HitPredict

Interactor 1: AP2A (P91926)
AP-2 complex subunit alpha (Alpha-adaptin)
Gene: AP-2alpha

Interactor 2: Q9VDC3 (Q9VDC3)
AP complex subunit sigma
Gene: AP-2sigma

Species: Drosophila melanogaster

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	22036573
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Adaptin_N~Clat_adaptor_s
Common GO terms	GO:0006886 - intracellular protein transport GO:0006897 - endocytosis GO:0030122 - AP-2 adaptor complex GO:0035615 - clathrin adaptor activity GO:0072583 - clathrin-dependent endocytosis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 940 Dm			1 142
+	Dm
		248292 AP2A_DROME (1-940): 0: 839: 100.00		O62530_DROME (1-138): 2.32e-42: 146: 16.67
+	Mm
		567520 AP2A2_MOUSE (1-940): 0: 837: 69.67		AP2S1_MOUSE (1-142): 4.85e-46: 148: 95.78
+	Rn
		577193 AP2A2_RAT (1-940): 0: 835: 69.57		AP2M1_RAT (1-138): 1.51e-41: 144: 15.22
+	Hs
		302125 AP2A2_HUMAN (1-940): 0: 829: 69.18		AP2S1_HUMAN (1-142): 4.85e-46: 148: 95.78
+	Hs
		302192 AP2A2_HUMAN (1-940): 0: 829: 69.18		AP2M1_HUMAN (1-138): 1.51e-41: 144: 15.22
+	Hs
		321516 AP2A1_HUMAN (1-940): 0: 815: 65.48		AP2S1_HUMAN (1-142): 4.85e-46: 148: 95.78
+	Hs
		321614 AP2A1_HUMAN (1-940): 0: 815: 65.48		AP2M1_HUMAN (1-138): 1.51e-41: 144: 15.22
+	Ce
		725364 Q22601_CAEEL (1-940): 0: 773: 65.29		AP2M_CAEEL (1-138): 1.9e-43: 149: 15.94
+	Ce
		1090495 Q22601_CAEEL (1-940): 0: 773: 65.29		Q19123_CAEEL (1-142): 4.23e-45: 145: 94.37
+	At
		1196568 AP2A1_ARATH (6-940): 0: 692: 37.56		AP2S_ARATH (1-142): 1.23e-44: 144: 59.86
+	Hs
		903681 AP2B1_HUMAN (33-935): 0: 669: 16.31		AP1S1_HUMAN (1-142): 1.95e-51: 162: 45.07
+	Hs
		880408 AP2B1_HUMAN (33-935): 0: 669: 16.31		AP1S2_HUMAN (2-142): 4.11e-51: 161: 46.81
+	Hs
		925978 AP2B1_HUMAN (33-935): 0: 669: 16.31		AP1S3_HUMAN (1-142): 1.17e-49: 157: 43.66
+	Hs
		925992 AP2B1_HUMAN (33-935): 0: 669: 16.31		AP1M1_HUMAN (2-137): 3.51e-44: 151: 14.71
+	Hs
		926066 AP2B1_HUMAN (33-935): 0: 669: 16.31		AP1M2_HUMAN (2-142): 2.73e-44: 151: 20.14
+	Hs
		864065 AP2B1_HUMAN (33-935): 0: 669: 16.31		AP2S1_HUMAN (1-142): 4.85e-46: 148: 95.78
+	Sc
		743403 AP2A_YEAST (9-938): 0: 669: 24.93		AP2S_YEAST (2-142): 1.34e-45: 147: 48.28
+	Hs
		880409 AP1B1_HUMAN (33-935): 0: 654: 15.41		AP1S2_HUMAN (2-142): 4.11e-51: 161: 46.81
+	Hs
		925969 AP2B1_HUMAN (33-935): 0: 669: 16.31		AP2M1_HUMAN (1-138): 1.51e-41: 144: 15.22
+	Hs
		864070 AP1B1_HUMAN (33-935): 0: 654: 15.41		AP2S1_HUMAN (1-142): 4.85e-46: 148: 95.78