Protein: A4
Amyloid-beta precursor protein (ABPP) (APP) (Alzheimer disease amyloid A4 protein homolog) (Alzheimer disease amyloid protein) (Amyloid precursor protein) (Amyloid-beta (A4) precursor protein) (Amyloid-beta A4 protein) (Amyloidogenic glycoprotein) (AG) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Gamma-CTF(50)); C31]

Gene: A4, App
Organism: Rattus norvegicus
Interactions: 11
UniProt ID: P08592

Gene Ontology (top 5):
GO:0000086 - G2/M transition of mitotic cell cycle
GO:0000278 - mitotic cell cycle
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001774 - microglial cell activation
GO:0001934 - positive regulation of protein phosphorylation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

441680

APBB1
Amyloid beta precursor protein binding family B member 1

4

14

Small-scale

0.870

High

421807

TNR16
Tumor necrosis factor receptor superfamily member 16

2

4

Small-scale

0.776

High

341604

TRY2
Anionic trypsin-2

1

12

Small-scale

0.647

High

193495

APBB3
Amyloid-beta A4 precursor protein-binding family B member 3

1

14

Small-scale

0.618

High

50284

A1L122
NEDD8-activating enzyme E1 regulatory subunit

1

5

Small-scale

0.479

High

70091

B2B9B0
receptor protein-tyrosine kinase

1

9

Small-scale

0.479

High

88586

D3ZE26
Transmembrane and coiled-coil domain family 2

1

2

Small-scale

0.479

High

441681

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

4

Small-scale

0.479

High

441683

Q8VID2
Puromycin-sensitive aminopeptidase

1

0

Small-scale

0.458

High

441679

TNFA
Tumor necrosis factor

1

2

Small-scale

0.445

High

441682

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin; Ubiquitin-related]

1

4

High-throughput

0.437

High


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Last updated: 15 Jul 2024