Protein: MYLK4
Myosin light chain kinase family member 4 (EC 2.7.11.1) (Sugen kinase 85) (SgK085)

Gene: MYLK4
Organism: Homo sapiens
Interactions: 90
UniProt ID: Q86YV6

Gene Ontology (top 5):
GO:0004687 - myosin light chain kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0007165 - signal transduction
GO:0106310 - protein serine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

461672

HS90A
Heat shock protein HSP 90-alpha

5

20

High-throughput

0.927

High

468565

HS90B
Heat shock protein HSP 90-beta

5

20

High-throughput

0.927

High

1158412

CDC37
Hsp90 co-chaperone Cdc37

2

8

High-throughput

0.754

High

1201987

H90B4
Putative heat shock protein HSP 90-beta 4

2

20

High-throughput

0.712

High

1202055

HS905
Putative heat shock protein HSP 90-alpha A5

2

20

High-throughput

0.712

High

573560

ENPL
Endoplasmin

1

20

High-throughput

0.691

High

1038659

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

17

High-throughput

0.691

High

1090456

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

4

High-throughput

0.691

High

1160196

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

7

High-throughput

0.691

High

931680

RD23B
UV excision repair protein RAD23 homolog B

1

13

High-throughput

0.618

High

959354

RAP1B
Ras-related protein Rap-1b

1

8

High-throughput

0.618

High

1026896

FKBP3
Peptidyl-prolyl cis-trans isomerase FKBP3

1

11

High-throughput

0.618

High

1295641

RAB21
Ras-related protein Rab-21

1

6

High-throughput

0.618

High

1295632

UBCP1
Ubiquitin-like domain-containing CTD phosphatase 1

1

0

High-throughput

0.578

High

1202022

H90B3
Putative heat shock protein HSP 90-beta-3

1

20

High-throughput

0.575

High

365419

PGK1
Phosphoglycerate kinase 1

1

2

High-throughput

0.536

High

420602

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

4

High-throughput

0.536

High

451022

LDHB
L-lactate dehydrogenase B chain

1

7

High-throughput

0.536

High

547641

C1TC
C-1-tetrahydrofolate synthase, cytoplasmic

1

2

High-throughput

0.536

High

582866

EZRI
Ezrin

1

9

High-throughput

0.536

High

640943

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

2

High-throughput

0.536

High

646881

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

1

High-throughput

0.536

High

647596

UBA1
Ubiquitin-like modifier-activating enzyme 1

1

1

High-throughput

0.536

High

656177

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

2

High-throughput

0.536

High

683864

MOES
Moesin

1

9

High-throughput

0.536

High

687263

HMGB2
High mobility group protein B2

1

9

High-throughput

0.536

High

687691

SYTC
Threonine--tRNA ligase 1, cytoplasmic

1

2

High-throughput

0.536

High

697942

CALR
Calreticulin

1

4

High-throughput

0.536

High

715661

MARCS
Myristoylated alanine-rich C-kinase substrate

1

4

High-throughput

0.536

High

716314

PRDX6
Peroxiredoxin-6

1

1

High-throughput

0.536

High

717319

PEBP1
Phosphatidylethanolamine-binding protein 1

1

2

High-throughput

0.536

High

724773

METK2
S-adenosylmethionine synthase isoform type-2

1

2

High-throughput

0.536

High

749959

KINH
Kinesin-1 heavy chain

1

1

High-throughput

0.536

High

755749

MCM4
DNA replication licensing factor MCM4

1

3

High-throughput

0.536

High

756258

MCM7
DNA replication licensing factor MCM7

1

3

High-throughput

0.536

High

760960

GLYM
Serine hydroxymethyltransferase, mitochondrial

1

2

High-throughput

0.536

High

828665

MDHC
Malate dehydrogenase, cytoplasmic

1

7

High-throughput

0.536

High

828841

MDHM
Malate dehydrogenase, mitochondrial

1

5

High-throughput

0.536

High

837706

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

2

High-throughput

0.536

High

881070

NASP
Nuclear autoantigenic sperm protein

1

4

High-throughput

0.536

High

884667

SYHM
Histidine--tRNA ligase, mitochondrial

1

4

High-throughput

0.536

High

895931

F10A1
Hsc70-interacting protein

1

20

High-throughput

0.536

High

908418

HDGF
Hepatoma-derived growth factor

1

5

High-throughput

0.536

High

920844

ACLY
ATP-citrate synthase

1

3

High-throughput

0.536

High

932904

P5CS
Delta-1-pyrroline-5-carboxylate synthase

1

2

High-throughput

0.536

High

992607

IF5A1
Eukaryotic translation initiation factor 5A-1

1

1

High-throughput

0.536

High

992841

RACK1
Small ribosomal subunit protein RACK1

1

7

High-throughput

0.536

High

1010321

BASP1
Brain acid soluble protein 1

1

3

High-throughput

0.536

High

1144060

TEBP
Prostaglandin E synthase 3

1

3

High-throughput

0.536

High

1295634

CSN5
COP9 signalosome complex subunit 5

1

3

High-throughput

0.536

High

1295635

FUBP2
Far upstream element-binding protein 2

1

4

High-throughput

0.536

High

1295637

TBCB
Tubulin-folding cofactor B

1

12

High-throughput

0.536

High

1295642

PA2G4
Proliferation-associated protein 2G4

1

2

High-throughput

0.536

High

361294

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.513

High

878325

MRP
MARCKS-related protein

1

0

High-throughput

0.513

High

1030741

CAP1
Adenylyl cyclase-associated protein 1

1

0

High-throughput

0.513

High

1187003

TKFC
Triokinase/FMN cyclase

1

0

High-throughput

0.513

High

1295633

NDRG1
Protein NDRG1

1

0

High-throughput

0.513

High

1295638

PARK7
Parkinson disease protein 7

1

0

High-throughput

0.513

High

158844

AP3D1
AP-3 complex subunit delta-1

1

4

High-throughput

0.489

High

389746

FETUA
Alpha-2-HS-glycoprotein

1

2

High-throughput

0.489

High

481325

HMGB1
High mobility group protein B1

1

7

High-throughput

0.489

High

532229

ESTD
S-formylglutathione hydrolase

1

1

High-throughput

0.489

High

551143

PCNA
Proliferating cell nuclear antigen

1

1

High-throughput

0.489

High

566743

PDIA4
Protein disulfide-isomerase A4

1

9

High-throughput

0.489

High

571466

GLU2B
Glucosidase 2 subunit beta

1

4

High-throughput

0.489

High

698847

CALX
Calnexin

1

4

High-throughput

0.489

High

712234

TKT
Transketolase

1

5

High-throughput

0.489

High

717530

PDIA3
Protein disulfide-isomerase A3

1

8

High-throughput

0.489

High

767467

RADI
Radixin

1

9

High-throughput

0.489

High

882762

EFTU
Elongation factor Tu, mitochondrial

1

2

High-throughput

0.489

High

910319

6PGD
6-phosphogluconate dehydrogenase, decarboxylating

1

2

High-throughput

0.489

High

912582

GDIR1
Rho GDP-dissociation inhibitor 1

1

1

High-throughput

0.489

High

916178

BIEA
Biliverdin reductase A

1

2

High-throughput

0.489

High

941483

CTBP2
C-terminal-binding protein 2

1

5

High-throughput

0.489

High

1131306

GANAB
Neutral alpha-glucosidase AB

1

1

High-throughput

0.489

High

1142324

PDIA6
Protein disulfide-isomerase A6

1

9

High-throughput

0.489

High

1295630

TXND5
Thioredoxin domain-containing protein 5

1

9

High-throughput

0.489

High

1295640

RCC2
Protein RCC2

1

3

High-throughput

0.489

High

1035413

ODO1
2-oxoglutarate dehydrogenase complex component E1

1

3

High-throughput

0.470

High

1295631

SP20H
Transcription factor SPT20 homolog

2

0

High-throughput

0.318

High

295847

FACE1
CAAX prenyl protease 1 homolog

1

0

High-throughput

0.279

Low

329301

LETM1
Mitochondrial proton/calcium exchanger protein

1

0

High-throughput

0.279

Low

446439

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.279

Low

925946

TCP4
Activated RNA polymerase II transcriptional coactivator p15

1

0

High-throughput

0.279

Low

1295636

CLCC1
Chloride channel CLIC-like protein 1

1

0

High-throughput

0.279

Low

1295639

APMAP
Adipocyte plasma membrane-associated protein

1

0

High-throughput

0.279

Low

1295643

CNPY2
Protein canopy homolog 2

1

0

High-throughput

0.279

Low

1295644

LC7L2
Putative RNA-binding protein Luc7-like 2

1

0

High-throughput

0.279

Low

1295645

PAXB1
PAX3- and PAX7-binding protein 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025