Protein: ERCC1
DNA excision repair protein ERCC-1

Gene: ERCC1
Organism: Homo sapiens
Interactions: 57
UniProt ID: P07992

Gene Ontology (top 5):
GO:0000109 - nucleotide-excision repair complex
GO:0000110 - nucleotide-excision repair factor 1 complex
GO:0000720 - pyrimidine dimer repair by nucleotide-excision repair
GO:0000781 - chromosome, telomeric region
GO:0001094 - TFIID-class transcription factor complex binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

464387

XPF
DNA repair endonuclease XPF

28

4

Small-scale

0.993

High

464390

MUS81
Structure-specific endonuclease subunit MUS81

3

0

Small-scale

0.796

High

464358

XPA
DNA repair protein complementing XP-A cells

19

2

Small-scale

0.766

High

464384

SLX4
Structure-specific endonuclease subunit SLX4

15

2

Small-scale

0.761

High

464391

UBL7
Ubiquitin-like protein 7

3

0

High-throughput

0.661

High

464394

SLX1
Structure-specific endonuclease subunit SLX1

3

0

Small-scale

0.642

High

464383

UBP45
Ubiquitin carboxyl-terminal hydrolase 45

2

1

Small-scale

0.633

High

464353

ERCC1
DNA excision repair protein ERCC-1

1

1

Small-scale

0.618

High

464397

VP37B
Vacuolar protein sorting-associated protein 37B

2

0

High-throughput

0.601

High

464368

IMA5
Importin subunit alpha-5

2

0

High-throughput

0.576

High

464392

UHRF1
E3 ubiquitin-protein ligase UHRF1

1

1

Small-scale

0.561

High

464365

RAD52
DNA repair protein RAD52 homolog

1

0

Small-scale

0.537

High

464367

CDK7
Cyclin-dependent kinase 7

1

1

High-throughput

0.536

High

185143

FANCG
Fanconi anemia group G protein

1

0

Small-scale

0.529

High

464375

MKRN3
E3 ubiquitin-protein ligase makorin-3

1

1

High-throughput

0.523

High

303307

PDE9A
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

1

0

High-throughput

0.518

High

132424

CDC7
Cell division cycle 7-related protein kinase

1

0

High-throughput

0.513

High

362617

EGFR
Epidermal growth factor receptor

1

0

Small-scale

0.513

High

445108

S10A6
Protein S100-A6

1

0

High-throughput

0.513

High

464370

PLK1
Serine/threonine-protein kinase PLK1

1

0

High-throughput

0.513

High

464393

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.513

High

302332

RNF8
E3 ubiquitin-protein ligase RNF8

1

1

Small-scale

0.500

High

421328

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

464355

RFA2
Replication protein A 32 kDa subunit

1

0

Small-scale

0.480

High

464360

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

Small-scale

0.480

High

464362

RFA3
Replication protein A 14 kDa subunit

1

0

Small-scale

0.480

High

464364

MSH2
DNA mismatch repair protein Msh2

1

2

Small-scale

0.479

High

464373

TP53B
TP53-binding protein 1

1

1

High-throughput

0.479

High

464377

MDC1
Mediator of DNA damage checkpoint protein 1

1

1

High-throughput

0.479

High

464382

Q6NSB6
MKRN3 protein

1

1

High-throughput

0.470

High

464356

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

464357

TBP
TATA-box-binding protein

1

0

Small-scale

0.458

High

464359

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

Small-scale

0.458

High

464361

TF2H1
General transcription factor IIH subunit 1

1

0

Small-scale

0.458

High

464363

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.458

High

464366

TAF6
Transcription initiation factor TFIID subunit 6

1

0

Small-scale

0.458

High

464371

DCAF7
DDB1- and CUL4-associated factor 7

1

0

Small-scale

0.458

High

464372

H2B1C
Histone H2B type 1-C/E/F/G/I

1

0

High-throughput

0.458

High

464374

TAF10
Transcription initiation factor TFIID subunit 10

1

0

Small-scale

0.458

High

464376

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

0

Small-scale

0.458

High

464379

TAF7
Transcription initiation factor TFIID subunit 7

1

0

Small-scale

0.458

High

464380

TAF12
Transcription initiation factor TFIID subunit 12

1

0

Small-scale

0.458

High

464385

SIR6
NAD-dependent protein deacylase sirtuin-6

1

0

High-throughput

0.458

High

464398

CASS4
Cas scaffolding protein family member 4

1

0

High-throughput

0.438

High

464396

MAGIX
PDZ domain-containing protein MAGIX

3

0

High-throughput

0.347

High

464381

SLX4I
Protein SLX4IP

3

0

Small-scale

0.342

High

353664

DRC4
Dynein regulatory complex subunit 4

2

0

High-throughput

0.316

High

464386

USBP1
Harmonin-binding protein USHBP1

1

0

High-throughput

0.299

High

464389

TRM2B
tRNA

1

0

High-throughput

0.299

High

464369

KIF11
Kinesin-like protein KIF11

1

0

Small-scale

0.292

High

464354

ACM5
Muscarinic acetylcholine receptor M5

1

0

High-throughput

0.282

High

244632

ZC3H1
Zinc finger C3H1 domain-containing protein

1

0

High-throughput

0.279

Low

386425

SPTA1
Spectrin alpha chain, erythrocytic 1

1

0

Small-scale

0.249

Low

464378

NFIX
Nuclear factor 1 X-type

1

0

High-throughput

0.249

Low

464388

SPDLY
Protein Spindly

1

0

High-throughput

0.249

Low

464395

GOLP3
Golgi phosphoprotein 3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025