Protein: ESTD
S-formylglutathione hydrolase (FGH) (EC 3.1.2.12) (Esterase D) (Methylumbelliferyl-acetate deacetylase) (EC 3.1.1.56)

Gene: ESTD, ESD
Organism: Homo sapiens
Interactions: 55
UniProt ID: P10768

Gene Ontology (top 5):
GO:0005788 - endoplasmic reticulum lumen
GO:0005829 - cytosol
GO:0016788 - hydrolase activity, acting on ester bonds
GO:0018738 - S-formylglutathione hydrolase activity
GO:0031410 - cytoplasmic vesicle

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

532202

ESTD
S-formylglutathione hydrolase

4

2

High-throughput

0.893

High

51394

FSD2
Fibronectin type III and SPRY domain-containing protein 2

6

1

High-throughput

0.671

High

408635

G3P
Glyceraldehyde-3-phosphate dehydrogenase

2

0

High-throughput

0.585

High

532213

CRK
Adapter molecule crk

2

2

High-throughput

0.576

High

532206

PLCG2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

2

0

High-throughput

0.551

High

532218

CAV1
Caveolin-1

2

0

High-throughput

0.547

High

532215

ARP2
Actin-related protein 2

1

1

High-throughput

0.536

High

532224

MYLK
Myosin light chain kinase, smooth muscle

1

1

High-throughput

0.536

High

213783

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

0

High-throughput

0.513

High

258544

DIAP2
Protein diaphanous homolog 2

1

0

High-throughput

0.513

High

532212

LONM
Lon protease homolog, mitochondrial

1

0

High-throughput

0.513

High

532221

HDAC1
Histone deacetylase 1

1

0

High-throughput

0.513

High

532223

DCTN1
Dynactin subunit 1

1

0

High-throughput

0.513

High

532235

KPCD2
Serine/threonine-protein kinase D2

1

0

High-throughput

0.513

High

532238

MBNL1
Muscleblind-like protein 1

1

0

High-throughput

0.513

High

532242

SAR1B
Small COPII coat GTPase SAR1B

1

0

High-throughput

0.513

High

532229

MYLK4
Myosin light chain kinase family member 4

1

1

High-throughput

0.489

High

532216

GRB2
Growth factor receptor-bound protein 2

1

0

High-throughput

0.486

High

240577

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

532225

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

High-throughput

0.479

High

532240

FYV1
1-phosphatidylinositol 3-phosphate 5-kinase

1

1

High-throughput

0.479

High

379842

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.458

High

388952

FINC
Fibronectin

1

0

High-throughput

0.458

High

519686

ANDR
Androgen receptor

1

0

High-throughput

0.458

High

532209

CRCM
Colorectal mutant cancer protein

1

0

High-throughput

0.458

High

532217

ACTC
Actin, alpha cardiac muscle 1

1

0

High-throughput

0.458

High

532220

SRSF5
Serine/arginine-rich splicing factor 5

1

0

High-throughput

0.458

High

532228

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

532231

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

532234

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

532236

ATG5
Autophagy protein 5

1

0

High-throughput

0.458

High

532239

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

532241

TRAF6
TNF receptor-associated factor 6

1

0

High-throughput

0.458

High

532214

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.445

High

532226

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

532237

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.437

High

532208

VCAM1
Vascular cell adhesion protein 1

1

0

High-throughput

0.426

High

532232

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.426

High

96863

E9PDH4
Phosphoinositide kinase, FYVE-type zinc finger containing

1

1

High-throughput

0.407

High

328221

NDUA3
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3

1

0

High-throughput

0.279

Low

532203

ACADM
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

532204

QCR7
Cytochrome b-c1 complex subunit 7

1

0

High-throughput

0.279

Low

532219

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

0

High-throughput

0.279

Low

532227

HEAT3
HEAT repeat-containing protein 3

1

0

High-throughput

0.279

Low

532230

CDKL3
Cyclin-dependent kinase-like 3

1

0

High-throughput

0.279

Low

532233

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.279

Low

259349

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.249

Low

352887

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low

411249

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

532205

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

532207

NELFE
Negative elongation factor E

1

0

High-throughput

0.249

Low

532210

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

532211

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

532222

NOG2
Nucleolar GTP-binding protein 2

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025