HitPredict

Interactor 1: H4 (P62805)
Histone H4
Gene: H4C1

Interactor 2: HDAC5 (Q9UQL6)
Histone deacetylase 5 (HD5) (EC 3.5.1.98) (Antigen NY-CO-9)
Gene: HDAC5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.633

Property	Details
Experiments	37351164, 21081666, 10220385
Identification Methods	affinity chromatography technology, deacetylase assay
Interaction Type	physical association, deacetylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 103 Hs			1 1122
+	Hs
		940901 H4_HUMAN (1-103): 1.39e-48: 151: 100.00		HDAC4_HUMAN (1-1101): 0: 648: 55.61
+	Hs
		980523 H4_HUMAN (1-103): 1.39e-48: 151: 100.00		HDAC9_HUMAN (25-1055): 0: 605: 55.58
+	Hs
		980076 H4_HUMAN (1-103): 1.39e-48: 151: 100.00		HDAC2_HUMAN (672-1113): 1.1e-153: 469: 21.30
+	Mm
		148671 H4_MOUSE (1-103): 1.39e-48: 151: 100.00		HDAC1_MOUSE (673-1103): 2.27e-153: 468: 21.16
+	Hs
		979614 H4_HUMAN (1-103): 1.39e-48: 151: 100.00		HDAC1_HUMAN (673-1103): 2.22e-153: 468: 21.16
+	Dm
		1014792 H4_DROME (1-103): 4.53e-48: 150: 99.03		HDAC1_DROME (676-1113): 6.85e-153: 468: 21.93
+	Mm
		980640 H4_MOUSE (1-103): 1.39e-48: 151: 100.00		HDAC2_MOUSE (672-1113): 3.83e-153: 467: 21.30
+	Hs
		188232 H4_HUMAN (1-103): 1.39e-48: 151: 100.00		HDAC3_HUMAN (679-1119): 2.86e-144: 442: 21.86
+	Sc
		381960 H4_YEAST (18-103): 6.16e-41: 132: 90.70		RPD3_YEAST (666-1098): 6.53e-146: 446: 22.05
+	Sc
		382267 H4_YEAST (18-103): 6.16e-41: 132: 90.70		HDA1_YEAST (658-1097): 1.13e-140: 442: 32.32
+	Hs
		980479 H4_HUMAN (1-103): 1.39e-48: 151: 100.00		HDAC6_HUMAN (599-1061): 3.7e-106: 362: 31.97
+	Sc
		382228 H4_YEAST (18-103): 6.16e-41: 132: 90.70		HOS2_YEAST (704-1005): 7.96e-24: 108: 28.39