Protein: ELNE
Neutrophil elastase (EC 3.4.21.37) (Bone marrow serine protease) (Elastase-2) (Human leukocyte elastase) (HLE) (Medullasin) (PMN elastase)

Gene: ELNE, ELANE
Organism: Homo sapiens
Interactions: 69
UniProt ID: P08246

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0001878 - response to yeast
GO:0002020 - protease binding
GO:0002438 - acute inflammatory response to antigenic stimulus
GO:0002523 - leukocyte migration involved in inflammatory response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

369300

A1AT
Alpha-1-antitrypsin

3

20

Small-scale

0.834

High

469401

A2AP
Alpha-2-antiplasmin

2

20

Small-scale

0.778

High

469409

ITIH2
Inter-alpha-trypsin inhibitor heavy chain H2

2

5

High-throughput

0.776

High

469431

NT2NA
Notch homolog 2 N-terminal-like protein A

1

20

Small-scale

0.740

High

210687

KLK10
Kallikrein-10

1

18

High-throughput

0.691

High

469440

NEUS
Neuroserpin

1

20

High-throughput

0.691

High

369427

AACT
Alpha-1-antichymotrypsin

1

20

Small-scale

0.647

High

425209

IC1
Plasma protease C1 inhibitor

1

20

Small-scale

0.647

High

469414

ILEU
Leukocyte elastase inhibitor

1

20

Small-scale

0.647

High

469402

GRAB
Granzyme B

1

15

Small-scale

0.618

High

399398

SLPI
Antileukoproteinase

1

0

Small-scale

0.614

High

369589

A2MG
Alpha-2-macroglobulin

1

11

Small-scale

0.590

High

469410

CAP7
Azurocidin

1

16

Small-scale

0.590

High

469419

FCGRN
IgG receptor FcRn large subunit p51

1

14

Small-scale

0.590

High

469407

ELN
Elastin

2

14

Small-scale

0.584

High

369236

ANT3
Antithrombin-III

1

20

High-throughput

0.575

High

469442

EGFL8
Epidermal growth factor-like protein 8

1

20

High-throughput

0.575

High

469421

OCRL
Inositol polyphosphate 5-phosphatase OCRL

2

2

High-throughput

0.571

High

210166

IRAK2
Interleukin-1 receptor-associated kinase-like 2

1

2

High-throughput

0.536

High

469433

RHBL4
Rhomboid-related protein 4

1

5

High-throughput

0.536

High

469435

MIB2
E3 ubiquitin-protein ligase MIB2

1

1

High-throughput

0.536

High

469439

SRPK1
SRSF protein kinase 1

1

1

High-throughput

0.536

High

469445

FKRP
Ribitol 5-phosphate transferase FKRP

1

0

High-throughput

0.513

High

370397

KNG1
Kininogen-1

1

5

Small-scale

0.501

High

464400

TSP1
Thrombospondin-1

1

20

Small-scale

0.501

High

469413

PROP
Properdin

1

18

Small-scale

0.501

High

469444

ACE2
Angiotensin-converting enzyme 2

1

3

Small-scale

0.501

High

469452

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

5

High-throughput

0.489

High

469408

CEBPB
CCAAT/enhancer-binding protein beta

1

8

Small-scale

0.479

High

469425

CEBPE
CCAAT/enhancer-binding protein epsilon

1

8

Small-scale

0.479

High

469436

DCPS
m7GpppX diphosphatase

1

1

High-throughput

0.479

High

469437

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

2

Small-scale

0.479

High

469448

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

5

High-throughput

0.479

High

469441

GFI1
Zinc finger protein Gfi-1

1

0

Small-scale

0.458

High

388601

C1QA
Complement C1q subcomponent subunit A

1

8

Small-scale

0.457

High

388760

C1QC
Complement C1q subcomponent subunit C

1

11

Small-scale

0.457

High

456176

CATD
Cathepsin D

1

2

Small-scale

0.457

High

469400

CO4A2

1

7

Small-scale

0.457

High

469405

CH60
60 kDa heat shock protein, mitochondrial

1

3

Small-scale

0.457

High

469406

MMP9
Matrix metalloproteinase-9

1

12

Small-scale

0.457

High

469418

ACLY
ATP-citrate synthase

1

3

Small-scale

0.457

High

469420

DCAF7
DDB1- and CUL4-associated factor 7

1

4

Small-scale

0.457

High

469422

TLE5
TLE family member 5

1

3

Small-scale

0.457

High

469423

CHIT1
Chitotriosidase-1

1

2

Small-scale

0.457

High

469432

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

4

Small-scale

0.457

High

469434

N42L2
NEDD4-binding protein 2-like 2

1

2

Small-scale

0.457

High

469447

WDR6
tRNA

1

6

Small-scale

0.457

High

469449

WRP73
WD repeat-containing protein WRAP73

1

3

Small-scale

0.457

High

469451

VPS29
Vacuolar protein sorting-associated protein 29

1

1

Small-scale

0.457

High

469415

SFTPD
Pulmonary surfactant-associated protein D

1

10

Small-scale

0.445

High

469417

CAMP
Cathelicidin antimicrobial peptide

1

3

Small-scale

0.445

High

469426

CCL14
C-C motif chemokine 14

1

1

Small-scale

0.445

High

469427

TR16L
Tripartite motif-containing protein 16-like protein

1

7

High-throughput

0.445

High

469428

KLH22
Kelch-like protein 22

1

4

High-throughput

0.445

High

469429

TGO1
Transport and Golgi organization protein 1 homolog

1

6

High-throughput

0.445

High

469430

A16L1
Autophagy-related protein 16-1

1

9

High-throughput

0.445

High

469450

CCG4
Voltage-dependent calcium channel gamma-4 subunit

1

1

High-throughput

0.445

High

438944

DCUP
Uroporphyrinogen decarboxylase

1

0

Small-scale

0.438

High

469424

GAMT
Guanidinoacetate N-methyltransferase

1

0

Small-scale

0.438

High

469446

GBA2
Non-lysosomal glucosylceramidase

1

0

Small-scale

0.438

High

469403

IL8
Interleukin-8

1

0

Small-scale

0.426

High

360362

COX2
Cytochrome c oxidase subunit 2

1

1

Small-scale

0.417

High

469411

COX5A
Cytochrome c oxidase subunit 5A, mitochondrial

1

1

Small-scale

0.417

High

469412

HEM0
5-aminolevulinate synthase, erythroid-specific, mitochondrial

1

7

Small-scale

0.417

High

469416

PIGA
Phosphatidylinositol N-acetylglucosaminyltransferase subunit A

1

2

Small-scale

0.417

High

469438

CI085
Uncharacterized protein C9orf85

1

3

High-throughput

0.407

High

469443

RSRP1
Arginine/serine-rich protein 1

1

4

High-throughput

0.407

High

360707

COX3
Cytochrome c oxidase subunit 3

1

0

Small-scale

0.238

Low

469404

COX5B
Cytochrome c oxidase subunit 5B, mitochondrial

1

0

Small-scale

0.238

Low


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Last updated: 11Aug2025