Protein: TNKS1
Poly [ADP-ribose] polymerase tankyrase-1 (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 5) (ARTD5) (Poly [ADP-ribose] polymerase 5A) (Protein poly-ADP-ribosyltransferase tankyrase-1) (EC 2.4.2.-) (TNKS-1) (TRF1-interacting ankyrin-related ADP-ribose polymerase) (Tankyrase I) (Tankyrase-1) (TANK1)

Gene: TNKS1, TNKS
Organism: Homo sapiens
Interactions: 101
UniProt ID: O95271

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0000209 - protein polyubiquitination
GO:0000242 - pericentriolar material
GO:0000781 - chromosome, telomeric region
GO:0003950 - NAD+ ADP-ribosyltransferase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

310099

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

6

12

Small-scale

0.951

High

310030

TNKS1
Poly [ADP-ribose] polymerase tankyrase-1

5

14

Small-scale

0.917

High

170588

AXIN1
Axin-1

4

6

Small-scale

0.882

High

310071

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

2

3

High-throughput

0.783

High

310041

TERF1
Telomeric repeat-binding factor 1

16

2

Small-scale

0.765

High

310078

FNBP1
Formin-binding protein 1

1

4

Small-scale

0.756

High

310048

MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1

1

1

Small-scale

0.740

High

310100

BABA1
BRISC and BRCA1-A complex member 1

6

1

Small-scale

0.737

High

310097

RN146
E3 ubiquitin-protein ligase RNF146

4

1

Small-scale

0.711

High

166869

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

1

13

High-throughput

0.698

High

236545

GMDS
GDP-mannose 4,6 dehydratase

4

2

Small-scale

0.696

High

225117

MYPT2
Protein phosphatase 1 regulatory subunit 12B

1

19

High-throughput

0.691

High

310063

ANKS3
Ankyrin repeat and SAM domain-containing protein 3

1

17

High-throughput

0.691

High

310103

UBP25
Ubiquitin carboxyl-terminal hydrolase 25

3

5

Small-scale

0.684

High

310065

3BP5L
SH3 domain-binding protein 5-like

3

3

Small-scale

0.667

High

310072

RN166
E3 ubiquitin-protein ligase RNF166

3

3

High-throughput

0.667

High

310084

S35A5
UDP-sugar transporter protein SLC35A5

3

1

High-throughput

0.667

High

310090

EPN3
Epsin-3

3

3

High-throughput

0.667

High

310091

GO45
Golgin-45

4

0

Small-scale

0.664

High

310096

DISC1
Disrupted in schizophrenia 1 protein

3

4

High-throughput

0.661

High

310044

IF4A1
Eukaryotic initiation factor 4A-I

1

2

Small-scale

0.647

High

310104

LCAP
Leucyl-cystinyl aminopeptidase

3

2

Small-scale

0.646

High

225227

3BP5
SH3 domain-binding protein 5

3

3

Small-scale

0.645

High

310088

TB182
182 kDa tankyrase-1-binding protein

2

16

Small-scale

0.643

High

241926

PAGE4
P antigen family member 4

2

3

High-throughput

0.639

High

310085

TINF2
TERF1-interacting nuclear factor 2

3

0

Small-scale

0.634

High

224887

ZNRD2
Protein ZNRD2

2

1

High-throughput

0.628

High

310049

LRP1
Prolow-density lipoprotein receptor-related protein 1

2

6

High-throughput

0.628

High

310067

CHD1L
Chromodomain-helicase-DNA-binding protein 1-like

2

2

High-throughput

0.628

High

310069

CELF5
CUGBP Elav-like family member 5

2

4

High-throughput

0.628

High

310074

AP2M1
AP-2 complex subunit mu

2

3

High-throughput

0.628

High

310106

JIP3
C-Jun-amino-terminal kinase-interacting protein 3

2

10

High-throughput

0.628

High

310105

TNIK
TRAF2 and NCK-interacting protein kinase

1

10

High-throughput

0.621

High

310045

RAN
GTP-binding nuclear protein Ran

1

2

Small-scale

0.618

High

310056

STK11
Serine/threonine-protein kinase STK11

1

1

Small-scale

0.618

High

310081

BARD1
BRCA1-associated RING domain protein 1

1

17

Small-scale

0.618

High

310060

CE170
Centrosomal protein of 170 kDa

2

16

High-throughput

0.611

High

132694

SDCB1
Syntenin-1

2

8

High-throughput

0.606

High

310042

TCL1A
T-cell leukemia/lymphoma protein 1A

2

0

High-throughput

0.580

High

310064

EPMIP
EPM2A-interacting protein 1

2

0

High-throughput

0.580

High

310101

ADPRS
ADP-ribosylhydrolase ARH3

2

0

High-throughput

0.580

High

310111

OARD1
ADP-ribose glycohydrolase OARD1

2

0

High-throughput

0.580

High

310087

FACD2
Fanconi anemia group D2 protein

1

2

Small-scale

0.578

High

310109

AXIN2
Axin-2

1

6

Small-scale

0.575

High

59722

KLRG2
Killer cell lectin-like receptor subfamily G member 2

2

1

High-throughput

0.574

High

310062

F117B
Protein FAM117B

2

1

High-throughput

0.574

High

310070

ARH40
Rho guanine nucleotide exchange factor 40

2

12

High-throughput

0.571

High

310039

CDN1A
Cyclin-dependent kinase inhibitor 1

1

2

Small-scale

0.561

High

310043

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

7

Small-scale

0.561

High

310066

MAVS
Mitochondrial antiviral-signaling protein

1

9

Small-scale

0.561

High

310053

MDC1
Mediator of DNA damage checkpoint protein 1

1

7

Small-scale

0.552

High

234170

PEPL
Periplakin

1

20

High-throughput

0.536

High

280009

MPDZ
Multiple PDZ domain protein

1

4

High-throughput

0.536

High

308280

KI20A
Kinesin-like protein KIF20A

1

6

High-throughput

0.536

High

310031

FRIL
Ferritin light chain

1

1

High-throughput

0.536

High

310033

HXB2
Homeobox protein Hox-B2

1

17

High-throughput

0.536

High

310050

STRN3
Striatin-3

1

9

High-throughput

0.536

High

310082

SOST
Sclerostin

1

1

High-throughput

0.536

High

310035

EPHA1
Ephrin type-A receptor 1

1

6

High-throughput

0.528

High

310054

NUMA1
Nuclear mitotic apparatus protein 1

1

12

Small-scale

0.527

High

260693

H2AY
Core histone macro-H2A.1

1

3

Small-scale

0.515

High

310032

XRCC6
X-ray repair cross-complementing protein 6

1

1

High-throughput

0.515

High

310058

INAVA
Innate immunity activator protein

1

0

Small-scale

0.513

High

310083

PYM1
Partner of Y14 and mago

1

0

High-throughput

0.513

High

310089

REN3A
Regulator of nonsense transcripts 3A

1

0

High-throughput

0.513

High

310095

M1IP1
Mid1-interacting protein 1

1

0

High-throughput

0.513

High

310107

SL9A8
Sodium/hydrogen exchanger 8

1

0

High-throughput

0.513

High

253283

PLCH2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2

1

1

High-throughput

0.501

High

310040

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

3

High-throughput

0.501

High

310051

CAC1S
Voltage-dependent L-type calcium channel subunit alpha-1S

1

5

High-throughput

0.501

High

310086

INP5K
Inositol polyphosphate 5-phosphatase K

1

1

High-throughput

0.501

High

310077

CC85A
Coiled-coil domain-containing protein 85A

1

1

High-throughput

0.489

High

310080

CGRE1
Cell growth regulator with EF hand domain protein 1

1

1

High-throughput

0.489

High

310093

PCDH9
Protocadherin-9

1

1

High-throughput

0.489

High

310034

NELFE
Negative elongation factor E

1

0

Small-scale

0.480

High

310052

NUCG
Endonuclease G, mitochondrial

1

0

High-throughput

0.480

High

310075

DTBP1
Dysbindin

1

0

High-throughput

0.480

High

162298

XPO1
Exportin-1

1

5

High-throughput

0.479

High

310036

APC
Adenomatous polyposis coli protein

1

17

Small-scale

0.479

High

310037

CTNB1
Catenin beta-1

1

4

Small-scale

0.479

High

310038

BRCA1
Breast cancer type 1 susceptibility protein

1

3

Small-scale

0.479

High

310047

RNF4
E3 ubiquitin-protein ligase RNF4

1

2

High-throughput

0.479

High

310055

TERF2
Telomeric repeat-binding factor 2

1

2

High-throughput

0.479

High

310059

AMOT
Angiomotin

1

16

Small-scale

0.479

High

310061

TENS2
Tensin-2

1

2

High-throughput

0.479

High

310068

AMOL1
Angiomotin-like protein 1

1

17

Small-scale

0.479

High

310079

RANB9
Ran-binding protein 9

1

2

Small-scale

0.479

High

310094

CENPJ
Centromere protein J

1

5

Small-scale

0.479

High

310108

AMOL2
Angiomotin-like protein 2

1

15

Small-scale

0.479

High

310110

RPGF2
Rap guanine nucleotide exchange factor 2

1

3

High-throughput

0.479

High

261938

PEX14
Peroxisomal membrane protein PEX14

1

0

High-throughput

0.458

High

310098

POTE1
Protection of telomeres protein 1

1

0

Small-scale

0.458

High

310112

HEY1
Hairy/enhancer-of-split related with YRPW motif protein 1

1

0

Small-scale

0.458

High

310046

3BP2
SH3 domain-binding protein 2

1

5

Small-scale

0.437

High

310076

C170L
Cep170-like protein

1

2

High-throughput

0.407

High

258887

RTN2
Reticulon-2

3

0

High-throughput

0.347

High

310057

TMM44
Transmembrane protein 44

2

0

High-throughput

0.328

High

310092

GARE1
GRB2-associated and regulator of MAPK protein 1

1

0

High-throughput

0.279

Low

310073

RUND1
RUN domain-containing protein 1

1

0

High-throughput

0.261

Low

310102

PP4RL
Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024