HitPredict

Interactor 1: RAB5B (P61020)
Ras-related protein Rab-5B (EC 3.6.5.2)
Gene: RAB5B

Interactor 2: OPTN (Q96CV9)
Optineurin (E3-14.7K-interacting protein) (FIP-2) (Huntingtin yeast partner L) (Huntingtin-interacting protein 7) (HIP-7) (Huntingtin-interacting protein L) (NEMO-related protein) (Optic neuropathy-inducing protein) (Transcription factor IIIA-interacting protein) (TFIIIA-IntP)
Gene: OPTN

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.437

Property	Details
Experiments	31723608
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 215 Hs			1 577
+	Hs
		955928 RAB8A_HUMAN (14-211): 3.46e-85: 252: 34.85		DCTN1_HUMAN (199-553): 4.08e-55: 203: 17.53
+	Hs
		956291 RAB2A_HUMAN (17-208): 3.63e-82: 245: 37.50		DCTN1_HUMAN (199-553): 4.08e-55: 203: 17.53
+	Hs
		1386576 RAB1B_HUMAN (13-213): 2.31e-86: 255: 39.30		OPTN_HUMAN (1-577): 1.55e-48: 179: 100.00
+	Hs
		955989 RAB8A_HUMAN (14-211): 3.46e-85: 252: 34.85		OPTN_HUMAN (1-577): 1.55e-48: 179: 100.00
+	Hs
		976480 RB11A_HUMAN (10-215): 1.7e-83: 248: 38.61		OPTN_HUMAN (1-577): 1.55e-48: 179: 100.00
+	Mm
		976721 RB11A_MOUSE (10-215): 1.7e-83: 248: 38.61		OPTN_MOUSE (1-577): 1.84e-40: 156: 75.64
+	Hs
		956037 RAB8A_HUMAN (14-211): 3.46e-85: 252: 34.85		NEMO_HUMAN (204-576): 8.62e-37: 143: 25.86
+	Hs
		976708 RB11A_HUMAN (10-215): 1.7e-83: 248: 38.61		NEMO_HUMAN (204-576): 8.62e-37: 143: 25.86
+	Hs
		976324 RB11A_HUMAN (10-215): 1.7e-83: 248: 38.61		MRCKA_HUMAN (88-519): 4.82e-27: 118: 14.89
+	Hs
		956337 RAB2A_HUMAN (17-208): 3.63e-82: 245: 37.50		MRCKA_HUMAN (88-519): 4.82e-27: 118: 14.89
+	Dm
		1070921 RAB5_DROME (3-213): 2.36e-97: 283: 72.51		Q0KI67_DROME (50-545): 9.1e-10: 63.9: 11.74
+	Hs
		157196 RAB1A_HUMAN (10-213): 9.39e-88: 258: 39.51		CTRO_HUMAN (129-555): 4.55e-11: 68.3: 12.36
+	Hs
		956013 RAB8A_HUMAN (14-211): 3.46e-85: 252: 34.85		MYO5C_HUMAN (39-462): 1.82e-12: 72.8: 15.10
+	Hs
		156949 RAB5A_HUMAN (1-215): 1.29e-86: 256: 81.86		CTRO_HUMAN (129-555): 4.55e-11: 68.3: 12.36
+	Hs
		157837 RAB1B_HUMAN (13-213): 2.31e-86: 255: 39.30		CTRO_HUMAN (129-555): 4.55e-11: 68.3: 12.36
+	Hs
		976302 RB11A_HUMAN (10-215): 1.7e-83: 248: 38.61		GRDN_HUMAN (18-566): 5.48e-13: 74.4: 9.79
+	Hs
		976588 RB11A_HUMAN (10-215): 1.7e-83: 248: 38.61		MYO5C_HUMAN (39-462): 1.82e-12: 72.8: 15.10
+	Hs
		956319 RAB2A_HUMAN (17-208): 3.63e-82: 245: 37.50		GRDN_HUMAN (18-566): 5.48e-13: 74.4: 9.79
+	Hs
		270793 RB11A_HUMAN (10-215): 1.7e-83: 248: 38.61		ROCK2_HUMAN (13-422): 5.48e-09: 61.5: 12.15
+	Hs
		270790 RAB2A_HUMAN (17-208): 3.63e-82: 245: 37.50		ROCK2_HUMAN (13-422): 5.48e-09: 61.5: 12.15