Protein: IRC20
Uncharacterized ATP-dependent helicase IRC20 (EC 3.6.1.-) (Increased recombination centers protein 20)

Gene: IRC20
Organism: Saccharomyces cerevisiae S288C
Interactions: 98
UniProt ID: Q06554

Gene Ontology (top 5):
GO:0004386 - helicase activity
GO:0004842 - ubiquitin-protein transferase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

382368

H4
Histone H4

4

19

Small-scale

0.886

High

419516

H2A1
Histone H2A.1

1

20

High-throughput

0.691

High

509731

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

12

Small-scale

0.647

High

948667

ACT
Actin

1

20

High-throughput

0.646

High

381279

H2B1
Histone H2B.1

1

20

High-throughput

0.618

High

381644

H2B2
Histone H2B.2

1

20

High-throughput

0.618

High

419885

H2A2
Histone H2A.2

1

20

High-throughput

0.618

High

459170

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

4

High-throughput

0.618

High

534312

RPA1
DNA-directed RNA polymerase I subunit RPA190

1

10

Small-scale

0.618

High

917488

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

1

8

Small-scale

0.618

High

1044471

RUVB1
RuvB-like protein 1

1

14

Small-scale

0.618

High

1055693

H2AZ
Histone H2A.Z

1

20

High-throughput

0.618

High

924251

IPI3
Pre-rRNA-processing protein IPI3

1

11

High-throughput

0.575

High

676382

MAS5
Mitochondrial protein import protein MAS5

2

14

Small-scale

0.571

High

815337

IF4F2
Eukaryotic initiation factor 4F subunit p130

1

15

Small-scale

0.553

High

828619

YAP4
AP-1-like transcription factor YAP4

1

0

High-throughput

0.513

High

425154

OTC
Ornithine carbamoyltransferase

1

3

High-throughput

0.500

High

518137

SSBP1
Single-stranded nucleic acid-binding protein

1

20

High-throughput

0.500

High

1048242

SOV1
Protein SOV1, mitochondrial

1

0

High-throughput

0.479

High

367128

ATPB
ATP synthase subunit beta, mitochondrial

1

11

Small-scale

0.479

High

367815

ENO1
Enolase 1

1

2

Small-scale

0.479

High

416284

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

3

Small-scale

0.479

High

439168

ILV5
Ketol-acid reductoisomerase, mitochondrial

1

1

Small-scale

0.479

High

453806

PYR1
Multifunctional protein URA2

1

5

Small-scale

0.479

High

471439

ARO1
Pentafunctional AROM polypeptide [Includes: 3-dehydroquinate synthase

1

1

Small-scale

0.479

High

566521

DHAS
Aspartate-semialdehyde dehydrogenase

1

1

Small-scale

0.479

High

580121

HSC82
ATP-dependent molecular chaperone HSC82

1

13

Small-scale

0.479

High

592518

VATB
V-type proton ATPase subunit B

1

11

Small-scale

0.479

High

599080

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

2

Small-scale

0.479

High

648407

SYMM
Methionine--tRNA ligase, mitochondrial

1

9

High-throughput

0.479

High

655643

TAF2
Transcription initiation factor TFIID subunit 2

1

3

High-throughput

0.479

High

664353

SSD1
Protein SSD1

1

4

Small-scale

0.479

High

673388

NFS1
Cysteine desulfurase, mitochondrial

1

3

Small-scale

0.479

High

678747

PAT1
Deadenylation-dependent mRNA-decapping factor PAT1

1

4

Small-scale

0.479

High

680090

CDC48
Cell division control protein 48

1

6

Small-scale

0.479

High

692632

NSR1
Nuclear localization sequence-binding protein

1

15

Small-scale

0.479

High

708279

TF2B
Transcription initiation factor IIB

1

7

High-throughput

0.479

High

739097

PAN1
Actin cytoskeleton-regulatory complex protein PAN1

1

6

Small-scale

0.479

High

745888

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

13

High-throughput

0.479

High

790231

GLYC
Serine hydroxymethyltransferase, cytosolic

1

2

Small-scale

0.479

High

795928

LSM2
LSM complex subunit LSM2

1

6

Small-scale

0.479

High

802700

YHI0
Putative proline--tRNA ligase YHR020W

1

6

Small-scale

0.479

High

816097

DLD3
D-2-hydroxyglutarate--pyruvate transhydrogenase DLD3

1

1

Small-scale

0.479

High

817508

ALDH5
Aldehyde dehydrogenase 5, mitochondrial

1

2

Small-scale

0.479

High

825836

YRB2
Ran-specific GTPase-activating protein 2

1

1

High-throughput

0.479

High

830190

NOP2
25S rRNA

1

4

Small-scale

0.479

High

1044769

SCC2
Sister chromatid cohesion protein 2

1

3

High-throughput

0.479

High

1045170

SIZ1
E3 SUMO-protein ligase SIZ1

1

9

High-throughput

0.479

High

1046938

POB3
FACT complex subunit POB3

1

9

High-throughput

0.479

High

1052972

ARPC3
Actin-related protein 2/3 complex subunit 3

1

1

Small-scale

0.479

High

1054037

SFH1
Chromatin structure-remodeling complex subunit SFH1

1

12

High-throughput

0.479

High

1055686

MDM38
Mitochondrial distribution and morphology protein 38

1

2

High-throughput

0.479

High

1055687

ESA1
Histone acetyltransferase ESA1

1

10

High-throughput

0.479

High

1055689

SIZ2
E3 SUMO-protein ligase SIZ2

1

8

High-throughput

0.479

High

1055690

SMT3
Ubiquitin-like protein SMT3

1

17

Small-scale

0.479

High

858294

ARC1
tRNA-aminoacylation cofactor ARC1

1

2

High-throughput

0.470

High

574931

SAM35
Sorting assembly machinery 35 kDa subunit

1

0

High-throughput

0.458

High

780061

EAP1
Protein EAP1

1

0

Small-scale

0.458

High

830027

LYS14
Lysine biosynthesis regulatory protein LYS14

1

0

High-throughput

0.458

High

865757

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.458

High

866021

ADK
Adenosine kinase

1

0

Small-scale

0.458

High

1048812

ROY1
Non-SCF-type F-box protein ROY1

1

0

High-throughput

0.458

High

1055688

ACEB
Mitochondrial 2-methylisocitrate lyase ICL2

1

0

High-throughput

0.458

High

1055691

MED1
Mediator of RNA polymerase II transcription subunit 1

1

0

High-throughput

0.458

High

405147

LEU3
3-isopropylmalate dehydrogenase

1

5

High-throughput

0.457

High

393383

HSP82
ATP-dependent molecular chaperone HSP82

1

13

High-throughput

0.445

High

525260

HSP71
Heat shock protein SSA1

1

20

High-throughput

0.445

High

527772

HSP72
Heat shock protein SSA2

1

20

High-throughput

0.445

High

546407

SSB1
Ribosome-associated molecular chaperone SSB1

1

20

High-throughput

0.445

High

727339

HS104
Heat shock protein 104

1

8

High-throughput

0.445

High

742477

HSP7F
Heat shock protein homolog SSE1

1

20

High-throughput

0.445

High

819889

SSB2
Ribosome-associated molecular chaperone SSB2

1

20

High-throughput

0.445

High

824561

6P21
6-phosphofructo-2-kinase 1

1

5

High-throughput

0.445

High

925082

APJ1
J domain-containing protein APJ1

1

14

High-throughput

0.445

High

430930

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

5

Small-scale

0.437

High

434197

RL36A
Large ribosomal subunit protein eL36A

1

5

Small-scale

0.437

High

454240

LEUC
3-isopropylmalate dehydratase

1

3

Small-scale

0.437

High

511701

RS23B
Small ribosomal subunit protein uS12B

1

1

Small-scale

0.437

High

513914

RS11B
Small ribosomal subunit protein uS17B

1

3

High-throughput

0.437

High

585389

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

6

Small-scale

0.437

High

618921

ARF2
ADP-ribosylation factor 2

1

1

Small-scale

0.437

High

734209

EF2
Elongation factor 2

1

9

Small-scale

0.437

High

737780

IF2G
Eukaryotic translation initiation factor 2 subunit gamma

1

8

Small-scale

0.437

High

799697

TSL1
Trehalose synthase complex regulatory subunit TSL1

1

1

Small-scale

0.437

High

820967

RL13B
Large ribosomal subunit protein eL13B

1

4

Small-scale

0.437

High

850399

YFI6
Uncharacterized protein YFR016C

1

12

Small-scale

0.437

High

924106

CNM67
Chaotic nuclear migration protein 67

1

11

High-throughput

0.437

High

1050175

RRP5
rRNA biogenesis protein RRP5

1

11

Small-scale

0.437

High

1055692

RL13A
Large ribosomal subunit protein eL13A

1

4

Small-scale

0.437

High

1051545

NSE3
Non-structural maintenance of chromosome element 3

1

0

High-throughput

0.426

High

863757

PFD1
Prefoldin subunit 1

1

1

High-throughput

0.407

High

624860

EXO70
Exocyst complex component EXO70

1

0

High-throughput

0.279

Low

550773

INO1
Inositol-3-phosphate synthase

1

0

High-throughput

0.249

Low

752030

PGM1
Phosphoglucomutase 1

1

0

High-throughput

0.249

Low

754138

HIS5
Imidazole glycerol phosphate synthase hisHF

1

0

High-throughput

0.249

Low

818230

DSE1
Protein DSE1

1

0

High-throughput

0.249

Low

820285

PPN2
Zinc-dependent endopolyphosphatase

1

0

High-throughput

0.249

Low

1043489

YM59
Uncharacterized protein YMR209C

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025