HitPredict

Interactor 1: SMD3 (P62318)
Small nuclear ribonucleoprotein Sm D3 (Sm-D3) (snRNP core protein D3)
Gene: SNRPD3

Interactor 2: SYF1 (Q9HCS7)
Pre-mRNA-splicing factor SYF1 (Protein HCNP) (XPA-binding protein 2)
Gene: XAB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0071007 - U2-type catalytic step 2 spliceosome GO:0071013 - catalytic step 2 spliceosome
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 126 Hs			1 855
+	Hs
		974053 RUXF_HUMAN (1-72): 4.66e-28: 100: 24.66		SYF1_HUMAN (1-855): 0: 603: 100.00
+	Sc
		847829 SMD3_YEAST (4-102): 3.27e-30: 105: 43.43		SYF1_YEAST (19-733): 1.31e-87: 298: 22.31
+	Sc
		1036175 SMD1_YEAST (7-97): 6.78e-11: 57.8: 22.03		SYF1_YEAST (19-733): 1.31e-87: 298: 22.31
+	Hs
		1419986 LSM2_HUMAN (8-91): 1.44e-30: 106: 22.09		CRNL1_HUMAN (166-822): 5.01e-47: 182: 14.51
+	Hs
		974040 RUXF_HUMAN (1-72): 4.66e-28: 100: 24.66		CRNL1_HUMAN (166-822): 5.01e-47: 182: 14.51
+	Hs
		974744 SMD3_HUMAN (1-126): 1.78e-42: 137: 100.00		SART3_HUMAN (18-578): 1.71e-31: 134: 12.80
+	Hs
		973951 RUXF_HUMAN (1-72): 4.66e-28: 100: 24.66		CTR9_HUMAN (44-847): 3.47e-41: 165: 10.93
+	Hs
		321488 SMD3_HUMAN (1-126): 1.78e-42: 137: 100.00		PRP6_HUMAN (2-353): 4.03e-26: 117: 12.92
+	Hs
		1137209 LSM4_HUMAN (5-84): 8.79e-35: 118: 30.86		SART3_HUMAN (18-578): 1.71e-31: 134: 12.80
+	Hs
		1137203 LSM2_HUMAN (8-91): 1.44e-30: 106: 22.09		SART3_HUMAN (18-578): 1.71e-31: 134: 12.80
+	Hs
		321707 LSM4_HUMAN (5-84): 8.79e-35: 118: 30.86		PRP6_HUMAN (2-353): 4.03e-26: 117: 12.92
+	Hs
		973917 RUXF_HUMAN (1-72): 4.66e-28: 100: 24.66		SART3_HUMAN (18-578): 1.71e-31: 134: 12.80
+	Hs
		321701 LSM2_HUMAN (8-91): 1.44e-30: 106: 22.09		PRP6_HUMAN (2-353): 4.03e-26: 117: 12.92
+	Hs
		321483 RUXF_HUMAN (1-72): 4.66e-28: 100: 24.66		PRP6_HUMAN (2-353): 4.03e-26: 117: 12.92
+	Sp
		1084850 SMD3_SCHPO (3-99): 3.77e-32: 110: 59.79		PRP1_SCHPO (3-435): 5.01e-19: 94.7: 13.66
+	Sp
		206001 SMD1_SCHPO (7-94): 1.14e-31: 110: 23.86		PRP1_SCHPO (3-435): 5.01e-19: 94.7: 13.66
+	Sc
		847845 SMD3_YEAST (4-102): 3.27e-30: 105: 43.43		CLF1_YEAST (3-250): 4.8e-11: 68.5: 12.06
+	Sc
		795944 LSM2_YEAST (8-90): 6.77e-27: 97.3: 17.65		CLF1_YEAST (3-250): 4.8e-11: 68.5: 12.06
+	Sc
		1036190 SMD1_YEAST (7-97): 6.78e-11: 57.8: 22.03		CLF1_YEAST (3-250): 4.8e-11: 68.5: 12.06