HitPredict

Interactor 1: HDAC4 (P56524)
Histone deacetylase 4 (HD4) (EC 3.5.1.98)
Gene: HDAC4

Interactor 2: H4 (P62805)
Histone H4
Gene: H4C1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	10220385
Identification Methods	deacetylase assay
Interaction Type	deacetylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 1084 Hs			1 103
+	Hs
		980523 HDAC9_HUMAN (25-1025): 0: 798: 56.25		H4_HUMAN (1-103): 1.39e-48: 151: 100.00
+	Hs
		980553 HDAC5_HUMAN (1-1084): 0: 784: 55.67		H4_HUMAN (1-103): 1.39e-48: 151: 100.00
+	Mm
		148671 HDAC1_MOUSE (646-1080): 6.83e-163: 491: 21.46		H4_MOUSE (1-103): 1.39e-48: 151: 100.00
+	Hs
		979614 HDAC1_HUMAN (646-1080): 6.41e-163: 491: 21.68		H4_HUMAN (1-103): 1.39e-48: 151: 100.00
+	Hs
		980076 HDAC2_HUMAN (647-1082): 1.1e-160: 486: 20.97		H4_HUMAN (1-103): 1.39e-48: 151: 100.00
+	Mm
		980640 HDAC2_MOUSE (647-1082): 3.67e-160: 484: 20.97		H4_MOUSE (1-103): 1.39e-48: 151: 100.00
+	Dm
		1014792 HDAC1_DROME (646-1081): 1.38e-159: 484: 20.75		H4_DROME (1-103): 4.53e-48: 150: 99.03
+	Hs
		188232 HDAC3_HUMAN (651-1083): 3.48e-150: 456: 20.62		H4_HUMAN (1-103): 1.39e-48: 151: 100.00
+	At
		947807 HDA6_ARATH (635-1077): 7.69e-150: 457: 19.44		H4_ARATH (1-103): 3.48e-48: 150: 98.06
+	Sc
		381960 RPD3_YEAST (637-1078): 2.87e-156: 472: 22.37		H4_YEAST (18-103): 6.16e-41: 132: 90.70
+	Sc
		382267 HDA1_YEAST (628-1045): 2.66e-146: 456: 35.99		H4_YEAST (18-103): 6.16e-41: 132: 90.70
+	Hs
		980479 HDAC6_HUMAN (574-1040): 3.46e-108: 367: 32.62		H4_HUMAN (1-103): 1.39e-48: 151: 100.00
+	Hs
		980270 HDAC8_HUMAN (669-962): 5.25e-24: 107: 27.22		H4_HUMAN (1-103): 1.39e-48: 151: 100.00
+	Sc
		382228 HOS2_YEAST (636-958): 3.35e-25: 112: 28.01		H4_YEAST (18-103): 6.16e-41: 132: 90.70