMAN (1-303): 2.96e-76: 236: 96.70		BCAR1_HUMAN (1-874): 2.43e-125: 400: 90.16
+	Hs
		855872 CRKL_HUMAN (1-303): 2.96e-76: 236: 96.70		CASL_HUMAN (1-872): 1.54e-117: 379: 35.34
+	Mm
		1222334 CRK_MOUSE (3-302): 1.25e-59: 194: 54.57		BCAR1_MOUSE (1-874): 8e-129: 410: 100.00
+	Rn
		1224619 CRK_RAT (3-302): 1.29e-59: 194: 54.26		BCAR1_RAT (4-874): 2.91e-127: 408: 96.90
+	Hs
		855567 CRK_HUMAN (3-302): 1.53e-59: 194: 54.57		BCAR1_HUMAN (1-874): 2.43e-125: 400: 90.16
+	Mm
		204404 CRK_MOUSE (3-302): 1.25e-59: 194: 54.57		CASL_MOUSE (1-872): 1.83e-119: 384: 36.59
+	Hs
		855624 CRK_HUMAN (3-302): 1.53e-59: 194: 54.57		CASL_HUMAN (1-872): 1.54e-117: 379: 35.34
+	Hs
		942540 GRB2_HUMAN (126-297): 4.6e-30: 115: 15.28		BCAR1_HUMAN (1-874): 2.43e-125: 400: 90.16
+	Hs
		855768 CRK_HUMAN (3-302): 1.53e-59: 194: 54.57		CASS4_HUMAN (4-869): 1.69e-60: 222: 21.96
+	Hs
		855918 CRKL_HUMAN (1-303): 2.96e-76: 236: 96.70		SH3K1_HUMAN (7-368): 2.4e-26: 117: 14.67
+	Hs
		211981 CRK_HUMAN (3-302): 1.53e-59: 194: 54.57		EFS_HUMAN (324-872): 3.59e-34: 140: 24.46
+	Hs
		855715 CRK_HUMAN (3-302): 1.53e-59: 194: 54.57		SH3K1_HUMAN (7-368): 2.4e-26: 117: 14.67
+	Hs
		211976 PLCG1_HUMAN (3-200): 5.53e-28: 115: 20.09		EFS_HUMAN (324-872): 3.59e-34: 140: 24.46
+	Hs
		211984 GRB2_HUMAN (126-297): 4.6e-30: 115: 15.28		EFS_HUMAN (324-872): 3.59e-34: 140: 24.46
+	Hs
		590268 GRB2_HUMAN (126-297): 4.6e-30: 115: 15.28		MUC1_HUMAN (63-576): 1.4e-26: 119: 9.46
+	Mm
		1221245 GRB2_MOUSE (126-297): 3.08e-30: 115: 15.28		SH3K1_MOUSE (7-368): 2.81e-25: 114: 15.49
+	Mm
		1298741 PLCG2_MOUSE (3-192): 7.6e-28: 115: 18.54		SH3K1_MOUSE (7-368): 2.81e-25: 114: 15.49
+	Hs
		176259 GRB2_HUMAN (126-297): 4.6e-30: 115: 15.28		SYNJ2_HUMAN (86-519): 9.95e-25: 113: 14.38
+	Hs
		913671 VAV2_HUMAN (14-180): 5.46e-41: 153: 21.29		TITIN_HUMAN (59-730): 2.11e-09: 64.1: 11.63
+	Hs
		215914 GRB2_HUMAN (126-297): 4.6e-30: 115: 15.28		SYNJ1_HUMAN (127-568): 6.98e-15: 81.4: 11.80