Protein: COMT
Catechol O-methyltransferase (EC 2.1.1.6)

Gene: COMT
Organism: Homo sapiens
Interactions: 172
UniProt ID: P21964

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0001662 - behavioral fear response
GO:0001666 - response to hypoxia
GO:0001963 - synaptic transmission, dopaminergic
GO:0001964 - startle response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

642200

CTR1
High affinity cationic amino acid transporter 1

3

2

High-throughput

0.647

High

642247

TM205
Transmembrane protein 205

3

0

High-throughput

0.636

High

642230

PCH2
Pachytene checkpoint protein 2 homolog

3

1

High-throughput

0.628

High

166084

FFAR3
Free fatty acid receptor 3

2

1

High-throughput

0.606

High

291722

CXB3
Gap junction beta-3 protein

2

3

High-throughput

0.606

High

328630

VAMP5
Vesicle-associated membrane protein 5

2

1

High-throughput

0.606

High

642203

CNR2
Cannabinoid receptor 2

2

3

High-throughput

0.606

High

642232

VAMP3
Vesicle-associated membrane protein 3

2

1

High-throughput

0.606

High

642262

GP152
Probable G-protein coupled receptor 152

2

1

High-throughput

0.606

High

642270

CR3L1
Cyclic AMP-responsive element-binding protein 3-like protein 1

2

1

High-throughput

0.606

High

642278

S1PR3
Sphingosine 1-phosphate receptor 3

2

3

High-throughput

0.606

High

642296

S39A2
Zinc transporter ZIP2

2

8

High-throughput

0.606

High

642299

CXB4
Gap junction beta-4 protein

2

3

High-throughput

0.606

High

642303

S39A1
Zinc transporter ZIP1

2

8

High-throughput

0.606

High

642311

LAT2
Large neutral amino acids transporter small subunit 2

2

2

High-throughput

0.606

High

642276

RUFY1
RUN and FYVE domain-containing protein 1

2

0

High-throughput

0.585

High

64733

MADL2
Myeloid-associated differentiation marker-like protein 2

2

0

High-throughput

0.580

High

74152

SMIM1
Small integral membrane protein 1

2

0

High-throughput

0.580

High

253142

MOT2
Monocarboxylate transporter 2

2

0

High-throughput

0.580

High

292486

RHBL1
Rhomboid-related protein 1

2

0

High-throughput

0.580

High

332781

KCNK5
Potassium channel subfamily K member 5

2

0

High-throughput

0.580

High

346711

TM50A
Transmembrane protein 50A

2

0

High-throughput

0.580

High

642192

GTR5
Solute carrier family 2, facilitated glucose transporter member 5

2

0

High-throughput

0.580

High

642199

V2R
Vasopressin V2 receptor

2

0

High-throughput

0.580

High

642204

TRFR
Thyrotropin-releasing hormone receptor

2

0

High-throughput

0.580

High

642209

EMD
Emerin

2

0

High-throughput

0.580

High

642223

NIPA4
Magnesium transporter NIPA4

2

0

High-throughput

0.580

High

642227

TM187
Transmembrane protein 187

2

0

High-throughput

0.580

High

642235

SOAT
Sodium-dependent organic anion transporter

2

0

High-throughput

0.580

High

642236

F209A
Protein FAM209A

2

0

High-throughput

0.580

High

642237

MF14B
Hippocampus abundant transcript-like protein 1

2

0

High-throughput

0.580

High

642245

HRG1
Heme transporter HRG1

2

0

High-throughput

0.580

High

642249

OTOP3
Proton channel OTOP3

2

0

High-throughput

0.580

High

642252

PLPP6
Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6

2

0

High-throughput

0.580

High

642259

BEST2
Bestrophin-2a

2

0

High-throughput

0.580

High

642273

TLCD4
TLC domain-containing protein 4

2

0

High-throughput

0.580

High

642287

TM222
Transmembrane protein 222

2

0

High-throughput

0.580

High

642302

TM100
Transmembrane protein 100

2

0

High-throughput

0.580

High

642312

PGAP2
Acyltransferase PGAP2

2

0

High-throughput

0.580

High

642315

THS7A
Thrombospondin type-1 domain-containing protein 7A [Cleaved into: Thrombospondin type-1 domain-containing protein 7A, soluble form]

2

0

High-throughput

0.580

High

642318

SELK
Selenoprotein K

2

0

High-throughput

0.580

High

642229

K1H1
Keratin, type I cuticular Ha1

1

1

High-throughput

0.573

High

642243

K1C40
Keratin, type I cytoskeletal 40

1

1

High-throughput

0.573

High

335227

CXB5
Gap junction beta-5 protein

2

3

High-throughput

0.553

High

464676

CXB1
Gap junction beta-1 protein

2

3

High-throughput

0.553

High

642244

RHBD2
Rhomboid domain-containing protein 2

2

1

High-throughput

0.553

High

642288

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

2

1

High-throughput

0.553

High

642300

TM14B
Transmembrane protein 14B

2

1

High-throughput

0.553

High

642308

TM14C
Transmembrane protein 14C

2

1

High-throughput

0.553

High

642195

KRA59
Keratin-associated protein 5-9

1

0

High-throughput

0.549

High

642198

CDC27
Cell division cycle protein 27 homolog

1

0

High-throughput

0.549

High

631058

RAB5A
Ras-related protein Rab-5A

2

0

High-throughput

0.547

High

642254

SH2D3
SH2 domain-containing protein 3C

2

0

High-throughput

0.547

High

225775

AP1G1
AP-1 complex subunit gamma-1

1

3

High-throughput

0.536

High

295724

AP1G2
AP-1 complex subunit gamma-like 2

1

3

High-throughput

0.536

High

323663

AP2A2
AP-2 complex subunit alpha-2

1

3

High-throughput

0.536

High

642214

AP1S2
AP-1 complex subunit sigma-2

1

3

High-throughput

0.536

High

642219

AP1S1
AP-1 complex subunit sigma-1A

1

3

High-throughput

0.536

High

642220

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

1

High-throughput

0.536

High

642224

AP1B1
AP-1 complex subunit beta-1

1

2

High-throughput

0.536

High

642267

US6NL
USP6 N-terminal-like protein

1

1

High-throughput

0.536

High

642274

AP1S3
AP-1 complex subunit sigma-3

1

3

High-throughput

0.536

High

642307

VAPA
Vesicle-associated membrane protein-associated protein A

1

1

High-throughput

0.536

High

642208

MTR1A
Melatonin receptor type 1A

1

0

High-throughput

0.518

High

642211

FXR2
RNA-binding protein FXR2

1

0

High-throughput

0.518

High

193393

GPR42
G-protein coupled receptor 42

1

1

High-throughput

0.515

High

642191

FGFR3
Fibroblast growth factor receptor 3

1

1

High-throughput

0.515

High

642246

Q6P5T0
AQP7 protein

1

1

High-throughput

0.515

High

389025

FINC
Fibronectin

1

0

High-throughput

0.513

High

421502

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.513

High

460909

LDHC
L-lactate dehydrogenase C chain

1

0

High-throughput

0.513

High

465938

CO1A2
Collagen alpha-2(I) chain

1

0

High-throughput

0.513

High

642225

RIN1
Ras and Rab interactor 1

1

0

High-throughput

0.513

High

642238

ODR4
Protein odr-4 homolog

1

0

High-throughput

0.513

High

642269

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.513

High

642283

AP1M1
AP-1 complex subunit mu-1

1

0

High-throughput

0.513

High

642284

TX101
Testis-expressed protein 101

1

0

High-throughput

0.513

High

642289

IPYR2
Inorganic pyrophosphatase 2, mitochondrial

1

0

High-throughput

0.513

High

642316

EXO1
Exonuclease 1

1

0

High-throughput

0.513

High

162466

ANM5
Protein arginine N-methyltransferase 5

1

0

High-throughput

0.493

High

177997

LSM1
U6 snRNA-associated Sm-like protein LSm1

1

0

High-throughput

0.493

High

301339

WFS1
Wolframin

1

0

High-throughput

0.493

High

442233

GELS
Gelsolin

1

0

High-throughput

0.493

High

633837

MPRD
Cation-dependent mannose-6-phosphate receptor

1

0

High-throughput

0.493

High

642197

EPHB2
Ephrin type-B receptor 2

1

0

High-throughput

0.493

High

642268

DVL3
Segment polarity protein dishevelled homolog DVL-3

1

0

High-throughput

0.493

High

642314

CHIP
E3 ubiquitin-protein ligase CHIP

1

0

High-throughput

0.493

High

642241

CCD18
Coiled-coil domain-containing protein 18

1

1

High-throughput

0.489

High

642206

RGS2
Regulator of G-protein signaling 2

1

0

High-throughput

0.486

High

642286

XRN2
5'-3' exoribonuclease 2

1

0

High-throughput

0.486

High

155378

AQP7
Aquaporin-7

1

1

High-throughput

0.481

High

642215

CDC42
Cell division control protein 42 homolog

1

0

High-throughput

0.480

High

293196

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.479

High

642216

RAB2A
Ras-related protein Rab-2A

1

1

High-throughput

0.479

High

642217

RAB14
Ras-related protein Rab-14

1

1

High-throughput

0.479

High

642251

GOLI
E3 ubiquitin-protein ligase RNF130

1

2

High-throughput

0.479

High

642257

RN149
E3 ubiquitin-protein ligase RNF149

1

2

High-throughput

0.479

High

642271

CHM4C
Charged multivesicular body protein 4c

1

1

High-throughput

0.479

High

642291

CHM4B
Charged multivesicular body protein 4b

1

1

High-throughput

0.479

High

642292

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

642306

WWOX
WW domain-containing oxidoreductase

1

1

High-throughput

0.479

High

642310

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

642239

SYRM
Probable arginine--tRNA ligase, mitochondrial

1

1

High-throughput

0.470

High

642256

WDR31
WD repeat-containing protein 31

1

2

High-throughput

0.470

High

642207

GLP1R
Glucagon-like peptide 1 receptor

1

0

Small-scale

0.460

High

371160

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

400279

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

402330

GBA1
Lysosomal acid glucosylceramidase

1

0

High-throughput

0.458

High

642194

CRCM
Colorectal mutant cancer protein

1

0

High-throughput

0.458

High

642210

CDK9
Cyclin-dependent kinase 9

1

0

High-throughput

0.458

High

642212

CCHL
Holocytochrome c-type synthase

1

0

High-throughput

0.458

High

642213

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

642222

KIF23
Kinesin-like protein KIF23

1

0

High-throughput

0.458

High

642228

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

642250

PEG10
Retrotransposon-derived protein PEG10

1

0

Small-scale

0.458

High

642258

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

642263

DCAKD
Dephospho-CoA kinase domain-containing protein

1

0

High-throughput

0.458

High

642265

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

642275

CRBN
Protein cereblon

1

0

Small-scale

0.458

High

642277

RING2
E3 ubiquitin-protein ligase RING2

1

0

High-throughput

0.458

High

642280

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.458

High

642282

ESYT1
Extended synaptotagmin-1

1

0

High-throughput

0.458

High

642295

MLXPL
Carbohydrate-responsive element-binding protein

1

0

Small-scale

0.458

High

642297

ANLN
Anillin

1

0

High-throughput

0.458

High

642298

FBX6
F-box only protein 6

1

0

High-throughput

0.458

High

230258

CREB3
Cyclic AMP-responsive element-binding protein 3

1

1

High-throughput

0.457

High

50085

S22AN
Solute carrier family 22 member 23

1

1

High-throughput

0.445

High

642193

HEMH
Ferrochelatase, mitochondrial

1

1

High-throughput

0.445

High

642202

CD80
T-lymphocyte activation antigen CD80

1

1

High-throughput

0.445

High

642242

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.445

High

642266

LPAR1
Lysophosphatidic acid receptor 1

1

3

High-throughput

0.445

High

642279

LITAF
Lipopolysaccharide-induced tumor necrosis factor-alpha factor

1

0

High-throughput

0.438

High

274980

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

1

High-throughput

0.437

High

642231

NSDHL
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

1

1

High-throughput

0.437

High

642261

RDH11
Retinol dehydrogenase 11

1

1

High-throughput

0.437

High

642317

HIG1A
HIG1 domain family member 1A, mitochondrial

1

1

High-throughput

0.437

High

339038

GTR10
Solute carrier family 2, facilitated glucose transporter member 10

1

0

High-throughput

0.426

High

404667

PRIO
Major prion protein

1

0

High-throughput

0.426

High

622027

CD53
Leukocyte surface antigen CD53

1

0

High-throughput

0.426

High

642264

CTL1
Choline transporter-like protein 1

1

0

High-throughput

0.426

High

91634

C9JAW5
HIG1 domain-containing protein

1

1

High-throughput

0.407

High

49628

T120B
Transmembrane protein 120B

2

0

High-throughput

0.316

High

129847

GET1
Guided entry of tail-anchored proteins factor 1

2

0

High-throughput

0.316

High

642201

3HIDH
3-hydroxyisobutyrate dehydrogenase, mitochondrial

2

0

High-throughput

0.316

High

642240

S35F1
Solute carrier family 35 member F1

2

0

High-throughput

0.316

High

642255

GP161
G-protein coupled receptor 161

2

0

High-throughput

0.316

High

642260

CC4L
C-C motif chemokine 4-like

2

0

High-throughput

0.316

High

642272

S35A4
Probable UDP-sugar transporter protein SLC35A4

2

0

High-throughput

0.316

High

642293

REEP4
Receptor expression-enhancing protein 4

2

0

High-throughput

0.316

High

478446

FGF2
Fibroblast growth factor 2

1

0

High-throughput

0.279

Low

642301

UFSP2
Ufm1-specific protease 2

1

0

High-throughput

0.279

Low

642304

CLDN1
Claudin domain-containing protein 1

1

0

High-throughput

0.279

Low

642309

CLIP2
CAP-Gly domain-containing linker protein 2

1

0

High-throughput

0.279

Low

296194

SCO1
Protein SCO1 homolog, mitochondrial

1

0

High-throughput

0.268

Low

642226

SEPT6
Septin-6

1

0

High-throughput

0.268

Low

642233

RSPO1
R-spondin-1

1

0

High-throughput

0.268

Low

642253

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.268

Low

642294

DCR1B
5' exonuclease Apollo

1

0

High-throughput

0.268

Low

642305

UTP6
U3 small nucleolar RNA-associated protein 6 homolog

1

0

High-throughput

0.268

Low

642313

RIMS3
Regulating synaptic membrane exocytosis protein 3

1

0

High-throughput

0.268

Low

642281

VKOR1
Vitamin K epoxide reductase complex subunit 1

1

0

Small-scale

0.251

Low

105335

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

259439

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.249

Low

587911

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

642196

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

642205

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

642218

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.249

Low

642221

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

642248

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

642285

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.249

Low

642290

TMX1
Thioredoxin-related transmembrane protein 1

1

0

High-throughput

0.249

Low

642234

ATG2A
Autophagy-related protein 2 homolog A

1

0

Small-scale

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025