HitPredict

Interactor 1: TLE5 (Q08117)
TLE family member 5 (Amino-terminal enhancer of split) (Amino enhancer of split) (Gp130-associated protein GAM) (Grg-5) (Groucho-related protein 5) (Protein ESP1) (Protein GRG) (TLE family member 5, transcriptional modulator)
Gene: TLE5

Interactor 2: SIX1 (Q15475)
Homeobox protein SIX1 (Sine oculis homeobox homolog 1)
Gene: SIX1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.83	0.60	0.709

Property	Details
Experiments	25910212, 25416956, 32296183, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, two hybrid bait and prey pooling approach, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005667 - transcription regulator complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 197 Hs			1 284
+	Hs
		980756 TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50		SIX1_HUMAN (1-284): 4.94e-93: 278: 100.00
+	Hs
		980654 TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50		SIX2_HUMAN (1-284): 1.38e-82: 251: 72.97
+	Hs
		980881 TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50		SIX2_HUMAN (1-284): 1.38e-82: 251: 72.97
+	Hs
		315171 TLE4_HUMAN (2-191): 3.57e-112: 338: 68.59		SIX6_HUMAN (1-234): 8.65e-68: 212: 51.24
+	Hs
		315169 TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50		SIX6_HUMAN (1-234): 8.65e-68: 212: 51.24
+	Mm
		1143964 TLE4_MOUSE (2-191): 3.77e-112: 338: 68.59		SIX6_MOUSE (1-209): 4.21e-66: 208: 56.68
+	Mm
		1143691 TLE4_MOUSE (2-191): 3.77e-112: 338: 68.59		SIX3_MOUSE (1-250): 7.3e-64: 205: 51.18
+	Hs
		993614 TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00		SIX2_HUMAN (1-284): 1.38e-82: 251: 72.97
+	Hs
		1132994 Q5T3G3_HUMAN (2-197): 1.07e-99: 290: 61.43		SIX2_HUMAN (1-284): 1.38e-82: 251: 72.97
+	Hs
		311439 TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50		SIX3_HUMAN (1-250): 8.71e-64: 205: 51.18
+	Hs
		315170 TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50		SIX6_HUMAN (1-234): 8.65e-68: 212: 51.24
+	Hs
		315172 TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00		SIX6_HUMAN (1-234): 8.65e-68: 212: 51.24
+	Mm
		925832 TLE5_MOUSE (1-197): 2.66e-101: 292: 99.49		SIX6_MOUSE (1-209): 4.21e-66: 208: 56.68
+	Hs
		311440 TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00		SIX3_HUMAN (1-250): 8.71e-64: 205: 51.18
+	Mm
		925828 TLE5_MOUSE (1-197): 2.66e-101: 292: 99.49		SIX3_MOUSE (1-250): 7.3e-64: 205: 51.18
+	Hs
		822627 TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50		LHX1_HUMAN (27-276): 1.88e-43: 154: 13.49
+	Hs
		839732 TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50		LHX2_HUMAN (18-267): 5.52e-42: 150: 15.97
+	Hs
		980622 TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50		LHX8_HUMAN (24-263): 1.5e-38: 140: 16.67
+	Hs
		839735 TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00		LHX2_HUMAN (18-267): 5.52e-42: 150: 15.97
+	Dm
		558378 GROU_DROME (2-163): 3.54e-59: 198: 54.44		SO_DROME (2-271): 1.81e-72: 230: 63.70