Protein: FYV1
1-phosphatidylinositol 3-phosphate 5-kinase (Phosphatidylinositol 3-phosphate 5-kinase) (EC 2.7.1.150) (FYVE finger-containing phosphoinositide kinase) (PIKfyve) (Phosphatidylinositol 3-phosphate 5-kinase type III) (PIPkin-III) (Type III PIP kinase) (Serine-protein kinase PIKFYVE) (EC 2.7.11.1)

Gene: FYV1, PIKFYVE
Organism: Homo sapiens
Interactions: 46
UniProt ID: Q9Y2I7

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0000285 - 1-phosphatidylinositol-3-phosphate 5-kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1412056

WDR83
WD repeat domain-containing protein 83

4

20

High-throughput

0.881

High

1066044

VAC14
Protein VAC14 homolog

5

5

Small-scale

0.725

High

1364782

FIG4
Polyphosphoinositide phosphatase

5

4

Small-scale

0.712

High

1227738

A16L1
Autophagy-related protein 16-1

1

20

High-throughput

0.618

High

592956

ANK1
Ankyrin-1

2

2

High-throughput

0.611

High

1280185

RABEK
Rab9 effector protein with kelch motifs

1

12

Small-scale

0.586

High

423493

A4
Amyloid-beta precursor protein

2

0

Small-scale

0.577

High

447596

NPM
Nucleophosmin

1

1

High-throughput

0.515

High

998965

H31
Histone H3.1

1

6

Small-scale

0.512

High

1025529

CDK5
Cyclin-dependent kinase 5

1

18

Small-scale

0.501

High

412842

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.479

High

532240

ESTD
S-formylglutathione hydrolase

1

1

High-throughput

0.479

High

562500

LAMP2
Lysosome-associated membrane glycoprotein 2

1

1

High-throughput

0.479

High

631031

RAB4A
Ras-related protein Rab-4A

1

3

High-throughput

0.479

High

631577

RAB5A
Ras-related protein Rab-5A

1

3

High-throughput

0.479

High

832843

BCL6
B-cell lymphoma 6 protein

1

2

Small-scale

0.479

High

867535

CAPZB
F-actin-capping protein subunit beta

1

5

High-throughput

0.479

High

901691

RAB7A
Ras-related protein Rab-7a

1

2

High-throughput

0.479

High

902151

RAB9A
Ras-related protein Rab-9A

1

2

High-throughput

0.479

High

1026289

CLH1
Clathrin heavy chain 1

1

4

High-throughput

0.479

High

1156626

CCDC6
Coiled-coil domain-containing protein 6

1

9

High-throughput

0.479

High

1256167

TRI67
Tripartite motif-containing protein 67

1

16

High-throughput

0.479

High

1276377

ATG9A
Autophagy-related protein 9A

1

1

High-throughput

0.479

High

1383719

VP33A
Vacuolar protein sorting-associated protein 33A

1

2

High-throughput

0.479

High

1389428

RNF31
E3 ubiquitin-protein ligase RNF31

1

8

High-throughput

0.479

High

1438254

RHOF
Rho-related GTP-binding protein RhoF

1

2

High-throughput

0.479

High

1462781

LAMP3
Lysosome-associated membrane glycoprotein 3

1

1

High-throughput

0.479

High

1381654

GTPB3
5-taurinomethyluridine-[tRNA] synthase subunit GTPB3, mitochondrial

1

1

High-throughput

0.470

High

483268

CLCA
Clathrin light chain A

1

0

High-throughput

0.458

High

988841

RAC1
Ras-related C3 botulinum toxin substrate 1

1

0

High-throughput

0.458

High

1233592

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.458

High

1276993

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1363899

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

0

High-throughput

0.458

High

166456

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

1

2

High-throughput

0.445

High

1253185

NBEL2
Neurobeachin-like protein 2

1

20

High-throughput

0.445

High

1338020

ZNT7
Zinc transporter 7

1

2

High-throughput

0.445

High

168138

TIM23
Mitochondrial import inner membrane translocase subunit Tim23

1

1

High-throughput

0.437

High

218987

TGON2
Trans-Golgi network integral membrane protein 2

1

2

High-throughput

0.437

High

853439

CBX5
Chromobox protein homolog 5

1

9

Small-scale

0.437

High

1241990

FBX42
F-box only protein 42

1

12

High-throughput

0.437

High

405220

LCAT
Phosphatidylcholine-sterol acyltransferase

1

1

Small-scale

0.407

High

1490781

NPTN
Neuroplastin

1

0

High-throughput

0.279

Low

1116335

PTC1
Protein patched homolog 1

1

0

Small-scale

0.249

Low

1451758

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.249

Low

1010986

BAT1
b(0,+)-type amino acid transporter 1

1

0

High-throughput

0.232

Low

1395432

NEUL4
Neuralized-like protein 4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025