Protein: ORC4
Origin recognition complex subunit 4

Gene: ORC4
Organism: Homo sapiens
Interactions: 97
UniProt ID: O43929

Gene Ontology (top 5):
GO:0000166 - nucleotide binding
GO:0000781 - chromosome, telomeric region
GO:0000808 - origin recognition complex
GO:0003688 - DNA replication origin binding
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

217799

ORC2
Origin recognition complex subunit 2

12

13

Small-scale

0.979

High

217213

ORC5
Origin recognition complex subunit 5

7

19

Small-scale

0.953

High

217839

ORC3
Origin recognition complex subunit 3

6

13

Small-scale

0.935

High

217798

ORC1
Origin recognition complex subunit 1

5

13

Small-scale

0.921

High

217775

MCM3
DNA replication licensing factor MCM3

2

20

Small-scale

0.793

High

217846

ORC6
Origin recognition complex subunit 6

4

6

Small-scale

0.698

High

217780

MCM7
DNA replication licensing factor MCM7

1

19

High-throughput

0.692

High

217821

LACC1
Purine nucleoside phosphorylase LACC1

3

0

High-throughput

0.629

High

217779

MCM4
DNA replication licensing factor MCM4

1

18

Small-scale

0.621

High

217789

MCM2
DNA replication licensing factor MCM2

1

20

Small-scale

0.621

High

217802

MCM6
DNA replication licensing factor MCM6

1

20

Small-scale

0.621

High

217841

LRWD1
Leucine-rich repeat and WD repeat-containing protein 1

2

2

Small-scale

0.611

High

217773

RFA2
Replication protein A 32 kDa subunit

2

2

Small-scale

0.586

High

217762

ESR1
Estrogen receptor

2

4

High-throughput

0.571

High

217818

RIR2B
Ribonucleoside-diphosphate reductase subunit M2 B

1

0

High-throughput

0.557

High

217772

ITF2
Transcription factor 4

1

0

High-throughput

0.549

High

217774

CCND1
G1/S-specific cyclin-D1

1

9

High-throughput

0.536

High

217786

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

1

High-throughput

0.536

High

217817

MCM10
Protein MCM10 homolog

1

4

High-throughput

0.536

High

217767

LAMP1
Lysosome-associated membrane glycoprotein 1

1

3

High-throughput

0.536

High

217795

AKA12
A-kinase anchor protein 12

1

1

High-throughput

0.536

High

217796

FOXL1
Forkhead box protein L1

1

3

High-throughput

0.536

High

217809

H2B2E
Histone H2B type 2-E

1

5

High-throughput

0.536

High

217832

TSNAX
Translin-associated protein X

1

1

High-throughput

0.536

High

217838

PD1L1
Programmed cell death 1 ligand 1

1

2

High-throughput

0.536

High

217787

CAZA2
F-actin-capping protein subunit alpha-2

1

0

High-throughput

0.513

High

217806

TEAD2
Transcriptional enhancer factor TEF-4

1

0

High-throughput

0.513

High

217813

PARM1
Prostate androgen-regulated mucin-like protein 1

1

0

High-throughput

0.513

High

217820

PDPN
Podoplanin

1

0

High-throughput

0.513

High

217822

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

217823

LRC25
Leucine-rich repeat-containing protein 25

1

0

High-throughput

0.513

High

217831

P2RX4
P2X purinoceptor 4

1

0

High-throughput

0.513

High

217764

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.501

High

59715

KLRG2
Killer cell lectin-like receptor subfamily G member 2

1

1

High-throughput

0.489

High

217756

ICOSL
ICOS ligand

1

3

High-throughput

0.489

High

217757

NCTR1
Natural cytotoxicity triggering receptor 1

1

1

High-throughput

0.489

High

217759

VAMP5
Vesicle-associated membrane protein 5

1

7

High-throughput

0.489

High

217760

TNF6B
Tumor necrosis factor receptor superfamily member 6B

1

6

High-throughput

0.489

High

217776

TNR5
Tumor necrosis factor receptor superfamily member 5

1

7

High-throughput

0.489

High

217785

OX2G
OX-2 membrane glycoprotein

1

2

High-throughput

0.489

High

217793

DLK1
Protein delta homolog 1

1

1

High-throughput

0.489

High

217807

NSDHL
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

1

1

High-throughput

0.489

High

217810

MICA
MHC class I polypeptide-related sequence A

1

1

High-throughput

0.489

High

217811

KLC3
Kinesin light chain 3

1

1

High-throughput

0.489

High

217814

VSTM1
V-set and transmembrane domain-containing protein 1

1

1

High-throughput

0.489

High

217835

C1QR1
Complement component C1q receptor

1

1

High-throughput

0.489

High

217837

SCN3B
Sodium channel regulatory subunit beta-3

1

1

High-throughput

0.489

High

217845

CAH14
Carbonic anhydrase 14

1

1

High-throughput

0.489

High

217784

MLH1
DNA mismatch repair protein Mlh1

1

2

High-throughput

0.481

High

217790

IMA5
Importin subunit alpha-5

1

3

High-throughput

0.481

High

217797

CTBP1
C-terminal-binding protein 1

1

1

High-throughput

0.481

High

217826

FBX25
F-box only protein 25

1

1

High-throughput

0.481

High

217844

MTUS1
Microtubule-associated tumor suppressor 1

1

3

High-throughput

0.481

High

213988

SPOP
Speckle-type POZ protein

1

4

High-throughput

0.479

High

217755

PRKN
E3 ubiquitin-protein ligase parkin

1

6

High-throughput

0.479

High

217758

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.479

High

217768

XRCC6
X-ray repair cross-complementing protein 6

1

3

Small-scale

0.479

High

217769

XRCC5
X-ray repair cross-complementing protein 5

1

3

Small-scale

0.479

High

217777

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

217782

PHB1
Prohibitin 1

1

1

High-throughput

0.479

High

217783

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.479

High

217788

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

High-throughput

0.479

High

217792

H31
Histone H3.1

1

3

High-throughput

0.479

High

217794

H33
Histone H3.3

1

3

High-throughput

0.479

High

217800

SNW1
SNW domain-containing protein 1

1

1

High-throughput

0.479

High

217804

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

217805

BRD3
Bromodomain-containing protein 3

1

2

High-throughput

0.479

High

217819

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.479

High

217830

CDC5L
Cell division cycle 5-like protein

1

3

High-throughput

0.479

High

217840

DBF4A
Protein DBF4 homolog A

1

1

Small-scale

0.479

High

217828

FBXL8
F-box/LRR-repeat protein 8

1

0

High-throughput

0.460

High

217836

FBX6
F-box only protein 6

1

0

High-throughput

0.460

High

217843

FBXL5
F-box/LRR-repeat protein 5

1

0

High-throughput

0.460

High

217763

CATA
Catalase

1

0

High-throughput

0.458

High

217801

MTMR3
Myotubularin-related protein 3

1

0

High-throughput

0.458

High

217803

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

217825

SNIP1
Smad nuclear-interacting protein 1

1

0

High-throughput

0.458

High

217770

CCL2
C-C motif chemokine 2

1

1

Small-scale

0.437

High

217815

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

217833

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.437

High

217816

TBA1A
Tubulin alpha-1A chain

1

0

High-throughput

0.426

High

217791

H4
Histone H4

1

5

High-throughput

0.408

High

217808

H31T
Histone H3.1t

1

3

High-throughput

0.408

High

217827

RDH5
Retinol dehydrogenase 5

1

0

High-throughput

0.292

High

213092

SNG1
Synaptogyrin-1

1

0

High-throughput

0.279

Low

217761

TGFA
Protransforming growth factor alpha [Cleaved into: Transforming growth factor alpha

1

0

High-throughput

0.279

Low

217765

ITA5
Integrin alpha-5

1

0

High-throughput

0.279

Low

217766

GIP
Gastric inhibitory polypeptide

1

0

High-throughput

0.279

Low

217771

PVR
Poliovirus receptor

1

0

High-throughput

0.279

Low

217778

IL1R2
Interleukin-1 receptor type 2

1

0

High-throughput

0.279

Low

217781

SDC2
Syndecan-2

1

0

High-throughput

0.279

Low

217812

TM154
Transmembrane protein 154

1

0

High-throughput

0.279

Low

217824

LRN4L
LRRN4 C-terminal-like protein

1

0

High-throughput

0.279

Low

217829

TXD15
Thioredoxin domain-containing protein 15

1

0

High-throughput

0.279

Low

217834

SPRNG
SREBP regulating gene protein

1

0

High-throughput

0.279

Low

217842

FLOWR
Calcium channel flower homolog

1

0

High-throughput

0.279

Low

217847

NPTN
Neuroplastin

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024