Protein: TPM1
Tropomyosin alpha-1 chain (Alpha-tropomyosin) (Tropomyosin-1)

Gene: TPM1
Organism: Homo sapiens
Interactions: 201
UniProt ID: P09493

Gene Ontology (top 5):
GO:0001725 - stress fiber
GO:0003065 - positive regulation of heart rate by epinephrine
GO:0003779 - actin binding
GO:0005200 - structural constituent of cytoskeleton
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

434329

TPM2
Tropomyosin beta chain

6

16

Small-scale

0.947

High

451235

TPM4
Tropomyosin alpha-4 chain

5

15

High-throughput

0.923

High

451185

TNNT1
Troponin T, slow skeletal muscle

4

3

Small-scale

0.919

High

418851

TPM3
Tropomyosin alpha-3 chain

3

16

High-throughput

0.847

High

451176

TPM1
Tropomyosin alpha-1 chain

2

15

Small-scale

0.768

High

451336

MD1L1
Mitotic spindle assembly checkpoint protein MAD1

8

20

High-throughput

0.757

High

451201

MYH9
Myosin-9

1

6

High-throughput

0.691

High

451293

MY18A
Unconventional myosin-XVIIIa

1

13

High-throughput

0.691

High

451310

KXDL1
KxDL motif-containing protein 1

8

5

High-throughput

0.691

High

451267

CROCC
Rootletin

3

9

High-throughput

0.667

High

451278

HOME1
Homer protein homolog 1

3

9

High-throughput

0.667

High

451288

DLG5
Disks large homolog 5

3

3

High-throughput

0.667

High

451297

EXOC4
Exocyst complex component 4

3

1

High-throughput

0.667

High

451304

SCLT1
Sodium channel and clathrin linker 1

3

20

High-throughput

0.667

High

451319

CNTLN
Centlein

3

8

High-throughput

0.667

High

451327

KLH21
Kelch-like protein 21

3

1

High-throughput

0.667

High

451337

NEMO
NF-kappa-B essential modulator

3

16

High-throughput

0.667

High

451236

ACTC
Actin, alpha cardiac muscle 1

1

10

High-throughput

0.665

High

451338

V9HW56
Tropomyosin alpha-4 chain

1

15

High-throughput

0.665

High

451179

TFPT
TCF3 fusion partner

2

4

High-throughput

0.654

High

451184

CFTR
Cystic fibrosis transmembrane conductance regulator

3

3

High-throughput

0.650

High

451212

TNNT2
Troponin T, cardiac muscle

1

3

Small-scale

0.647

High

451253

NUCG
Endonuclease G, mitochondrial

3

0

High-throughput

0.638

High

451280

SYCE1
Synaptonemal complex central element protein 1

3

3

High-throughput

0.630

High

229619

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

2

8

High-throughput

0.628

High

451231

ACTA
Actin, aortic smooth muscle

1

10

High-throughput

0.618

High

451234

ACTG
Actin, cytoplasmic 2

1

10

High-throughput

0.618

High

451301

MYO19
Unconventional myosin-XIX

1

9

High-throughput

0.618

High

451195

1433T
14-3-3 protein theta

2

10

High-throughput

0.611

High

451317

ANLN
Anillin

2

4

High-throughput

0.611

High

451290

RUFY2
RUN and FYVE domain-containing protein 2

3

14

High-throughput

0.609

High

451296

C102A
Coiled-coil domain-containing protein 102A

3

10

High-throughput

0.609

High

451335

TSSC4
U5 small nuclear ribonucleoprotein TSSC4

3

1

High-throughput

0.609

High

451262

CF184
Cilia- and flagella-associated protein 184

3

2

High-throughput

0.607

High

451279

FAM9C
Protein FAM9C

3

5

High-throughput

0.607

High

451230

PRS8
26S proteasome regulatory subunit 8

2

6

High-throughput

0.606

High

451287

CCHCR
Coiled-coil alpha-helical rod protein 1

2

13

High-throughput

0.606

High

451330

BL1S6
Biogenesis of lysosome-related organelles complex 1 subunit 6

2

2

High-throughput

0.606

High

451245

GOGA2
Golgin subfamily A member 2

2

12

High-throughput

0.597

High

451222

CNN1
Calponin-1

2

7

Small-scale

0.585

High

451252

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

2

15

High-throughput

0.584

High

157413

IFIT3
Interferon-induced protein with tetratricopeptide repeats 3

1

2

High-throughput

0.582

High

317397

YETS4
YEATS domain-containing protein 4

2

0

High-throughput

0.580

High

368850

ESR1
Estrogen receptor

2

13

High-throughput

0.571

High

451187

JUND
Transcription factor JunD

2

12

High-throughput

0.558

High

361733

FIBA
Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain]

2

4

High-throughput

0.553

High

310892

SNAPN
SNARE-associated protein Snapin

1

6

High-throughput

0.541

High

451271

MAST2
Microtubule-associated serine/threonine-protein kinase 2

1

10

High-throughput

0.541

High

128406

DNM1L
Dynamin-1-like protein

1

1

High-throughput

0.536

High

213885

DYRK3
Dual specificity tyrosine-phosphorylation-regulated kinase 3

1

17

High-throughput

0.536

High

262224

ULK1
Serine/threonine-protein kinase ULK1

1

10

High-throughput

0.536

High

451181

TAU
Microtubule-associated protein tau

1

5

High-throughput

0.536

High

451186

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

11

High-throughput

0.536

High

451204

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

1

High-throughput

0.536

High

451207

PSB10
Proteasome subunit beta type-10

1

3

High-throughput

0.536

High

451220

RB27A
Ras-related protein Rab-27A

1

1

High-throughput

0.536

High

451226

RAP1B
Ras-related protein Rap-1b

1

6

High-throughput

0.536

High

451228

1433G
14-3-3 protein gamma

1

10

High-throughput

0.536

High

451277

PIM3
Serine/threonine-protein kinase pim-3

1

11

High-throughput

0.536

High

451307

PARK7
Parkinson disease protein 7

1

3

High-throughput

0.536

High

451326

AAKG2
5'-AMP-activated protein kinase subunit gamma-2

1

3

High-throughput

0.536

High

451328

HSPB8
Heat shock protein beta-8

1

5

High-throughput

0.536

High

451331

EXOC7
Exocyst complex component 7

1

3

High-throughput

0.536

High

451285

CA216
UPF0500 protein C1orf216

1

2

High-throughput

0.523

High

451302

LRCH3
DISP complex protein LRCH3

1

0

High-throughput

0.513

High

451189

NEBU
Nebulin

1

2

Small-scale

0.501

High

451225

CDC42
Cell division control protein 42 homolog

1

14

High-throughput

0.501

High

451211

GATA4
Transcription factor GATA-4

1

2

High-throughput

0.500

High

451221

STA5B
Signal transducer and activator of transcription 5B

1

3

High-throughput

0.500

High

451223

NKX25
Homeobox protein Nkx-2.5

1

5

High-throughput

0.500

High

451238

ELF3
ETS-related transcription factor Elf-3

1

2

High-throughput

0.500

High

451242

IRF8
Interferon regulatory factor 8

1

1

High-throughput

0.500

High

451200

CBS
Cystathionine beta-synthase

1

0

High-throughput

0.493

High

451177

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

1

High-throughput

0.489

High

451192

VDAC1
Voltage-dependent anion-selective channel protein 1

1

3

High-throughput

0.489

High

451202

SOAT1
Sterol O-acyltransferase 1

1

2

High-throughput

0.489

High

451217

NEST
Nestin

1

7

High-throughput

0.489

High

451224

GEM
GTP-binding protein GEM

1

6

High-throughput

0.489

High

451239

HTRA4
Serine protease HTRA4

1

1

High-throughput

0.489

High

451243

SUH
Recombining binding protein suppressor of hairless

1

1

High-throughput

0.489

High

451256

FL2D
Pre-mRNA-splicing regulator WTAP

1

2

High-throughput

0.489

High

451264

EAPP
E2F-associated phosphoprotein

1

1

High-throughput

0.489

High

451274

IKIP
Inhibitor of nuclear factor kappa-B kinase-interacting protein

1

4

High-throughput

0.489

High

451275

COX15
Heme A synthase COX15

1

1

High-throughput

0.489

High

451294

ESR2
Estrogen receptor beta

1

13

Small-scale

0.489

High

66256

WASH1
WASH complex subunit 1

1

1

High-throughput

0.481

High

337815

EGFR
Epidermal growth factor receptor

1

3

Small-scale

0.481

High

451316

NOD2
Nucleotide-binding oligomerization domain-containing protein 2

1

2

Small-scale

0.481

High

120284

RHOD
Rho-related GTP-binding protein RhoD

1

17

High-throughput

0.479

High

122459

MEN1
Menin

1

1

High-throughput

0.479

High

226323

PRKN
E3 ubiquitin-protein ligase parkin

1

5

High-throughput

0.479

High

231047

OPA1
Dynamin-like GTPase OPA1, mitochondrial

1

4

High-throughput

0.479

High

282493

RNF8
E3 ubiquitin-protein ligase RNF8

1

6

High-throughput

0.479

High

298081

UFL1
E3 UFM1-protein ligase 1

1

1

High-throughput

0.479

High

301563

TRI37
E3 ubiquitin-protein ligase TRIM37

1

13

High-throughput

0.479

High

322097

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.479

High

345288

FOS
Protein c-Fos

1

12

High-throughput

0.479

High

352454

TNFA
Tumor necrosis factor

1

9

High-throughput

0.479

High

361433

APOE
Apolipoprotein E

1

1

High-throughput

0.479

High

373564

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

7

High-throughput

0.479

High

385954

P53
Cellular tumor antigen p53

1

4

Small-scale

0.479

High

397736

ISG15
Ubiquitin-like protein ISG15

1

7

High-throughput

0.479

High

434905

SP1
Transcription factor Sp1

1

8

Small-scale

0.479

High

451180

ANDR
Androgen receptor

1

13

High-throughput

0.479

High

451182

ERG
Transcriptional regulator ERG

1

3

Small-scale

0.479

High

451183

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

2

High-throughput

0.479

High

451188

BTF3
Transcription factor BTF3

1

3

High-throughput

0.479

High

451191

FLNA
Filamin-A

1

6

High-throughput

0.479

High

451193

CDK2
Cyclin-dependent kinase 2

1

7

High-throughput

0.479

High

451194

MT3
Metallothionein-3

1

1

Small-scale

0.479

High

451196

TMOD1
Tropomodulin-1

1

6

High-throughput

0.479

High

451198

CTNB1
Catenin beta-1

1

4

High-throughput

0.479

High

451208

CCNF
Cyclin-F

1

2

High-throughput

0.479

High

451210

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

3

High-throughput

0.479

High

451213

YAP1
Transcriptional coactivator YAP1

1

5

High-throughput

0.479

High

451214

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

5

High-throughput

0.479

High

451215

CAZA2
F-actin-capping protein subunit alpha-2

1

5

High-throughput

0.479

High

451216

CAPZB
F-actin-capping protein subunit beta

1

3

High-throughput

0.479

High

451218

CDK7
Cyclin-dependent kinase 7

1

7

High-throughput

0.479

High

451227

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.479

High

451229

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

8

High-throughput

0.479

High

451237

H31
Histone H3.1

1

2

High-throughput

0.479

High

451240

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

2

Small-scale

0.479

High

451244

GOGA3
Golgin subfamily A member 3

1

11

High-throughput

0.479

High

451246

EP300
Histone acetyltransferase p300

1

5

High-throughput

0.479

High

451247

FOXO1
Forkhead box protein O1

1

4

High-throughput

0.479

High

451248

TFCP2
Alpha-globin transcription factor CP2

1

1

High-throughput

0.479

High

451249

TRI26
Tripartite motif-containing protein 26

1

4

Small-scale

0.479

High

451251

G3BP1
Ras GTPase-activating protein-binding protein 1

1

2

High-throughput

0.479

High

451257

TNIP1
TNFAIP3-interacting protein 1

1

17

High-throughput

0.479

High

451258

KIF14
Kinesin-like protein KIF14

1

6

High-throughput

0.479

High

451261

DREB
Drebrin

1

2

High-throughput

0.479

High

451263

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

4

High-throughput

0.479

High

451265

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

7

Small-scale

0.479

High

451270

ZN746
Zinc finger protein 746

1

1

High-throughput

0.479

High

451282

SYNPO
Synaptopodin

1

4

High-throughput

0.479

High

451292

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

4

High-throughput

0.479

High

451295

FBXW7
F-box/WD repeat-containing protein 7

1

2

High-throughput

0.479

High

451299

CHM4C
Charged multivesicular body protein 4c

1

1

High-throughput

0.479

High

451303

RHOV
Rho-related GTP-binding protein RhoV

1

18

High-throughput

0.479

High

451311

RHBT2
Rho-related BTB domain-containing protein 2

1

18

High-throughput

0.479

High

451315

ECT2
Protein ECT2

1

4

High-throughput

0.479

High

451318

PDLI7
PDZ and LIM domain protein 7

1

11

High-throughput

0.479

High

451322

SYLC
Leucine--tRNA ligase, cytoplasmic

1

2

High-throughput

0.479

High

451323

HDAC6
Histone deacetylase 6

1

7

High-throughput

0.479

High

451324

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

451325

TES
Testin

1

12

High-throughput

0.479

High

451329

BAG5
BAG family molecular chaperone regulator 5

1

1

High-throughput

0.479

High

451334

RIPK3
Receptor-interacting serine/threonine-protein kinase 3

1

1

High-throughput

0.479

High

451203

TGFR1
TGF-beta receptor type-1

1

0

Small-scale

0.458

High

451276

SLN11
Schlafen family member 11

1

0

Small-scale

0.458

High

451309

MYOC
Myocilin

1

0

Small-scale

0.458

High

451313

TOLIP
Toll-interacting protein

1

0

High-throughput

0.458

High

234698

ZIC3
Zinc finger protein ZIC 3

1

5

High-throughput

0.457

High

451197

TLX1
T-cell leukemia homeobox protein 1

1

3

High-throughput

0.457

High

401292

JUN
Transcription factor Jun

1

13

High-throughput

0.445

High

451199

BMI1
Polycomb complex protein BMI-1

1

9

High-throughput

0.445

High

451232

GRB2
Growth factor receptor-bound protein 2

1

5

High-throughput

0.445

High

451233

1433Z
14-3-3 protein zeta/delta

1

10

High-throughput

0.445

High

451268

PKHA7
Pleckstrin homology domain-containing family A member 7

1

11

High-throughput

0.445

High

167810

NPC1
NPC intracellular cholesterol transporter 1

1

1

High-throughput

0.437

High

328711

TOP3B
DNA topoisomerase 3-beta-1

1

1

High-throughput

0.437

High

345753

MYC
Myc proto-oncogene protein

1

7

High-throughput

0.437

High

378935

MYCN
N-myc proto-oncogene protein

1

7

High-throughput

0.437

High

390669

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

2

High-throughput

0.437

High

451178

FURIN
Furin

1

3

High-throughput

0.437

High

451205

BRCA1
Breast cancer type 1 susceptibility protein

1

6

High-throughput

0.437

High

451209

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

3

High-throughput

0.437

High

451219

CDK9
Cyclin-dependent kinase 9

1

10

High-throughput

0.437

High

451241

IFM3
Interferon-induced transmembrane protein 3

1

2

High-throughput

0.437

High

451250

FOXL1
Forkhead box protein L1

1

1

High-throughput

0.437

High

451255

MDC1
Mediator of DNA damage checkpoint protein 1

1

3

High-throughput

0.437

High

451259

SIX1
Homeobox protein SIX1

1

2

Small-scale

0.437

High

451260

EZH2
Histone-lysine N-methyltransferase EZH2

1

2

High-throughput

0.437

High

451269

TET2
Methylcytosine dioxygenase TET2

1

2

Small-scale

0.437

High

451283

FHI1B
FHF complex subunit HOOK-interacting protein 1B

1

2

High-throughput

0.437

High

451289

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

1

High-throughput

0.437

High

451291

CLC4D
C-type lectin domain family 4 member D

1

3

High-throughput

0.437

High

451298

CLUA1
Clusterin-associated protein 1

1

1

High-throughput

0.437

High

451300

VMP1
Vacuole membrane protein 1

1

9

High-throughput

0.437

High

451305

PEO1
Twinkle mtDNA helicase

1

1

High-throughput

0.437

High

451306

KCD15
BTB/POZ domain-containing protein KCTD15

1

1

Small-scale

0.437

High

451312

DDX24
ATP-dependent RNA helicase DDX24

1

3

High-throughput

0.437

High

451314

PKHA4
Pleckstrin homology domain-containing family A member 4

1

7

High-throughput

0.437

High

451320

RN181
E3 ubiquitin-protein ligase RNF181

1

2

High-throughput

0.437

High

451321

CFA97
Cilia- and flagella-associated protein 97

1

2

High-throughput

0.437

High

451333

AKT3
RAC-gamma serine/threonine-protein kinase

1

7

High-throughput

0.437

High

451190

CD3Z
T-cell surface glycoprotein CD3 zeta chain

1

0

High-throughput

0.426

High

239726

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

3

High-throughput

0.407

High

362623

APOH
Beta-2-glycoprotein 1

1

1

Small-scale

0.407

High

451266

LITD1
LINE-1 type transposase domain-containing protein 1

1

2

High-throughput

0.407

High

451308

ZBT18
Zinc finger and BTB domain-containing protein 18

1

5

High-throughput

0.407

High

451286

CAGE1
Cancer-associated gene 1 protein

2

0

High-throughput

0.343

High

451206

COIA1
Collagen alpha-1(XVIII) chain [Cleaved into: Endostatin; Non-collagenous domain 1

2

0

Small-scale

0.322

High

451281

CLIP4
CAP-Gly domain-containing linker protein 4

1

0

High-throughput

0.282

High

451332

PIN4
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4

1

0

High-throughput

0.279

Low

451272

GLT18
Polypeptide N-acetylgalactosaminyltransferase 18

1

0

High-throughput

0.269

Low

451284

CC112
Coiled-coil domain-containing protein 112

1

0

High-throughput

0.269

Low

451254

RBM39
RNA-binding protein 39

1

0

High-throughput

0.249

Low

451273

TIFAB
TRAF-interacting protein with FHA domain-containing protein B

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024