HitPredict

Interactor 1: H4 (P62805)
Histone H4
Gene: H4C1

Interactor 2: SHPRH (Q149N8)
E3 ubiquitin-protein ligase SHPRH (EC 2.3.2.27) (EC 3.6.4.-) (RING-type E3 ubiquitin transferase SHPRH) (SNF2, histone-linker, PHD and RING finger domain-containing helicase)
Gene: SHPRH

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	1.00	0.853

Property	Details
Experiments	31434570, 28514442, 33961781
Identification Methods	enzymatic study, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	CENP-T_C~SNF2-rel_dom
Common GO terms	GO:0000786 - nucleosome GO:0003677 - DNA binding GO:0005654 - nucleoplasm GO:0006334 - nucleosome assembly
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 103 Hs			1 1683
+	Hs
		979570 H4_HUMAN (1-103): 1.39e-48: 151: 100.00		CHD3_HUMAN (1240-1682): 1.32e-103: 370: 16.67
+	Hs
		243587 H4_HUMAN (1-103): 1.39e-48: 151: 100.00		SMCA5_HUMAN (1267-1682): 9.74e-107: 369: 15.44
+	Hs
		979665 H4_HUMAN (1-103): 1.39e-48: 151: 100.00		CHD4_HUMAN (1240-1682): 1.01e-96: 348: 16.67
+	Hs
		980464 H4_HUMAN (1-103): 1.39e-48: 151: 100.00		CHD7_HUMAN (1172-1679): 3.6e-96: 348: 13.09
+	Hs
		980365 H4_HUMAN (1-103): 1.39e-48: 151: 100.00		CHD8_HUMAN (1288-1679): 9.61e-96: 346: 15.64
+	Hs
		980029 H4_HUMAN (1-103): 1.39e-48: 151: 100.00		CHD6_HUMAN (1286-1679): 3.39e-95: 345: 15.60
+	Hs
		903303 H4_HUMAN (1-103): 1.39e-48: 151: 100.00		SMCA4_HUMAN (1246-1682): 5.7e-94: 339: 13.91
+	Hs
		979752 H4_HUMAN (1-103): 1.39e-48: 151: 100.00		CHD9_HUMAN (1288-1679): 5.55e-92: 335: 15.88
+	Sc
		382398 H4_YEAST (18-103): 6.16e-41: 132: 90.70		ISW2_YEAST (1156-1682): 4.1e-98: 345: 12.66
+	Hs
		160171 H4_HUMAN (1-103): 1.39e-48: 151: 100.00		CHD2_HUMAN (1273-1682): 2.54e-81: 299: 16.28
+	Sc
		381871 H4_YEAST (18-103): 6.16e-41: 132: 90.70		SNF2_YEAST (1248-1682): 4.79e-81: 298: 14.45
+	Hs
		979867 H4_HUMAN (1-103): 1.39e-48: 151: 100.00		SRCAP_HUMAN (1476-1675): 3.94e-61: 235: 18.63
+	Sc
		381933 H4_YEAST (18-103): 6.16e-41: 132: 90.70		RAD16_YEAST (709-987): 3.75e-64: 236: 20.13
+	Hs
		980545 H4_HUMAN (1-103): 1.39e-48: 151: 100.00		TTF2_HUMAN (1507-1675): 3.1e-52: 204: 27.75
+	Sc
		382368 H4_YEAST (18-103): 6.16e-41: 132: 90.70		IRC20_YEAST (1407-1644): 1.7e-51: 202: 26.03
+	Hs
		980403 H4_HUMAN (1-103): 1.39e-48: 151: 100.00		HELLS_HUMAN (689-1006): 1.52e-25: 117: 15.67
+	Hs
		979649 H4_HUMAN (1-103): 1.39e-48: 151: 100.00		HLTF_HUMAN (265-390): 1.25e-10: 68.6: 28.57
+	Sp
		206383 H4_SCHPO (18-103): 4.89e-42: 135: 89.54		FFT3_SCHPO (1516-1663): 1.55e-12: 74.7: 32.90
+	Sc
		381939 H4_YEAST (18-103): 6.16e-41: 132: 90.70		BTAF1_YEAST (1499-1675): 1.75e-12: 75.1: 30.98