Protein: RPGF6
Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2)

Gene: RPGF6, RAPGEF6
Organism: Homo sapiens
Interactions: 74
UniProt ID: Q8TEU7

Gene Ontology (top 5):
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005813 - centrosome
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0007265 - Ras protein signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

170252

AURKA
Aurora kinase A

3

6

High-throughput

0.861

High

355093

APBA3
Amyloid-beta A4 precursor protein-binding family A member 3

3

3

High-throughput

0.855

High

375761

RASK
GTPase KRas

3

20

High-throughput

0.827

High

1090163

PTN13
Tyrosine-protein phosphatase non-receptor type 13

2

9

Small-scale

0.799

High

518616

RAP2A
Ras-related protein Rap-2a

2

20

Small-scale

0.799

High

374089

RASN
GTPase NRas

2

20

High-throughput

0.754

High

1353184

RPGF2
Rap guanine nucleotide exchange factor 2

1

3

High-throughput

0.665

High

862321

YAP1
Transcriptional coactivator YAP1

3

13

Small-scale

0.656

High

165129

RASM
Ras-related protein M-Ras

1

20

Small-scale

0.647

High

982107

RAP1A
Ras-related protein Rap-1A

1

20

Small-scale

0.647

High

966661

1433G
14-3-3 protein gamma

2

20

High-throughput

0.635

High

1049599

1433F
14-3-3 protein eta

2

20

High-throughput

0.635

High

730086

1433B
14-3-3 protein beta/alpha

2

20

High-throughput

0.628

High

971819

1433E
14-3-3 protein epsilon

2

3

High-throughput

0.628

High

64976

SWAHB
Ankyrin repeat domain-containing protein SOWAHB

1

5

High-throughput

0.618

High

374801

RASH
GTPase HRas

1

20

High-throughput

0.618

High

401195

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

10

High-throughput

0.618

High

710388

EPHA2
Ephrin type-A receptor 2

1

2

High-throughput

0.618

High

891259

GSK3A
Glycogen synthase kinase-3 alpha

1

3

High-throughput

0.618

High

891695

GSK3B
Glycogen synthase kinase-3 beta

1

4

High-throughput

0.618

High

978189

RHOB
Rho-related GTP-binding protein RhoB

1

11

High-throughput

0.618

High

1353169

PARD3
Partitioning defective 3 homolog

1

10

High-throughput

0.618

High

1353172

SNX27
Sorting nexin-27

1

13

High-throughput

0.618

High

1353180

ZO2
Tight junction protein 2

1

1

High-throughput

0.618

High

239153

ZNRD2
Protein ZNRD2

3

1

High-throughput

0.604

High

424530

PAI2
Plasminogen activator inhibitor 2

2

0

High-throughput

0.602

High

1353173

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

9

High-throughput

0.575

High

1254786

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.553

High

691274

1433T
14-3-3 protein theta

1

20

High-throughput

0.536

High

931020

HSP72
Heat shock-related 70 kDa protein 2

1

4

High-throughput

0.536

High

990534

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.536

High

347203

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.513

High

391379

FRIL
Ferritin light chain

1

0

High-throughput

0.513

High

705484

GRN
Progranulin

1

0

High-throughput

0.513

High

1353174

DUS16
Dual specificity protein phosphatase 16

1

0

High-throughput

0.513

High

861698

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

4

High-throughput

0.501

High

848686

MAGA9
Melanoma-associated antigen 9

1

1

High-throughput

0.489

High

173125

XPO1
Exportin-1

1

2

High-throughput

0.479

High

247393

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

2

High-throughput

0.479

High

537583

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

730787

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

831114

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

1045560

TF65
Transcription factor p65

1

1

High-throughput

0.479

High

1109930

HDAC1
Histone deacetylase 1

1

1

High-throughput

0.479

High

1157006

NTRK3
NT-3 growth factor receptor

1

5

High-throughput

0.479

High

1311636

KIBRA
Protein KIBRA

1

15

Small-scale

0.479

High

1331532

CE120
Centrosomal protein of 120 kDa

1

5

High-throughput

0.479

High

1353170

GOGA1
Golgin subfamily A member 1

1

4

High-throughput

0.479

High

1353175

WWTR1
WW domain-containing transcription regulator protein 1

1

13

High-throughput

0.479

High

1353176

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

4

Small-scale

0.479

High

1353177

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.479

High

1353181

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

1353183

ALK
ALK tyrosine kinase receptor

1

7

High-throughput

0.479

High

437283

K2C8
Keratin, type II cytoskeletal 8

1

0

High-throughput

0.458

High

459692

PROF1
Profilin-1

1

0

High-throughput

0.458

High

516771

SCHI1
Schwannomin-interacting protein 1

1

0

High-throughput

0.458

High

983902

RBX1
E3 ubiquitin-protein ligase RBX1

1

0

High-throughput

0.458

High

1041192

CAV1
Caveolin-1

1

0

High-throughput

0.458

High

1159770

OCLN
Occludin

1

0

High-throughput

0.458

High

1289479

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

535331

BIP
Endoplasmic reticulum chaperone BiP

1

2

High-throughput

0.445

High

246807

KDM1A
Lysine-specific histone demethylase 1A

1

1

High-throughput

0.437

High

589241

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.437

High

613108

EGR1
Early growth response protein 1

1

1

High-throughput

0.437

High

696026

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.437

High

768724

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

1096764

RFA4
Replication protein A 30 kDa subunit

1

2

High-throughput

0.437

High

1353171

PF21A
PHD finger protein 21A

1

2

High-throughput

0.437

High

1353179

SLTM
SAFB-like transcription modulator

1

5

High-throughput

0.437

High

58884

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

0

High-throughput

0.426

High

1353178

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.426

High

890255

TIG1
Retinoic acid receptor responder protein 1

1

0

High-throughput

0.279

Low

991888

DYLT1
Dynein light chain Tctex-type 1

1

0

High-throughput

0.249

Low

1353182

RCOR1
REST corepressor 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025