Protein: MFF
Mitochondrial fission factor

Gene: MFF
Organism: Homo sapiens
Interactions: 188
UniProt ID: Q9GZY8

Gene Ontology (top 5):
GO:0000266 - mitochondrial fission
GO:0005739 - mitochondrion
GO:0005741 - mitochondrial outer membrane
GO:0005777 - peroxisome
GO:0006626 - protein targeting to mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

135698

DNM1L
Dynamin-1-like protein

4

2

Small-scale

0.683

High

1429125

MFF
Mitochondrial fission factor

3

1

Small-scale

0.658

High

722611

CTR1
High affinity cationic amino acid transporter 1

3

2

High-throughput

0.647

High

1155037

ADIPO
Adiponectin

2

1

High-throughput

0.606

High

1279272

SPT19
Spermatogenesis-associated protein 19, mitochondrial

2

0

High-throughput

0.602

High

74193

SMIM1
Small integral membrane protein 1

2

0

High-throughput

0.580

High

189820

STX7
Syntaxin-7

2

0

High-throughput

0.580

High

209109

CYB5B
Cytochrome b5 type B

2

0

High-throughput

0.580

High

390752

TFR1
Transferrin receptor protein 1

2

0

High-throughput

0.580

High

688416

PPLA
Phospholamban

2

0

High-throughput

0.580

High

1216449

TSPO2
Translocator protein 2

2

0

High-throughput

0.580

High

1291487

RETR3
Reticulophagy regulator 3

2

0

High-throughput

0.580

High

1379878

FATE1
Fetal and adult testis-expressed transcript protein

2

0

High-throughput

0.580

High

1396398

F210B
Protein FAM210B, mitochondrial

2

0

High-throughput

0.580

High

1429133

PLCD
1-acyl-sn-glycerol-3-phosphate acyltransferase delta

2

0

High-throughput

0.580

High

1429143

TM14C
Transmembrane protein 14C

2

0

High-throughput

0.580

High

1429148

T3JAM
TRAF3-interacting JNK-activating modulator

2

0

High-throughput

0.580

High

1429151

TMX2
Thioredoxin-related transmembrane protein 2

2

0

High-throughput

0.580

High

1067041

MGT5A
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A

2

1

High-throughput

0.574

High

1388920

CC126
Coiled-coil domain-containing protein 126

2

1

High-throughput

0.574

High

1429142

MTCH1
Mitochondrial carrier homolog 1

2

1

High-throughput

0.571

High

1429156

MTCH2
Mitochondrial carrier homolog 2

2

1

High-throughput

0.571

High

1380150

FBXW7
F-box/WD repeat-containing protein 7

2

0

Small-scale

0.559

High

1382934

S2546
Mitochondrial outer membrane protein SLC25A46

2

0

Small-scale

0.559

High

1429141

MARH5
E3 ubiquitin-protein ligase MARCHF5

2

0

Small-scale

0.559

High

1429155

SAM50
Sorting and assembly machinery component 50 homolog

2

0

Small-scale

0.559

High

180043

BET1
BET1 homolog

2

1

High-throughput

0.553

High

252630

TSN2
Tetraspanin-2

2

1

High-throughput

0.553

High

280329

SC22B
Vesicle-trafficking protein SEC22b

2

1

High-throughput

0.553

High

295707

UPK1B
Uroplakin-1b

2

2

High-throughput

0.553

High

399488

OPSB
Short-wave-sensitive opsin 1

2

1

High-throughput

0.553

High

719085

MIP
Lens fiber major intrinsic protein

2

1

High-throughput

0.553

High

1109040

AQP6
Aquaporin-6

2

1

High-throughput

0.553

High

1295796

C1QL4
Complement C1q-like protein 4

2

1

High-throughput

0.553

High

1348636

S7A14
Solute carrier family 7 member 14

2

2

High-throughput

0.553

High

1351699

GP152
Probable G-protein coupled receptor 152

2

1

High-throughput

0.553

High

1363225

AQP3
Aquaporin-3

2

1

High-throughput

0.553

High

1394450

SC22A
Vesicle-trafficking protein SEC22a

2

1

High-throughput

0.553

High

1429144

LPAR3
Lysophosphatidic acid receptor 3

2

1

High-throughput

0.553

High

1429146

LAT2
Large neutral amino acids transporter small subunit 2

2

2

High-throughput

0.553

High

1429147

STX8
Syntaxin-8

2

1

High-throughput

0.553

High

396903

ESR1
Estrogen receptor

2

0

High-throughput

0.547

High

1094978

TRAF3
TNF receptor-associated factor 3

1

0

Small-scale

0.537

High

522133

BCL2
Apoptosis regulator Bcl-2

1

1

High-throughput

0.536

High

880960

MTR1B
Melatonin receptor type 1B

1

1

High-throughput

0.494

High

213698

AQP9
Aquaporin-9

1

3

High-throughput

0.489

High

990708

1433Z
14-3-3 protein zeta/delta

1

1

High-throughput

0.489

High

1417870

DUS16
Dual specificity protein phosphatase 16

1

1

High-throughput

0.489

High

508589

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.480

High

126787

RHOD
Rho-related GTP-binding protein RhoD

1

7

High-throughput

0.479

High

581275

RAC2
Ras-related C3 botulinum toxin substrate 2

1

6

High-throughput

0.479

High

691413

1433T
14-3-3 protein theta

1

1

Small-scale

0.479

High

955565

CDC42
Cell division control protein 42 homolog

1

6

High-throughput

0.479

High

1312246

MIRO2
Mitochondrial Rho GTPase 2

1

8

High-throughput

0.479

High

63698

A5PKU2
TUSC5 protein

1

1

High-throughput

0.470

High

1232567

Q6FHY5
MEOX2 protein

1

1

High-throughput

0.470

High

1242383

Q6P4D7
TM6SF1 protein

1

1

High-throughput

0.470

High

718730

FCERG
High affinity immunoglobulin epsilon receptor subunit gamma

1

0

High-throughput

0.460

High

106622

APRIO
Alternative prion protein

1

0

High-throughput

0.458

High

124481

HAX1
HCLS1-associated protein X-1

1

0

High-throughput

0.458

High

129407

MEN1
Menin

1

0

High-throughput

0.458

High

133794

PDE2A
cGMP-dependent 3',5'-cyclic phosphodiesterase

1

0

High-throughput

0.458

High

166999

MGST3
Glutathione S-transferase 3, mitochondrial

1

0

High-throughput

0.458

High

216809

HTRA2
Serine protease HTRA2, mitochondrial

1

0

High-throughput

0.458

High

281659

MTX2
Metaxin-2

1

0

High-throughput

0.458

High

348720

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

0

High-throughput

0.458

High

611334

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

0

High-throughput

0.458

High

901552

RAB7A
Ras-related protein Rab-7a

1

0

High-throughput

0.458

High

941968

PEX3
Peroxisomal biogenesis factor 3

1

0

High-throughput

0.458

High

1108130

SQSTM
Sequestosome-1

1

0

High-throughput

0.458

High

1125646

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

0

High-throughput

0.458

High

1147677

TOM20
Mitochondrial import receptor subunit TOM20 homolog

1

0

High-throughput

0.458

High

1161213

MK06
Mitogen-activated protein kinase 6

1

0

High-throughput

0.458

High

1278099

MAVS
Mitochondrial antiviral-signaling protein

1

0

High-throughput

0.458

High

1290965

TAXB1
Tax1-binding protein 1

1

0

High-throughput

0.458

High

1331247

ARL10
ADP-ribosylation factor-like protein 10

1

0

High-throughput

0.458

High

1366556

AKAP1
A-kinase anchor protein 1, mitochondrial

1

0

High-throughput

0.458

High

1394051

COX14
Cytochrome c oxidase assembly protein COX14

1

0

High-throughput

0.458

High

1403778

RMD3
Regulator of microtubule dynamics protein 3

1

0

High-throughput

0.458

High

1429131

PXMP2
Peroxisomal membrane protein 2

1

0

High-throughput

0.458

High

1429134

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

0

High-throughput

0.458

High

1429138

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

0

High-throughput

0.458

High

1429140

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.458

High

1429153

FIS1
Mitochondrial fission 1 protein

1

0

High-throughput

0.458

High

1429154

PTH2
Peptidyl-tRNA hydrolase 2, mitochondrial

1

0

High-throughput

0.458

High

894151

MEOX2
Homeobox protein MOX-2

1

1

High-throughput

0.439

High

1312126

TARG1
Trafficking regulator of GLUT4 1

1

1

High-throughput

0.439

High

1420303

TM6S1
Transmembrane 6 superfamily member 1

1

1

High-throughput

0.439

High

466447

RHOC
Rho-related GTP-binding protein RhoC

1

6

High-throughput

0.437

High

910187

RND2
Rho-related GTP-binding protein RhoN

1

7

High-throughput

0.437

High

953660

RAC3
Ras-related C3 botulinum toxin substrate 3

1

6

High-throughput

0.437

High

962456

RHOA
Transforming protein RhoA

1

7

High-throughput

0.437

High

988687

RAC1
Ras-related C3 botulinum toxin substrate 1

1

6

High-throughput

0.437

High

1015760

RHOG
Rho-related GTP-binding protein RhoG

1

6

High-throughput

0.437

High

1151861

RHOH
Rho-related GTP-binding protein RhoH

1

7

High-throughput

0.437

High

1429132

DUS22
Dual specificity protein phosphatase 22

1

1

High-throughput

0.437

High

1337946

ZNT7
Zinc transporter 7

1

0

High-throughput

0.426

High

60606

TM218
Transmembrane protein 218

2

0

High-throughput

0.316

High

160330

GOSR2
Golgi SNAP receptor complex member 2

2

0

High-throughput

0.316

High

162275

CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase

2

0

High-throughput

0.316

High

220417

LAT
Linker for activation of T-cells family member 1

2

0

High-throughput

0.316

High

278557

VAMP4
Vesicle-associated membrane protein 4

2

0

High-throughput

0.316

High

281481

MSPD3
Motile sperm domain-containing protein 3

2

0

High-throughput

0.316

High

292499

RHBL1
Rhomboid-related protein 1

2

0

High-throughput

0.316

High

327440

ZFPL1
Zinc finger protein-like 1

2

0

High-throughput

0.316

High

333514

MPZL1
Myelin protein zero-like protein 1

2

0

High-throughput

0.316

High

336172

CNIH1
Protein cornichon homolog 1

2

0

High-throughput

0.316

High

423843

APOD
Apolipoprotein D

2

0

High-throughput

0.316

High

464717

CXB1
Gap junction beta-1 protein

2

0

High-throughput

0.316

High

549882

CD79A
B-cell antigen receptor complex-associated protein alpha chain

2

0

High-throughput

0.316

High

666021

IBP5
Insulin-like growth factor-binding protein 5

2

0

High-throughput

0.316

High

712126

CO4A5

2

0

High-throughput

0.316

High

723714

NEUT
Neurotensin/neuromedin N [Cleaved into: Large neuromedin N

2

0

High-throughput

0.316

High

770916

OPRM
Mu-type opioid receptor

2

0

High-throughput

0.316

High

949294

MYPR
Myelin proteolipid protein

2

0

High-throughput

0.316

High

1007453

S35B1
Solute carrier family 35 member B1

2

0

High-throughput

0.316

High

1148940

SC23A
Protein transport protein Sec23A

2

0

High-throughput

0.316

High

1158845

VACHT
Vesicular acetylcholine transporter

2

0

High-throughput

0.316

High

1187419

SHSL1
Protein shisa-like-1

2

0

High-throughput

0.316

High

1195548

CTXN3
Cortexin-3

2

0

High-throughput

0.316

High

1200109

UNC50
Protein unc-50 homolog

2

0

High-throughput

0.316

High

1203135

SGMR2
Sigma intracellular receptor 2

2

0

High-throughput

0.316

High

1203345

TM128
Transmembrane protein 128

2

0

High-throughput

0.316

High

1203791

TTMP
TPA-induced transmembrane protein

2

0

High-throughput

0.316

High

1207612

F209A
Protein FAM209A

2

0

High-throughput

0.316

High

1210000

TM201
Transmembrane protein 201

2

0

High-throughput

0.316

High

1219265

ULBP6
UL16-binding protein 6

2

0

High-throughput

0.316

High

1229453

TMM42
Transmembrane protein 42

2

0

High-throughput

0.316

High

1242222

NPAL3
NIPA-like protein 3

2

0

High-throughput

0.316

High

1244112

TMM88
Transmembrane protein 88

2

0

High-throughput

0.316

High

1288416

TSN33
Tetraspanin-33

2

0

High-throughput

0.316

High

1292137

ANR46
Ankyrin repeat domain-containing protein 46

2

0

High-throughput

0.316

High

1312817

NRM
Nurim

2

0

High-throughput

0.316

High

1322554

CEND
Cell cycle exit and neuronal differentiation protein 1

2

0

High-throughput

0.316

High

1326897

EMC5
ER membrane protein complex subunit 5

2

0

High-throughput

0.316

High

1328197

JAGN1
Protein jagunal homolog 1

2

0

High-throughput

0.316

High

1328719

TR1L1
Translocating chain-associated membrane protein 1-like 1

2

0

High-throughput

0.316

High

1328807

TM86B
Lysoplasmalogenase TMEM86B

2

0

High-throughput

0.316

High

1329248

CLD19
Claudin-19

2

0

High-throughput

0.316

High

1331502

NRAC
Nutritionally-regulated adipose and cardiac enriched protein homolog

2

0

High-throughput

0.316

High

1333269

T229B
Transmembrane protein 229B

2

0

High-throughput

0.316

High

1339509

FDSCP
Follicular dendritic cell secreted peptide

2

0

High-throughput

0.316

High

1347197

LHPL5
LHFPL tetraspan subfamily member 5 protein

2

0

High-throughput

0.316

High

1349016

TM254
Transmembrane protein 254

2

0

High-throughput

0.316

High

1363561

FAM3C
Protein FAM3C

2

0

High-throughput

0.316

High

1388183

CKLF5
CKLF-like MARVEL transmembrane domain-containing protein 5

2

0

High-throughput

0.316

High

1395560

S41A2
Solute carrier family 41 member 2

2

0

High-throughput

0.316

High

1400543

TM237
Transmembrane protein 237

2

0

High-throughput

0.316

High

1404141

VATO
V-type proton ATPase 21 kDa proteolipid subunit c''

2

0

High-throughput

0.316

High

1410433

CYBC1
Cytochrome b-245 chaperone 1

2

0

High-throughput

0.316

High

1410670

APOL2
Apolipoprotein L2

2

0

High-throughput

0.316

High

1417773

SC11C
Signal peptidase complex catalytic subunit SEC11C

2

0

High-throughput

0.316

High

1429126

FXYD6
FXYD domain-containing ion transport regulator 6

2

0

High-throughput

0.316

High

1429127

UN93B
Protein unc-93 homolog B1

2

0

High-throughput

0.316

High

1429129

TMM60
Transmembrane protein 60

2

0

High-throughput

0.316

High

1429130

PLK3
Serine/threonine-protein kinase PLK3

2

0

High-throughput

0.316

High

1429135

GKN1
Gastrokine-1

2

0

High-throughput

0.316

High

1429136

SAC1
Phosphatidylinositol-3-phosphatase SAC1

2

0

High-throughput

0.316

High

1429137

TM140
Transmembrane protein 140

2

0

High-throughput

0.316

High

1429139

AIG1
Androgen-induced gene 1 protein

2

0

High-throughput

0.316

High

1429149

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

2

0

High-throughput

0.316

High

1429152

PLLP
Plasmolipin

2

0

High-throughput

0.316

High

1429157

TX264
Testis-expressed protein 264

2

0

High-throughput

0.316

High

1419407

ACTBM
Putative beta-actin-like protein 3

2

0

High-throughput

0.288

High

66457

ASB14
Ankyrin repeat and SOCS box protein 14

1

0

High-throughput

0.279

Low

220198

TNF14
Tumor necrosis factor ligand superfamily member 14

1

0

High-throughput

0.279

Low

347308

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.279

Low

1386573

OPTN
Optineurin

1

0

High-throughput

0.269

Low

516279

DWORF
Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF

1

0

High-throughput

0.268

Low

1402492

SERC2
Serine incorporator 2

1

0

High-throughput

0.251

Low

1429128

CXL16
C-X-C motif chemokine 16

1

0

High-throughput

0.251

Low

138310

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

0

High-throughput

0.249

Low

141953

PODXL
Podocalyxin

1

0

Small-scale

0.249

Low

589636

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

696450

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

769125

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

1255456

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1360818

ASB11
Ankyrin repeat and SOCS box protein 11

1

0

High-throughput

0.249

Low

1396805

SNX27
Sorting nexin-27

1

0

High-throughput

0.249

Low

1429145

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

231635

PRKY
Putative serine/threonine-protein kinase PRKY

1

0

High-throughput

0.232

Low

255208

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.232

Low

845126

EAA3
Excitatory amino acid transporter 3

1

0

High-throughput

0.232

Low

1236308

MFSD5
Molybdate-anion transporter

1

0

High-throughput

0.232

Low

1242925

S39A4
Zinc transporter ZIP4

1

0

High-throughput

0.232

Low

1308964

S22A9
Organic anion transporter 7

1

0

High-throughput

0.232

Low

1429150

ITM2B
Integral membrane protein 2B

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025