Protein: ARHG1
Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5)

Gene: ARHG1, ARHGEF1
Organism: Homo sapiens
Interactions: 105
UniProt ID: Q92888

Gene Ontology (top 5):
GO:0001664 - G protein-coupled receptor binding
GO:0003723 - RNA binding
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005096 - GTPase activator activity
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

962346

RHOA
Transforming protein RhoA

6

20

Small-scale

0.944

High

1125910

GNA13
Guanine nucleotide-binding protein subunit alpha-13

5

19

Small-scale

0.922

High

978212

RHOB
Rho-related GTP-binding protein RhoB

4

20

Small-scale

0.883

High

466394

RHOC
Rho-related GTP-binding protein RhoC

2

20

High-throughput

0.811

High

1040975

GNA12
Guanine nucleotide-binding protein subunit alpha-12

2

19

Small-scale

0.799

High

1323640

DOCK4
Dedicator of cytokinesis protein 4

2

4

High-throughput

0.754

High

389463

FINC
Fibronectin

1

8

High-throughput

0.691

High

610427

PRS6A
26S proteasome regulatory subunit 6A

3

2

High-throughput

0.667

High

471466

PLEK
Pleckstrin

1

10

High-throughput

0.665

High

374827

RASH
GTPase HRas

1

17

Small-scale

0.647

High

982116

RAP1A
Ras-related protein Rap-1A

1

20

Small-scale

0.647

High

893515

GNAQ
Guanine nucleotide-binding protein G(q) subunit alpha

1

20

Small-scale

0.618

High

942795

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

20

High-throughput

0.618

High

1254908

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.618

High

1369927

ARHG1
Rho guanine nucleotide exchange factor 1

1

17

Small-scale

0.618

High

1369944

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.618

High

1308247

CCNJL
Cyclin-J-like protein

2

6

High-throughput

0.611

High

888474

TSP3
Thrombospondin-3

3

3

High-throughput

0.609

High

242484

PRKN
E3 ubiquitin-protein ligase parkin

2

11

High-throughput

0.584

High

245808

PI51C
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma

2

3

High-throughput

0.571

High

1246490

BL1S2
Biogenesis of lysosome-related organelles complex 1 subunit 2

2

2

High-throughput

0.571

High

1369952

WBP11
WW domain-binding protein 11

2

4

High-throughput

0.571

High

1042590

PTPS
6-pyruvoyl tetrahydrobiopterin synthase

2

0

High-throughput

0.547

High

1369940

RM04
Large ribosomal subunit protein uL4m

2

0

High-throughput

0.547

High

1085456

SRBP2
Sterol regulatory element-binding protein 2

1

3

High-throughput

0.541

High

158482

RFXK
DNA-binding protein RFXANK

1

11

High-throughput

0.536

High

457597

TBB5
Tubulin beta chain

1

7

High-throughput

0.536

High

854202

KI67
Proliferation marker protein Ki-67

1

8

High-throughput

0.536

High

922600

AP2S1
AP-2 complex subunit sigma

1

8

High-throughput

0.536

High

1111158

SNW1
SNW domain-containing protein 1

1

2

High-throughput

0.536

High

1280205

MILR1
Allergin-1

1

2

High-throughput

0.536

High

1310281

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.536

High

1369931

EFMT3
EEF1A lysine methyltransferase 3

1

4

High-throughput

0.536

High

1369933

DCNL1
DCN1-like protein 1

1

1

High-throughput

0.536

High

1369935

CDC5L
Cell division cycle 5-like protein

1

4

High-throughput

0.536

High

1369938

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

19

High-throughput

0.536

High

1369939

DUS16
Dual specificity protein phosphatase 16

1

1

High-throughput

0.536

High

1369941

UBXN6
UBX domain-containing protein 6

1

2

High-throughput

0.536

High

350617

TXD12
Thioredoxin domain-containing protein 12

2

2

High-throughput

0.521

High

669963

MCM3
DNA replication licensing factor MCM3

2

9

High-throughput

0.521

High

1369934

CLCC1
Chloride channel CLIC-like protein 1

2

1

High-throughput

0.521

High

239164

ZNRD2
Protein ZNRD2

1

0

High-throughput

0.513

High

1349608

NT5C
5'(3')-deoxyribonucleotidase, cytosolic type

1

0

High-throughput

0.513

High

1369928

VPP1
V-type proton ATPase 116 kDa subunit a 1

1

0

High-throughput

0.513

High

1369946

DMAP1
DNA methyltransferase 1-associated protein 1

1

0

High-throughput

0.513

High

885858

KC1E
Casein kinase I isoform epsilon

1

13

High-throughput

0.508

High

143968

EST2
Cocaine esterase

1

4

High-throughput

0.489

High

603673

JUNB
Transcription factor JunB

1

1

High-throughput

0.489

High

1041785

PPARD
Peroxisome proliferator-activated receptor delta

1

13

High-throughput

0.489

High

1177053

INF2
Inverted formin-2

1

6

High-throughput

0.489

High

1291939

WDR5B
WD repeat-containing protein 5B

1

15

High-throughput

0.489

High

1323917

KLH34
Kelch-like protein 34

1

11

High-throughput

0.489

High

1369936

NPAS1
Neuronal PAS domain-containing protein 1

1

1

High-throughput

0.489

High

1369951

PSG11
Pregnancy-specific beta-1-glycoprotein 11

1

2

High-throughput

0.489

High

173163

XPO1
Exportin-1

1

18

High-throughput

0.479

High

290660

SURF6
Surfeit locus protein 6

1

2

High-throughput

0.479

High

337003

AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1

1

1

Small-scale

0.479

High

412377

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.479

High

459708

PROF1
Profilin-1

1

6

High-throughput

0.479

High

591339

CD44
CD44 antigen

1

5

Small-scale

0.479

High

606972

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

648215

NDKB
Nucleoside diphosphate kinase B

1

2

High-throughput

0.479

High

656212

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

8

High-throughput

0.479

High

839062

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

8

Small-scale

0.479

High

966703

1433G
14-3-3 protein gamma

1

20

High-throughput

0.479

High

973071

RS29
Small ribosomal subunit protein uS14

1

2

High-throughput

0.479

High

1091641

TAF10
Transcription initiation factor TFIID subunit 10

1

2

High-throughput

0.479

High

1107989

SQSTM
Sequestosome-1

1

7

High-throughput

0.479

High

1134669

NUMA1
Nuclear mitotic apparatus protein 1

1

19

High-throughput

0.479

High

1138463

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

6

High-throughput

0.479

High

1217171

RIF1
Telomere-associated protein RIF1

1

13

High-throughput

0.479

High

1249073

LMBRL
Protein LMBR1L

1

1

High-throughput

0.479

High

1333301

NHLC2
NHL repeat-containing protein 2

1

1

High-throughput

0.479

High

1361199

DNJC9
DnaJ homolog subfamily C member 9

1

5

High-throughput

0.479

High

1369929

FBXW7
F-box/WD repeat-containing protein 7

1

14

High-throughput

0.479

High

1369930

LRC59
Leucine-rich repeat-containing protein 59

1

9

High-throughput

0.479

High

1369932

SH3K1
SH3 domain-containing kinase-binding protein 1

1

19

Small-scale

0.479

High

1369942

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

2

High-throughput

0.479

High

1369943

GAN
Gigaxonin

1

9

High-throughput

0.479

High

1369948

CTNL1
Alpha-catulin

1

7

Small-scale

0.479

High

1369949

ZRAN1
Ubiquitin thioesterase ZRANB1

1

14

High-throughput

0.479

High

1369950

XPO7
Exportin-7

1

15

High-throughput

0.479

High

1161981

H31T
Histone H3.1t

1

2

High-throughput

0.470

High

1271769

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.458

High

397972

ANGI
Angiogenin

1

1

High-throughput

0.445

High

1185859

NSN5B
Putative NOL1/NOP2/Sun domain family member 5B

1

2

High-throughput

0.445

High

1369945

S6A20
Sodium- and chloride-dependent transporter XTRP3

1

1

High-throughput

0.445

High

372746

MYC
Myc proto-oncogene protein

1

12

High-throughput

0.437

High

418326

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

1

High-throughput

0.437

High

589318

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.437

High

696113

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.437

High

768803

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

879327

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

4

High-throughput

0.437

High

1042042

LMNB2
Lamin-B2

1

11

High-throughput

0.437

High

1276582

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

7

High-throughput

0.437

High

1310098

MGAP
MAX gene-associated protein

1

2

High-throughput

0.437

High

1369947

QPCTL
Glutaminyl-peptide cyclotransferase-like protein

1

1

High-throughput

0.437

High

1369954

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

2

High-throughput

0.437

High

65414

MFS2B
Sphingosine-1-phosphate transporter MFSD2B

1

0

High-throughput

0.426

High

1212431

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

1

High-throughput

0.407

High

1109483

ATR
Serine/threonine-protein kinase ATR

1

7

Small-scale

0.373

High

587167

ITF2
Transcription factor 4

1

0

High-throughput

0.299

High

1369937

MND1
Meiotic nuclear division protein 1 homolog

1

0

High-throughput

0.279

Low

1369953

RT18C
Small ribosomal subunit protein bS18m

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025