HitPredict

Interactor 1: RASM (O14807)
Ras-related protein M-Ras (EC 3.6.5.2) (Ras-related protein R-Ras3)
Gene: MRAS

Interactor 2: RPGF6 (Q8TEU7)
Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2)
Gene: RAPGEF6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	11524421
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PDZ~Ras, RA~Ras, Ras~RasGEF, Ras~RasGEF_N
Common GO terms	GO:0005886 - plasma membrane GO:0007265 - Ras protein signal transduction GO:0030742 - GTP-dependent protein binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 208 Hs			1 1601
+	Hs
		982107 RAP1A_HUMAN (14-180): 3.96e-57: 180: 53.57		RPGF6_HUMAN (1-1601): 0: 1379: 100.00
+	Hs
		165124 RASM_HUMAN (1-208): 3.14e-98: 285: 100.00		GNDS_HUMAN (832-1097): 7.91e-72: 262: 19.67
+	Hs
		1060692 RIT2_HUMAN (14-189): 2.79e-55: 176: 50.84		SOS1_HUMAN (650-1398): 4.01e-104: 366: 14.38
+	Dm
		473574 RAP1_DROME (14-175): 2.89e-57: 180: 54.32		Q9VMF3_DROME (640-1280): 2.84e-88: 320: 32.71
+	Hs
		967243 RRAS2_HUMAN (14-194): 8.45e-64: 197: 60.00		RGL1_HUMAN (697-1303): 1.64e-83: 293: 15.97
+	Hs
		959416 RAP1B_HUMAN (14-190): 1.57e-57: 181: 51.12		RGL1_HUMAN (697-1303): 1.64e-83: 293: 15.97
+	Hs
		982138 RAP1A_HUMAN (14-180): 3.96e-57: 180: 53.57		RGL1_HUMAN (697-1303): 1.64e-83: 293: 15.97
+	Hs
		967201 RRAS2_HUMAN (14-194): 8.45e-64: 197: 60.00		GNDS_HUMAN (832-1097): 7.91e-72: 262: 19.67
+	Hs
		982077 RAP1A_HUMAN (14-180): 3.96e-57: 180: 53.57		RPGF1_HUMAN (587-1112): 7.26e-74: 271: 17.36
+	Hs
		959321 RAP1B_HUMAN (14-190): 1.57e-57: 181: 51.12		GNDS_HUMAN (832-1097): 7.91e-72: 262: 19.67
+	Hs
		982070 RAP1A_HUMAN (14-180): 3.96e-57: 180: 53.57		GNDS_HUMAN (832-1097): 7.91e-72: 262: 19.67
+	Sc
		376172 RAS1_YEAST (14-176): 1.24e-54: 177: 58.90		CDC25_YEAST (707-1137): 5.13e-70: 262: 16.95
+	Hs
		1091741 RIT2_HUMAN (14-189): 2.79e-55: 176: 50.84		GNDS_HUMAN (832-1097): 7.91e-72: 262: 19.67
+	Hs
		165131 RASM_HUMAN (1-208): 3.14e-98: 285: 100.00		RPGF5_HUMAN (413-508): 3.57e-18: 92.5: 22.12
+	Hs
		335726 RAP1B_HUMAN (14-190): 1.57e-57: 181: 51.12		RPGF3_HUMAN (6-145): 3.45e-39: 161: 24.50
+	Hs
		335728 RAP1A_HUMAN (14-180): 3.96e-57: 180: 53.57		RPGF3_HUMAN (6-145): 3.45e-39: 161: 24.50
+	Ce
		1165926 RAP1_CAEEL (11-208): 3.52e-85: 251: 46.47		Q19770_CAEEL (854-1080): 7.1e-13: 75.5: 26.41
+	Hs
		982111 RAP1A_HUMAN (14-180): 3.96e-57: 180: 53.57		RPGF5_HUMAN (413-508): 3.57e-18: 92.5: 22.12
+	Hs
		982110 RAP1A_HUMAN (14-180): 3.96e-57: 180: 53.57		RPGF4_HUMAN (255-376): 1.45e-12: 75.1: 22.48
+	Hs
		982144 RAP1A_HUMAN (14-180): 3.96e-57: 180: 53.57		RPGF2_HUMAN (9-152): 1.08e-10: 69: 17.65