HitPredict

Interactor 1: H4 (P62805)
Histone H4
Gene: H4C1

Interactor 2: HDAC6 (Q9UBN7)
Protein deacetylase HDAC6 (EC 3.5.1.-) (E3 ubiquitin-protein ligase HDAC6) (EC 2.3.2.-) (Tubulin-lysine deacetylase HDAC6) (EC 3.5.1.-)
Gene: HDAC6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	35676659, 37503842, 21090589, 10220385
Identification Methods	affinity chromatography technology, unspecified method, deacetylase assay
Interaction Type	physical association, direct interaction, deacetylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 103 Hs			1 1215
+	Mm
		148671 H4_MOUSE (1-103): 1.39e-48: 151: 100.00		HDAC1_MOUSE (80-482): 4.71e-166: 503: 20.94
+	Hs
		979614 H4_HUMAN (1-103): 1.39e-48: 151: 100.00		HDAC1_HUMAN (80-482): 4.66e-166: 503: 20.71
+	Dm
		1014792 H4_DROME (1-103): 4.53e-48: 150: 99.03		HDAC1_DROME (79-483): 4.98e-159: 486: 19.01
+	Hs
		980076 H4_HUMAN (1-103): 1.39e-48: 151: 100.00		HDAC2_HUMAN (78-489): 3.62e-158: 483: 20.74
+	Mm
		980640 H4_MOUSE (1-103): 1.39e-48: 151: 100.00		HDAC2_MOUSE (78-489): 2.87e-157: 480: 20.74
+	Hs
		940901 H4_HUMAN (1-103): 1.39e-48: 151: 100.00		HDAC4_HUMAN (405-873): 3.54e-147: 473: 36.51
+	Hs
		980553 H4_HUMAN (1-103): 1.39e-48: 151: 100.00		HDAC5_HUMAN (33-471): 8.24e-146: 471: 32.48
+	Hs
		188232 H4_HUMAN (1-103): 1.39e-48: 151: 100.00		HDAC3_HUMAN (479-890): 1.13e-146: 450: 18.29
+	Sc
		382267 H4_YEAST (18-103): 6.16e-41: 132: 90.70		HDA1_YEAST (80-456): 5.08e-148: 464: 33.17
+	Sc
		381960 H4_YEAST (18-103): 6.16e-41: 132: 90.70		RPD3_YEAST (83-473): 6.21e-150: 459: 20.63
+	Hs
		980523 H4_HUMAN (1-103): 1.39e-48: 151: 100.00		HDAC9_HUMAN (7-432): 1.28e-135: 440: 33.19
+	Hs
		980270 H4_HUMAN (1-103): 1.39e-48: 151: 100.00		HDAC8_HUMAN (103-388): 4.44e-19: 92.8: 26.67