HitPredict

Interactor 1: PFKAP (Q01813)
ATP-dependent 6-phosphofructokinase, platelet type (ATP-PFK) (PFK-P) (EC 2.7.1.11) (6-phosphofructokinase type C) (Phosphofructo-1-kinase isozyme C) (PFK-C) (Phosphohexokinase)
Gene: PFKP

Interactor 2: NTRK3 (Q16288)
NT-3 growth factor receptor (EC 2.7.10.1) (GP145-TrkC) (Trk-C) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase)
Gene: NTRK3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.500

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 784 Hs			1 839
+	Hs
		437757 PFKAM_HUMAN (13-779): 0: 1030: 71.78		NTRK3_HUMAN (1-839): 0: 671: 100.00
+	Hs
		384669 PFKAP_HUMAN (1-784): 0: 1093: 100.00		NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75
+	Hs
		601497 PFKAP_HUMAN (1-784): 0: 1093: 100.00		FGFR2_HUMAN (203-838): 1.97e-168: 510: 24.89
+	Hs
		507955 PFKAP_HUMAN (1-784): 0: 1093: 100.00		FGFR1_HUMAN (162-838): 5.94e-163: 496: 23.43
+	Hs
		607944 PFKAP_HUMAN (1-784): 0: 1093: 100.00		FGFR4_HUMAN (166-837): 6.43e-152: 466: 24.57
+	Hs
		384121 PFKAM_HUMAN (13-779): 0: 1030: 71.78		NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75
+	Hs
		411357 PFKAP_HUMAN (1-784): 0: 1093: 100.00		INSR_HUMAN (513-824): 1.34e-64: 238: 39.43
+	Hs
		435613 PFKAP_HUMAN (1-784): 0: 1093: 100.00		IGF1R_HUMAN (513-820): 3.56e-64: 236: 39.16
+	Hs
		966789 PFKAP_HUMAN (1-784): 0: 1093: 100.00		ALK_HUMAN (513-816): 2.78e-59: 222: 39.03
+	Hs
		411276 PFKAM_HUMAN (13-779): 0: 1030: 71.78		INSR_HUMAN (513-824): 1.34e-64: 238: 39.43
+	Mm
		519479 PFKAL_MOUSE (19-779): 0: 1023: 69.42		PTK7_MOUSE (212-394): 3.12e-10: 66.3: 17.35
+	Hs
		384225 PFKAL_HUMAN (396-739): 1.72e-65: 234: 27.03		NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75
+	Hs
		571668 PFKAL_HUMAN (396-739): 1.72e-65: 234: 27.03		FGFR3_HUMAN (140-838): 3.83e-170: 514: 23.73
+	Hs
		571725 PFKAL_HUMAN (396-739): 1.72e-65: 234: 27.03		DDR2_HUMAN (527-824): 2.05e-70: 250: 43.30