Protein: BHE40
Class E basic helix-loop-helix protein 40 (bHLHe40) (Class B basic helix-loop-helix protein 2) (bHLHb2) (Differentially expressed in chondrocytes protein 1) (DEC1) (Enhancer-of-split and hairy-related protein 2) (SHARP-2) (Stimulated by retinoic acid gene 13 protein)

Gene: BHE40, BHLHE40
Organism: Homo sapiens
Interactions: 135
UniProt ID: O14503

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

146434

BHE40
Class E basic helix-loop-helix protein 40

2

19

High-throughput

0.785

High

146497

LASP1
LIM and SH3 domain protein 1

2

1

High-throughput

0.783

High

146525

LMO3
LIM domain only protein 3

2

4

High-throughput

0.783

High

146451

TFE2
Transcription factor E2-alpha

1

8

Small-scale

0.713

High

146559

FBW1A
F-box/WD repeat-containing protein 1A

4

7

Small-scale

0.703

High

146441

RHBT3
Rho-related BTB domain-containing protein 3

4

4

High-throughput

0.698

High

146523

SMYD1
Histone-lysine N-methyltransferase SMYD1

5

0

High-throughput

0.691

High

146485

TLE5
TLE family member 5

3

20

High-throughput

0.675

High

146561

MAGD1
Melanoma-associated antigen D1

3

2

High-throughput

0.675

High

146554

FBW1B
F-box/WD repeat-containing protein 11

3

7

Small-scale

0.674

High

146550

RFOX1
RNA binding protein fox-1 homolog 1

3

4

High-throughput

0.654

High

146449

MYOD1
Myoblast determination protein 1

1

13

Small-scale

0.647

High

146543

NAA50
N-alpha-acetyltransferase 50

3

0

High-throughput

0.646

High

146445

P53
Cellular tumor antigen p53

2

2

Small-scale

0.628

High

146505

SNAT
Serotonin N-acetyltransferase

2

0

High-throughput

0.626

High

146542

BHE41
Class E basic helix-loop-helix protein 41

1

19

Small-scale

0.618

High

146444

VENTX
Homeobox protein VENTX

2

8

High-throughput

0.606

High

146468

ATX1
Ataxin-1

2

2

High-throughput

0.606

High

146479

PO6F2
POU domain, class 6, transcription factor 2

2

1

High-throughput

0.606

High

146499

DAZP2
DAZ-associated protein 2

2

1

High-throughput

0.606

High

146503

ZFHX3
Zinc finger homeobox protein 3

2

2

High-throughput

0.606

High

146514

RBPS2
RNA-binding protein with multiple splicing 2

2

3

High-throughput

0.606

High

146530

DVL3
Segment polarity protein dishevelled homolog DVL-3

2

3

High-throughput

0.606

High

146532

TET5B
Terminal nucleotidyltransferase 5B

2

2

High-throughput

0.606

High

146560

ARIP4
Helicase ARIP4

2

1

High-throughput

0.606

High

146492

HDAC1
Histone deacetylase 1

2

6

Small-scale

0.602

High

146455

RXRA
Retinoic acid receptor RXR-alpha

2

3

Small-scale

0.601

High

146540

NPAS2
Neuronal PAS domain-containing protein 2

1

7

High-throughput

0.590

High

146475

UBC9
SUMO-conjugating enzyme UBC9

1

2

Small-scale

0.586

High

146465

STK19
Inactive serine/threonine-protein kinase 19

2

1

High-throughput

0.584

High

146435

PHF1
PHD finger protein 1

2

0

High-throughput

0.580

High

146453

WT1
Wilms tumor protein

2

0

High-throughput

0.580

High

146484

CREM
cAMP-responsive element modulator

2

0

High-throughput

0.580

High

146494

BYST
Bystin

2

0

High-throughput

0.580

High

146518

FA83A
Protein FAM83A

2

0

High-throughput

0.580

High

146526

SMAP2
Stromal membrane-associated protein 2

2

0

High-throughput

0.580

High

146535

MCRS1
Microspherule protein 1

2

0

High-throughput

0.580

High

146539

PFD5
Prefoldin subunit 5

2

0

High-throughput

0.580

High

146548

NEK6
Serine/threonine-protein kinase Nek6

2

0

High-throughput

0.580

High

146437

SOX15
Transcription factor SOX-15

1

1

High-throughput

0.573

High

146438

DAB1
Disabled homolog 1

1

1

High-throughput

0.573

High

146491

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

1

High-throughput

0.573

High

146517

RBM23
Probable RNA-binding protein 23

1

1

High-throughput

0.573

High

146531

RBPMS
RNA-binding protein with multiple splicing

1

3

High-throughput

0.573

High

146493

AAMP
Angio-associated migratory cell protein

2

3

High-throughput

0.559

High

146450

ZEP1
Zinc finger protein 40

2

0

High-throughput

0.559

High

81903

B7ZLI8
Serine/threonine kinase 19

2

1

High-throughput

0.558

High

146442

MTCL2
Microtubule cross-linking factor 2

2

3

High-throughput

0.553

High

146483

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

2

2

High-throughput

0.553

High

146507

KRA61
Keratin-associated protein 6-1

2

3

High-throughput

0.553

High

146508

KRA62
Keratin-associated protein 6-2

2

5

High-throughput

0.553

High

146521

KRA81
Keratin-associated protein 8-1

2

1

High-throughput

0.553

High

146522

KRA13
Keratin-associated protein 1-3

2

4

High-throughput

0.553

High

146440

CCNK
Cyclin-K

1

0

High-throughput

0.549

High

146495

TOB2
Protein Tob2

1

0

High-throughput

0.549

High

146446

ENOA
Alpha-enolase

1

1

High-throughput

0.541

High

146447

VIME
Vimentin

1

1

High-throughput

0.541

High

146488

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

1

High-throughput

0.541

High

146500

SETB1
Histone-lysine N-methyltransferase SETDB1

1

1

High-throughput

0.541

High

146549

BRD7
Bromodomain-containing protein 7

1

4

High-throughput

0.541

High

146555

ZHX1
Zinc fingers and homeoboxes protein 1

1

1

High-throughput

0.541

High

146474

SKP1
S-phase kinase-associated protein 1

1

2

High-throughput

0.536

High

146516

LARP4
La-related protein 4

1

1

High-throughput

0.523

High

146534

PKHB2
Pleckstrin homology domain-containing family B member 2

1

2

High-throughput

0.523

High

146546

RHOJ
Rho-related GTP-binding protein RhoJ

1

9

High-throughput

0.523

High

146466

FXR1
RNA-binding protein FXR1

1

0

High-throughput

0.518

High

146469

RBM11
Splicing regulator RBM11

1

0

High-throughput

0.518

High

146489

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

0

High-throughput

0.518

High

146544

TOLIP
Toll-interacting protein

1

0

High-throughput

0.518

High

146538

SIN3A
Paired amphipathic helix protein Sin3a

1

1

Small-scale

0.501

High

146524

GMCL2
Germ cell-less protein-like 2

1

0

High-throughput

0.493

High

146527

HNRLL
Heterogeneous nuclear ribonucleoprotein L-like

1

2

High-throughput

0.481

High

146537

TET5A
Terminal nucleotidyltransferase 5A

1

2

High-throughput

0.481

High

146552

TBA8
Tubulin alpha-8 chain

1

6

High-throughput

0.481

High

146562

NUMBL
Numb-like protein

1

1

High-throughput

0.481

High

146443

SC31A
Protein transport protein Sec31A

1

3

Small-scale

0.479

High

146461

FUS
RNA-binding protein FUS

1

3

Small-scale

0.479

High

146463

STAT3
Signal transducer and activator of transcription 3

1

3

Small-scale

0.479

High

146464

GATA4
Transcription factor GATA-4

1

3

Small-scale

0.479

High

146472

H4
Histone H4

1

2

High-throughput

0.479

High

146473

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

2

Small-scale

0.479

High

146482

MDM2
E3 ubiquitin-protein ligase Mdm2

1

1

Small-scale

0.479

High

146490

TP53B
TP53-binding protein 1

1

1

High-throughput

0.479

High

146511

TAF3
Transcription initiation factor TFIID subunit 3

1

3

Small-scale

0.479

High

146547

EMAL4
Echinoderm microtubule-associated protein-like 4

1

2

Small-scale

0.479

High

146553

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

1

Small-scale

0.479

High

146557

PRP19
Pre-mRNA-processing factor 19

1

3

Small-scale

0.479

High

146558

COR2B
Coronin-2B

1

5

Small-scale

0.479

High

87388

C9JG97
Angio associated migratory cell protein

1

3

High-throughput

0.470

High

146480

PR20D
Proline-rich protein 20D

1

1

High-throughput

0.470

High

146458

PML
Protein PML

1

0

High-throughput

0.458

High

146529

RENT1
Regulator of nonsense transcripts 1

1

0

Small-scale

0.458

High

146454

CSK22
Casein kinase II subunit alpha'

1

12

High-throughput

0.457

High

146459

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

2

High-throughput

0.457

High

146460

2AAB
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

1

2

High-throughput

0.457

High

146462

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

5

High-throughput

0.457

High

146467

RORG
Nuclear receptor ROR-gamma

1

19

High-throughput

0.457

High

146470

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

5

High-throughput

0.457

High

146471

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

5

High-throughput

0.457

High

146476

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

4

High-throughput

0.457

High

146477

CSK2B
Casein kinase II subunit beta

1

4

High-throughput

0.457

High

146478

CSK21
Casein kinase II subunit alpha

1

14

High-throughput

0.457

High

146496

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

1

2

High-throughput

0.457

High

146498

NR1D2
Nuclear receptor subfamily 1 group D member 2

1

19

High-throughput

0.457

High

146501

NONO
Non-POU domain-containing octamer-binding protein

1

2

High-throughput

0.457

High

146504

2A5E
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform

1

2

High-throughput

0.457

High

146506

NFIL3
Nuclear factor interleukin-3-regulated protein

1

6

High-throughput

0.457

High

146528

RORB
Nuclear receptor ROR-beta

1

10

High-throughput

0.457

High

146545

FXL15
F-box/LRR-repeat protein 15

1

1

High-throughput

0.457

High

146563

X5D7T5
RNA binding protein fox-1 homolog

1

4

High-throughput

0.457

High

146564

X5DP44
RNA binding protein fox-1 homolog

1

4

High-throughput

0.457

High

146481

PR20A
Proline-rich protein 20A

1

1

High-throughput

0.439

High

146533

APH1A
Gamma-secretase subunit APH-1A

1

1

High-throughput

0.439

High

146502

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.438

High

146436

BUB3
Mitotic checkpoint protein BUB3

1

3

Small-scale

0.437

High

146556

COR1C
Coronin-1C

1

4

Small-scale

0.437

High

146487

VAC14
Protein VAC14 homolog

3

0

High-throughput

0.352

High

146448

COX5B
Cytochrome c oxidase subunit 5B, mitochondrial

2

0

High-throughput

0.327

High

146509

KR195
Keratin-associated protein 19-5

2

0

High-throughput

0.316

High

146510

KR197
Keratin-associated protein 19-7

2

0

High-throughput

0.316

High

146515

UBP54
Inactive ubiquitin carboxyl-terminal hydrolase 54

2

0

High-throughput

0.316

High

146519

GPSM1
G-protein-signaling modulator 1

2

0

High-throughput

0.316

High

146520

KR191
Keratin-associated protein 19-1

2

0

High-throughput

0.316

High

146536

KLD7B
Kelch domain-containing protein 7B

2

0

High-throughput

0.316

High

49698

KR231
Keratin-associated protein 23-1

1

0

High-throughput

0.299

High

146452

CNRG
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

1

0

High-throughput

0.299

High

146512

TTC23
Tetratricopeptide repeat protein 23

1

0

High-throughput

0.299

High

146513

CDPF1
Cysteine-rich DPF motif domain-containing protein 1

1

0

High-throughput

0.299

High

146541

NOC4L
Nucleolar complex protein 4 homolog

1

0

High-throughput

0.299

High

146551

TXN4B
Thioredoxin-like protein 4B

1

0

High-throughput

0.299

High

146456

FBLN1
Fibulin-1

1

0

High-throughput

0.282

High

146457

CALL3
Calmodulin-like protein 3

1

0

High-throughput

0.282

High

146486

ECHP
Peroxisomal bifunctional enzyme

1

0

High-throughput

0.268

Low

146439

NU155
Nuclear pore complex protein Nup155

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024