Protein: GBA2
Non-lysosomal glucosylceramidase (NLGase) (EC 3.2.1.45) (Beta-glucocerebrosidase 2) (Beta-glucosidase 2) (Bile acid beta-glucosidase GBA2) (Bile acid glucosyl transferase GBA2) (Cholesterol glucosyltransferase GBA2) (EC 2.4.1.-) (Cholesteryl-beta-glucosidase GBA2) (EC 3.2.1.-) (Glucosylceramidase 2) (Non-lysosomal cholesterol glycosyltransferase) (Non-lysosomal galactosylceramidase) (EC 3.2.1.46) (Non-lysosomal glycosylceramidase)

Gene: GBA2
Organism: Homo sapiens
Interactions: 41
UniProt ID: Q9HCG7

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0004336 - galactosylceramidase activity
GO:0004348 - glucosylceramidase activity
GO:0005789 - endoplasmic reticulum membrane
GO:0005790 - smooth endoplasmic reticulum

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

50702

HACL2
2-hydroxyacyl-CoA lyase 2

4

0

High-throughput

0.667

High

219234

LTOR5
Ragulator complex protein LAMTOR5

1

0

High-throughput

0.513

High

286789

SKAP2
Src kinase-associated phosphoprotein 2

1

0

High-throughput

0.513

High

596780

DPEP1
Dipeptidase 1

1

0

High-throughput

0.513

High

1095593

LIPA1
Liprin-alpha-1

1

0

High-throughput

0.513

High

1257768

VP13C
Intermembrane lipid transfer protein VPS13C

1

0

High-throughput

0.513

High

1437096

RM44
Large ribosomal subunit protein mL44

1

0

High-throughput

0.513

High

1439037

SRP68
Signal recognition particle subunit SRP68

1

0

High-throughput

0.513

High

1439039

BAG5
BAG family molecular chaperone regulator 5

1

0

High-throughput

0.513

High

869793

MTR1A
Melatonin receptor type 1A

1

0

High-throughput

0.486

High

423222

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

1334009

DHB11
Estradiol 17-beta-dehydrogenase 11

1

1

High-throughput

0.479

High

174102

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

0

High-throughput

0.458

High

895075

EMD
Emerin

1

0

High-throughput

0.458

High

951444

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.458

High

1414459

DERL1
Derlin-1

1

0

High-throughput

0.458

High

1436317

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.458

High

1439036

TM216
Transmembrane protein 216

1

0

High-throughput

0.458

High

722626

CTR1
High affinity cationic amino acid transporter 1

1

2

High-throughput

0.445

High

869676

SC6A8
Sodium- and chloride-dependent creatine transporter 1

1

1

High-throughput

0.445

High

870420

S6A11
Sodium- and chloride-dependent GABA transporter 3

1

1

High-throughput

0.445

High

1242940

S39A4
Zinc transporter ZIP4

1

1

High-throughput

0.445

High

1361313

CTR3
Cationic amino acid transporter 3

1

2

High-throughput

0.445

High

1421355

S39A8
Metal cation symporter ZIP8

1

1

High-throughput

0.445

High

1439038

LAT2
Large neutral amino acids transporter small subunit 2

1

2

High-throughput

0.445

High

469446

ELNE
Neutrophil elastase

1

0

Small-scale

0.438

High

1011190

RT22
Small ribosomal subunit protein mS22

1

1

High-throughput

0.437

High

67089

S38A8
Solute carrier family 38 member 8

1

0

High-throughput

0.426

High

653582

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.426

High

1242233

NPAL3
NIPA-like protein 3

1

0

High-throughput

0.426

High

1312989

S35F2
Solute carrier family 35 member F2

1

0

High-throughput

0.426

High

1337963

ZNT7
Zinc transporter 7

1

0

High-throughput

0.426

High

1389481

NTCP4
Sodium/bile acid cotransporter 4

1

0

High-throughput

0.426

High

1389668

MFSD3
Major facilitator superfamily domain-containing protein 3

1

0

High-throughput

0.426

High

109573

G5E9W7
Mitochondrial ribosomal protein S22

1

1

High-throughput

0.407

High

1333817

RDH13
Retinol dehydrogenase 13

1

0

High-throughput

0.279

Low

1439040

AFG32
Mitochondrial inner membrane m-AAA protease component AFG3L2

1

0

High-throughput

0.279

Low

551274

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.249

Low

613189

EGR1
Early growth response protein 1

1

0

High-throughput

0.249

Low

1255628

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1439035

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025